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Article

NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer

  • Authors:
    • Zhe Fan
    • Jiyong Pan
    • Hai Wang
    • Yewei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of General Surgery, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, Liaoning 116033, P.R. China, Department of Pathology, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, Liaoning 116033, P.R. China
  • Article Number: 208
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    Published online on: January 14, 2021
       https://doi.org/10.3892/etm.2021.9640
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Abstract

Gastric cancer (GC) is a common cancer worldwide and its precise mechanism is largely unknown. The aim of the present study was to evaluate the expression levels of NOD‑like receptor X1 (NLRX1), tumor necrosis factor receptor‑associated factor 6 (TRAF6) and NF‑κB in GC and normal gastric tissue samples to determine the association with the clinicopathological features of GC. GC and adjacent normal gastric tissues from 60 patients with GC were analyzed using immunohistochemistry and western blotting analysis. In addition, the association between NLRX1, TRAF6 and NF‑κB expression levels were investigated by Spearman's correlation analysis. The results revealed that NLRX1 protein expression levels were downregulated in the GC tissues compared with the normal gastric tissues (P<0.05). Conversely, TRAF6 and NF‑κB protein expression levels were upregulated in the GC tissues compared with the normal gastric tissues (P<0.05). A significant difference was identified between GC patients with high and low expression levels of each protein in the tumor size, vascular invasion, neural invasion, lymph node metastasis, differentiation, gross stage and clinical stage. In addition, a negative correlation was observed between NLRX1 and TRAF6, and NLRX1 and NF‑κB expression levels, while a positive correlation was observed between TRAF6 and NF‑κB expression levels. In conclusion, NLRX1 expression levels were discovered to be downregulated in GC tissues. The expression levels of NLRX1, TRAF6 and NF‑κB were also significantly associated with the clinicopathological characteristics of GC, and the aforementioned results indicated that NLRX1 may be a biomarker in assessing GC.
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Copy and paste a formatted citation
Spandidos Publications style
Fan Z, Pan J, Wang H and Zhang Y: NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer. Exp Ther Med 21: 208, 2021.
APA
Fan, Z., Pan, J., Wang, H., & Zhang, Y. (2021). NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer. Experimental and Therapeutic Medicine, 21, 208. https://doi.org/10.3892/etm.2021.9640
MLA
Fan, Z., Pan, J., Wang, H., Zhang, Y."NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer". Experimental and Therapeutic Medicine 21.3 (2021): 208.
Chicago
Fan, Z., Pan, J., Wang, H., Zhang, Y."NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer". Experimental and Therapeutic Medicine 21, no. 3 (2021): 208. https://doi.org/10.3892/etm.2021.9640
Copy and paste a formatted citation
x
Spandidos Publications style
Fan Z, Pan J, Wang H and Zhang Y: NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer. Exp Ther Med 21: 208, 2021.
APA
Fan, Z., Pan, J., Wang, H., & Zhang, Y. (2021). NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer. Experimental and Therapeutic Medicine, 21, 208. https://doi.org/10.3892/etm.2021.9640
MLA
Fan, Z., Pan, J., Wang, H., Zhang, Y."NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer". Experimental and Therapeutic Medicine 21.3 (2021): 208.
Chicago
Fan, Z., Pan, J., Wang, H., Zhang, Y."NOD‑like receptor X1, tumor necrosis factor receptor‑associated factor 6 and NF‑κB are associated with clinicopathological characteristics in gastric cancer". Experimental and Therapeutic Medicine 21, no. 3 (2021): 208. https://doi.org/10.3892/etm.2021.9640
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