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Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis

  • Authors:
    • Juan Wang
    • Ning Wang
    • Fanghua Gong
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    Affiliations: Department of Ear, Nose, Throat, and Head Neck Surgery (III), Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410016, P.R. China, Department of Nursing, Hunan Provincial People's Hospital (The First-Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410016, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 198
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    Published online on: January 8, 2021
       https://doi.org/10.3892/etm.2021.9631
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Abstract

The objective of the present review and meta‑analysis was to evaluate the efficacy of bupivacaine during tonsillectomy in terms of reducing the mean operative procedure duration, post‑operative pain and the onset of post‑operative morbidities. The Preferred Reporting Items for Systematic reviews and Meta‑Analyses guidelines were followed to perform a systematic literature search using the MEDLINE, Scopus, EMBASE and CENTRAL databases. The present meta‑analysis sought to evaluate the efficacy of bupivacaine administered during tonsillectomy as compared to the administration of normal saline. The efficacy of the intervention was evaluated based on pain scores using the visual analogue scale, the duration of the operation and the occurrence of post‑operative morbidities. Out of 1,427 records, 15 articles with 729 participants (mean age, 10.2±6.7 years) were included in the study. The present systematic review supported the use of bupivacaine during tonsillectomy at a level of evidence of 1b and confirmed beneficial effects of bupivacaine intervention by demonstrating small to large effect reductions in the visual analog scale score (Hedge's g, ‑1.48), the mean duration of the operative procedure (Hedge's g, ‑1.35) and the incidence of post‑operative morbidity (Hedge's g, ‑0.23) in comparison to the placebo groups treated with normal saline. Based on these results, the administration of bupivacaine is recommended during tonsillectomies to reduce the perceived level of pain, the duration of the operation and the post‑operative morbidity.
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1 

Archer NM, Forbes PW, Dargie J, Manganella J, Licameli GR, Kenna MA and Brugnara C: Association of blood type with postsurgical mucosal bleeding in pediatric patients undergoing tonsillectomy with or without adenoidectomy. JAMA Netw Open. 3(e201804)2020.PubMed/NCBI View Article : Google Scholar

2 

Materia E, Di Domenicantonio R, Baglio G, Marchisio P, Perletti L, Lispi L, Mele A and Guasticchi G: Epidemiology of tonsillectomy and/or adenoidectomy in Italy. Pediatr Med Chir. 26:179–186. 2004.PubMed/NCBI

3 

Roushdy MM, Abdel-Ghaffar HS, Mohammed MA and Khalifa AH: Comparative study between the effect of Diclofenac and Ketorolac in post-tonsillectomy pain management. Egypt J Neck Surg Otorhinolaryngol. 6:43–53. 2020.

4 

Di Luca M, Iannella G, Montevecchi F, Magliulo G, De Vito A, Cocuzza S, Maniaci A, Meccariello G, Cammaroto G, Sgarzani R, et al: Use of the transoral robotic surgery to treat patients with recurrent lingual tonsillitis. Int J Med Robot. 16(e2106)2020.PubMed/NCBI View Article : Google Scholar

5 

Soaper AL, Richardson ZL, Chen JL and Gerber ME: Pediatric tonsillectomy: A short-term and long-term comparison of intracapsular versus extracapsular techniques. Int J Pediatr Otorhinolaryngol. 133(109970)2020.PubMed/NCBI View Article : Google Scholar

6 

Joseph M, Reardon E and Goodman M: Lingual tonsillectomy: A treatment for inflammatory lesions of the lingual tonsil. Laryngoscope. 94:179–184. 1984.PubMed/NCBI View Article : Google Scholar

7 

Krishna P and Lee D: Post-tonsillectomy bleeding: A meta-analysis. Laryngoscope. 111:1358–1361. 2001.PubMed/NCBI View Article : Google Scholar

8 

Broadman LM, Patel RI, Feldman BA, Sellman GL, Milmoe G and Camilon F: The effects of peritonsillar infiltration on the reduction of intraoperative blood loss and post-tonsillectomy pain in children. Laryngoscope. 99:578–581. 1989.PubMed/NCBI View Article : Google Scholar

9 

Teker AM, Korkut AY, Gedikli O and Kahya V: Prospective, controlled clinical trial of Ankaferd Blood Stopper in children undergoing tonsillectomy. Int J Pediatr Otorhinolaryngol. 73:1742–1745. 2009.PubMed/NCBI View Article : Google Scholar

10 

Kargi E, Hoşnuter M, Babucçu O, Altunkaya H and Altinyazar C: Effect of steroids on edema, ecchymosis, and intraoperative bleeding in rhinoplasty. Ann Plast Surg. 51:570–574. 2003.PubMed/NCBI View Article : Google Scholar

11 

Wohlgemuth PR and O'Brien GR: Postoperative edema in maxillofacial surgery; prevention and treatment with promethazine. Am J Surg. 94:537–541. 1957.PubMed/NCBI View Article : Google Scholar

12 

Xu F, Zeng W, Mao X and Fan GK: The efficacy of melilotus extract in the management of postoperative ecchymosis and edema after simultaneous rhinoplasty and blepharoplasty. Aesthetic Plast Surg. 32:599–603. 2008.PubMed/NCBI View Article : Google Scholar

13 

Davidoss NH, Eikelboom R, Friedland PL and Santa Maria PL: Wound healing after tonsillectomy - a review of the literature. J Laryngol Otol. 132:764–770. 2018.PubMed/NCBI View Article : Google Scholar

14 

Deutsch ES and Isaacson GC: Tonsils and adenoids: An update. Pediatr Rev. 16:17–21. 1995.PubMed/NCBI View Article : Google Scholar

15 

Linden BE, Gross CW, Long TE and Lazar RH: Morbidity in pediatric tonsillectomy. Laryngoscope. 100:120–124. 1990.PubMed/NCBI View Article : Google Scholar

16 

Odhagen E, Stalfors J and Sunnergren O: Morbidity after pediatric tonsillotomy versus tonsillectomy: A population-based cohort study. Laryngoscope. 129:2619–2626. 2019.PubMed/NCBI View Article : Google Scholar

17 

Nikandish R, Maghsoodi B, Khademi S, Motazedian S and Kaboodkhani R: Peritonsillar infiltration with bupivacaine and pethidine for relief of post-tonsillectomy pain: A randomised double-blind study. Anaesthesia. 63:20–25. 2008.PubMed/NCBI View Article : Google Scholar

18 

Sun J, Wu X, Meng Y and Jin L: Bupivacaine versus normal saline for relief of post-adenotonsillectomy pain in children: A meta-analysis. Int J Pediatr Otorhinolaryngol. 74:369–373. 2010.PubMed/NCBI View Article : Google Scholar

19 

Furutani K, Ikoma M, Ishii H, Baba H and Kohno T: Bupivacaine inhibits glutamatergic transmission in spinal dorsal horn neurons. Anesthesiology. 112:138–143. 2010.PubMed/NCBI View Article : Google Scholar

20 

Paganelli MA and Popescu GK: Actions of bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 35:831–842. 2015.PubMed/NCBI View Article : Google Scholar

21 

Block L, Jörneberg P, Björklund U, Westerlund A, Biber B and Hansson E: Ultralow concentrations of bupivacaine exert anti-inflammatory effects on inflammation-reactive astrocytes. Eur J Neurosci. 38:3669–3678. 2013.PubMed/NCBI View Article : Google Scholar

22 

Cassuto J, Sinclair R and Bonderovic M: Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol Scand. 50:265–282. 2006.PubMed/NCBI View Article : Google Scholar

23 

Anderson LA, Engel GM, Bruckner JD, Stoddard GJ and Peters CL: Reduced blood loss after total knee arthroplasty with local injection of bupivacaine and epinephrine. J Knee Surg. 22:130–136. 2009.PubMed/NCBI View Article : Google Scholar

24 

Metaxotos NG, Asplund O and Hayes M: The efficacy of bupivacaine with adrenaline in reducing pain and bleeding associated with breast reduction: A prospective trial. Br J Plast Surg. 52:290–293. 1999.PubMed/NCBI View Article : Google Scholar

25 

Kuthiala G and Chaudhary G: Ropivacaine: A review of its pharmacology and clinical use. Indian J Anaesth. 55:104–110. 2011.PubMed/NCBI View Article : Google Scholar

26 

Polley LS, Columb MO, Naughton NN, Wagner DS and van de Ven CJ: Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: Implications for therapeutic indexes. Anesthesiology. 90:944–950. 1999.PubMed/NCBI View Article : Google Scholar

27 

Spivey WH, McNamara RM, MacKenzie RS, Bhat S and Burdick WP: A clinical comparison of lidocaine and bupivacaine. Ann Emerg Med. 16:752–757. 1987.PubMed/NCBI View Article : Google Scholar

28 

Abdel Raheem AG and Farouk ZM: Effect of preincisional peritonsillar infiltration of bupivacaine on post-tonsillectomy pain. Egypt J Neck Surg Otorhinolaryngol. 5:40–46. 2019.

29 

Ergil J, Akkaya T, Gozaydin O, Gunsoy B, Alicura S, Aladag E, Gumus H and Akin I: Vasoconstrictive and analgesic efficacy of locally infiltrated levobupivacaine in tonsillectomy patients. Int J Pediatr Otorhinolaryngol. 76:1429–1433. 2012.PubMed/NCBI View Article : Google Scholar

30 

Junaid M, Halim MS, Onali MA, Qadeer S, Khan HU and Ali NS: Intraoperative use of analgesics in tonsillar fossa and postoperative evaluation with visual analogue scale scores-A prospective, randomized, placebo-controlled, double-blind clinical trial. Int Arch Otorhinolaryngol. 24:e62–e67. 2020.PubMed/NCBI View Article : Google Scholar

31 

Ozkiriş M, Kapusuz Z and Saydam L: Comparison of ropivacaine, bupivacaine and lidocaine in the management of post-tonsillectomy pain. Int J Pediatr Otorhinolaryngol. 76:1831–1834. 2012.PubMed/NCBI View Article : Google Scholar

32 

Haksever M, Özmen S, Akduman D and Solmaz F: Topical bupivacaine compared to bupivacaine infiltration for post-tonsillectomy pain relief in children: A prospective randomized controlled clinical study. Eur Arch Otorhinolaryngol. 271:2555–2559. 2014.PubMed/NCBI View Article : Google Scholar

33 

Özmen OA and Özmen S: Topical bupivacaine compared to lidocaine with epinephrine for post-tonsillectomy pain relief in children: A randomized controlled study. Int J Pediatr Otorhinolaryngol. 75:77–80. 2011.PubMed/NCBI View Article : Google Scholar

34 

Tuhanioglu B and Erkan SO: Tonsillectomy pain control with IV dexamethasone, infiltrated dexamethasone and infiltrated bupivacaine; a randomised, double-blind, placebo controlled, prospective clinical trial. J Pak Med Assoc. 68:1002–1008. 2018.PubMed/NCBI

35 

Moher D, Liberati A, Tetzlaff J and Altman DG: PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med. 6(e1000097)2009.PubMed/NCBI View Article : Google Scholar

36 

Jørgensen L, Paludan-Müller AS, Laursen DR, Savović J, Boutron I, Sterne JA, Higgins JP and Hróbjartsson A: Evaluation of the Cochrane tool for assessing risk of bias in randomized clinical trials: Overview of published comments and analysis of user practice in Cochrane and non-Cochrane reviews. Syst Rev. 5(80)2016.PubMed/NCBI View Article : Google Scholar

37 

Viswanathan M, Ansari MT, Berkman ND, Chang S, Hartling L, McPheeters M, Santaguida PL, Shamliyan T, Singh K, Tsertsvadze A, et al: Assessing the risk of bias of individual studies in systematic reviews of health care interventions. In: Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality (US), Rockville, MD, 2008.

38 

Burns PB, Rohrich RJ and Chung KC: The levels of evidence and their role in evidence-based medicine. Plast Reconstr Surg. 128:305–310. 2011.PubMed/NCBI View Article : Google Scholar

39 

Bax L, Yu LM, Ikeda N and Moons KG: A systematic comparison of software dedicated to meta-analysis of causal studies. BMC Med Res Methodol. 7(40)2007.PubMed/NCBI View Article : Google Scholar

40 

Higgins JP, Thompson SG and Spiegelhalter DJ: A re-evaluation of random-effects meta-analysis. J R Stat Soc Ser A Stat Soc. 172:137–159. 2009.PubMed/NCBI View Article : Google Scholar

41 

Rosenthal R: Parametric measures of effect size. In: The Handbook of Research Synthesis. Russell Sage Foundation, New York, NY, pp231-244, 1994.

42 

Higgins JP and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002.PubMed/NCBI View Article : Google Scholar

43 

Petitti DB: Approaches to heterogeneity in meta-analysis. Stat Med. 20:3625–3633. 2001.PubMed/NCBI View Article : Google Scholar

44 

Duval S and Tweedie R: Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 56:455–463. 2000.PubMed/NCBI View Article : Google Scholar

45 

Karaaslan K, Yilmaz F, Gulcu N, Sarpkaya A, Colak C and Kocoglu H: The effects of levobupivacaine versus levobupivacaine plus magnesium infiltration on postoperative analgesia and laryngospasm in pediatric tonsillectomy patients. Int J Pediatr Otorhinolaryngol. 72:675–681. 2008.PubMed/NCBI View Article : Google Scholar

46 

Akoglu E, Akkurt BC, Inanoglu K, Okuyucu S and Dagli S: Ropivacaine compared to bupivacaine for post-tonsillectomy pain relief in children: A randomized controlled study. Int J Pediatr Otorhinolaryngol. 70:1169–1173. 2006.PubMed/NCBI View Article : Google Scholar

47 

Jebeles JA, Reilly JS, Gutierrez JF, Bradley EL Jr and Kissin I: The effect of pre-incisional infiltration of tonsils with bupivacaine on the pain following tonsillectomy under general anesthesia. Pain. 47:305–308. 1991.PubMed/NCBI View Article : Google Scholar

48 

Johansen M, Harbo G and Illum P: Preincisional infiltration with bupivacaine in tonsillectomy. Arch Otolaryngol Head Neck Surg. 122:261–263. 1996.PubMed/NCBI View Article : Google Scholar

49 

Kaygusuz I and Susaman N: The effects of dexamethasone, bupivacaine and topical lidocaine spray on pain after tonsillectomy. Int J Pediatr Otorhinolaryngol. 67:737–742. 2003.PubMed/NCBI View Article : Google Scholar

50 

Stuart JC, MacGregor FB, Cairns CS and Chandrachud HR: Peritonsillar infiltration with bupivacaine for paediatric tonsillectomy. Anaesth Intensive Care. 22:679–682. 1994.PubMed/NCBI View Article : Google Scholar

51 

Unal Y, Pampal K, Korkmaz S, Arslan M, Zengin A and Kurtipek O: Comparison of bupivacaine and ropivacaine on postoperative pain after tonsillectomy in paediatric patients. Int J Pediatr Otorhinolaryngol. 71:83–87. 2007.PubMed/NCBI View Article : Google Scholar

52 

Sedgwick P: Meta-analyses: How to read a funnel plot. BMJ. 346(f1342)2013.

53 

Terrin N, Schmid CH and Lau J: In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias. J Clin Epidemiol. 58:894–901. 2005.PubMed/NCBI View Article : Google Scholar

54 

Bangera A: Anaesthesia for adenotonsillectomy: An update. Indian J Anaesth. 61:103–109. 2017.PubMed/NCBI View Article : Google Scholar

55 

Verma R and Verma RR and Verma RR: Tonsillectomy-comparative study of various techniques and changing trend. Indian J Otolaryngol Head Neck Surg. 69:549–558. 2017.PubMed/NCBI View Article : Google Scholar

56 

Babst CR and Gilling BN: Bupivacaine: A review. Anesth Prog. 25:87–91. 1978.PubMed/NCBI View Article : Google Scholar

57 

Iida H, Watanabe Y, Dohi S and Ishiyama T: Direct effects of ropivacaine and bupivacaine on spinal pial vessels in canine. Assessment with closed spinal window technique. Anesthesiology. 87:75–81. 1997.PubMed/NCBI View Article : Google Scholar

58 

Newton DJ, McLeod GA, Khan F and Belch JJ: Vasoactive characteristics of bupivacaine and levobupivacaine with and without adjuvant epinephrine in peripheral human skin. Br J Anaesth. 94:662–667. 2005.PubMed/NCBI View Article : Google Scholar

59 

Prasad KC and Prasad SC: Assessment of operative blood loss and the factors affecting it in tonsillectomy and adenotonsillectomy. Indian J Otolaryngol Head Neck Surg. 63:343–348. 2011.PubMed/NCBI View Article : Google Scholar

60 

Yu CN, Chow TK, Kwan AS, Wong SL and Fung SC: Intra-operative blood loss and operating time in orthognathic surgery using induced hypotensive general anaesthesia: Prospective study. Hong Kong Med J. 6:307–311. 2000.PubMed/NCBI

61 

Nosulia EV: Peculiarities of blood supply of palatal tonsils and the potential risk of hemorrhage during tonsillectomy: The literature review and case report. Vestn Otorinolaringol. 1:75–78. 2014.PubMed/NCBI(In Russian).

62 

Liu JH, Anderson KE, Willging JP, Myer CM III, Shott SR, Bratcher GO and Cotton RT: Posttonsillectomy hemorrhage: What is it and what should be recorded? Arch Otolaryngol Head Neck Surg. 127:1271–1275. 2001.PubMed/NCBI View Article : Google Scholar

63 

Mutz I and Simon H: Hemorrhagic complications after tonsillectomy and adenoidectomy. Experiences with 7,743 operations in 14 years. Wien Klin Wochenschr. 105:520–522. 1993.PubMed/NCBI(In German).

64 

PLoS Medicine Editors. Best practice in systematic reviews: The importance of protocols and registration. PLoS Med. 8(e1001009)2011.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Wang J, Wang N and Gong F: Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis. Exp Ther Med 21: 198, 2021.
APA
Wang, J., Wang, N., & Gong, F. (2021). Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 21, 198. https://doi.org/10.3892/etm.2021.9631
MLA
Wang, J., Wang, N., Gong, F."Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 21.3 (2021): 198.
Chicago
Wang, J., Wang, N., Gong, F."Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 21, no. 3 (2021): 198. https://doi.org/10.3892/etm.2021.9631
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Spandidos Publications style
Wang J, Wang N and Gong F: Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis. Exp Ther Med 21: 198, 2021.
APA
Wang, J., Wang, N., & Gong, F. (2021). Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 21, 198. https://doi.org/10.3892/etm.2021.9631
MLA
Wang, J., Wang, N., Gong, F."Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 21.3 (2021): 198.
Chicago
Wang, J., Wang, N., Gong, F."Efficacy of bupivacaine infiltration for controlling post‑tonsillectomy pain, duration of surgery and post‑operative morbidities: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 21, no. 3 (2021): 198. https://doi.org/10.3892/etm.2021.9631
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