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Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia

  • Authors:
    • Mingqian He
    • Mei Deng
    • Jingya Wang
    • Pengxia Fan
    • Yue Wang
    • Xinrui Zhao
    • Yizhi He
    • Bingyin Shi
    • Jing Sui
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Shaanxi 710061, P.R. China, Department of Endocrinology, Shanxian Central Hospital, Shanxian, Shandong 274300, P.R. China, Department of Immunology and Rheumatology, The Second Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Shaanxi 710004, P.R. China, Department of Endocrinology, Xi'an No. 3 Hospital, Xi'an, Shaanxi 710018, P.R. China, Department of Endocrinology and International Medical Center, The First Affiliated Hospital of Xi'an JiaoTong University, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 217
    |
    Published online on: January 15, 2021
       https://doi.org/10.3892/etm.2021.9649
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Abstract

The safety and efficacy of dipeptidyl peptidase‑4 inhibitors in patients newly diagnosed type 2 diabetes mellitus (T2DM) with severe hyperglycaemia have remained to be sufficiently demonstrated. The aim of the present study was to determine whether sitagliptin combined with metformin as an initial treatment had non‑inferior outcomes with regards to glycaemic remission and β‑cell function recovery to those of standard insulin therapy in this patient group. A prospective observational study was performed comparing the effects of sitagliptin combined with metformin and insulin therapy in a real‑world clinical setting. A total of 168 participants were enrolled and received sitagliptin combined with metformin (Sig) or insulin (Ins) for almost 4 weeks. In addition, each group was further stratified into three subgroups, according to glycosylated haemoglobin (HbA1c) levels (<10, 10‑12 and >12%). The primary outcomes were β‑cell function and changes in fasting plasma glucose (FPG) and HbA1c at the 3‑month follow‑up. Both insulin and sitagliptin combined with metformin reduced hyperglycaemia and achieved similar glycaemic outcomes, and no significant differences in FPG and HbA1c levels were obtained. No significant changes were observed in β‑cell function concomitant with the glucose‑lowering effects of the treatments. Of note, participants in the Ins group exhibited weight gain, whereas those in the Sig group had weight loss, with significant differences becoming evident after 1 month, particularly in the HbA1c <10% subgroup. As compared with insulin injection, early treatment with sitagliptin combined with metformin in newly diagnosed patients with T2DM and severe hyperglycaemia produced non‑inferior outcomes with regards to glycaemic remission. Therefore, combination of sitagliptin and metformin may be a viable initial treatment option for patients who prefer an alternative to insulin injection. This study was registered with ClinicalTrials.gov under no. NCT03180281.
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Copy and paste a formatted citation
Spandidos Publications style
He M, Deng M, Wang J, Fan P, Wang Y, Zhao X, He Y, Shi B and Sui J: Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia. Exp Ther Med 21: 217, 2021.
APA
He, M., Deng, M., Wang, J., Fan, P., Wang, Y., Zhao, X. ... Sui, J. (2021). Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia. Experimental and Therapeutic Medicine, 21, 217. https://doi.org/10.3892/etm.2021.9649
MLA
He, M., Deng, M., Wang, J., Fan, P., Wang, Y., Zhao, X., He, Y., Shi, B., Sui, J."Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia". Experimental and Therapeutic Medicine 21.3 (2021): 217.
Chicago
He, M., Deng, M., Wang, J., Fan, P., Wang, Y., Zhao, X., He, Y., Shi, B., Sui, J."Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia". Experimental and Therapeutic Medicine 21, no. 3 (2021): 217. https://doi.org/10.3892/etm.2021.9649
Copy and paste a formatted citation
x
Spandidos Publications style
He M, Deng M, Wang J, Fan P, Wang Y, Zhao X, He Y, Shi B and Sui J: Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia. Exp Ther Med 21: 217, 2021.
APA
He, M., Deng, M., Wang, J., Fan, P., Wang, Y., Zhao, X. ... Sui, J. (2021). Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia. Experimental and Therapeutic Medicine, 21, 217. https://doi.org/10.3892/etm.2021.9649
MLA
He, M., Deng, M., Wang, J., Fan, P., Wang, Y., Zhao, X., He, Y., Shi, B., Sui, J."Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia". Experimental and Therapeutic Medicine 21.3 (2021): 217.
Chicago
He, M., Deng, M., Wang, J., Fan, P., Wang, Y., Zhao, X., He, Y., Shi, B., Sui, J."Efficacy and tolerability of sitagliptin and metformin compared with insulin as an initial therapy for newly diagnosed diabetic patients with severe hyperglycaemia". Experimental and Therapeutic Medicine 21, no. 3 (2021): 217. https://doi.org/10.3892/etm.2021.9649
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