Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2021 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2021 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1

  • Authors:
    • Lijun Liu
    • Jun Zhang
    • Yujuan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Weifang Maternal and Child Health Hospital, Weifang, Shandong 261011, P.R. China, Department of Pharmacy, Weifang Maternal and Child Health Hospital, Weifang, Shandong 261011, P.R. China, Department of Central Supply Room, Weifang Maternal and Child Health Hospital, Weifang, Shandong 261011, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 230
    |
    Published online on: January 20, 2021
       https://doi.org/10.3892/etm.2021.9661
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gestational diabetes mellitus (GDM) leads to poor pregnancy outcomes, and microRNAs (miRNAs/miRs) have been suggested to be associated with GDM, but the pathological mechanisms remain unclear. The present study aimed to investigate the diagnostic value of miR‑1323 in GDM patients and its effects on trophoblast cell viability. Additionally, the present study investigated the correlation between miR‑1323 and TP53INP1 to understand the pathological mechanism of GDM progression. Reverse transcription‑quantitative polymerase chain reaction was used to detect the miR‑1323 expression and TP53INP1 mRNA expression. The diagnostic value of serum miR‑1323 was evaluated by receiver operating characteristic analysis. HTR‑8/SVneo and BeWo cells were treated with high glucose (HG) to construct cell models of GDM, and trophoblast cell viability was assessed using an MTT assay. The protein expression of TP53INP1 was detected by western blot analysis. The correlation between miR‑1323 and TP53INP1 was investigated by luciferase reporter assay. The miR‑1323 expression was increased in patients with GDM, which had relatively high diagnostic accuracy for GDM screening and was positively correlated with fasting blood glucose in patients GDM. HG upregulated the miR‑1323 expression and inhibited trophoblast cell viability. Overexpression of miR‑1323 significantly inhibited the viability of HG‑induced trophoblast cells. TP53INP1, a target gene of miR‑1323, was negatively correlated with miR‑1323. TP53INP1 overexpression reversed the inhibitory effect of miR‑1323 overexpression on the viability of HG‑treated trophoblast cells. Increased levels of serum miR‑1323 may be a diagnostic biomarker for GDM. Additionally, miR‑1323 may inhibit trophoblast cell viability by inhibiting TP53INP1, suggesting that it may be a potential therapeutic target for GDM.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Chiefari E, Arcidiacono B, Foti D and Brunetti A: Gestational diabetes mellitus: An updated overview. J Endocrinol Invest. 40:899–909. 2017.PubMed/NCBI View Article : Google Scholar

2 

Lavery JA, Friedman AM, Keyes KM, Wright JD and Ananth CV: Gestational diabetes in the United States: Temporal changes in prevalence rates between 1979 and 2010. BJOG. 124:804–813. 2017.PubMed/NCBI View Article : Google Scholar

3 

Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 190: Gestational diabetes mellitus. Obstet Gynecol. 131:e49–e64. 2018.PubMed/NCBI View Article : Google Scholar

4 

Yung HW, Alnaes-Katjavivi P, Jones CJ, El-Bacha T, Golic M, Staff AC and Burton GJ: Placental endoplasmic reticulum stress in gestational diabetes: The potential for therapeutic intervention with chemical chaperones and antioxidants. Diabetologia. 59:2240–2250. 2016.PubMed/NCBI View Article : Google Scholar

5 

Edu A, Teodorescu C, Dobjanschi CG, Socol ZZ, Teodorescu V, Matei A, Albu DF and Radulian G: Placenta changes in pregnancy with gestational diabetes. Rom J Morphol Embryol. 57:507–512. 2016.PubMed/NCBI View Article : Google Scholar

6 

Wang Y, Ji L, Peng Z, Lai R, Zhang X, Xu Y, Chen Z, Liu R, Zhong Y, Hu H and Wang L: Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment. Mol Cell Endocrinol. 502(110674)2020.PubMed/NCBI View Article : Google Scholar

7 

Chang SC and Vivian Yang WC: Hyperglycemia induces altered expressions of angiogenesis associated molecules in the trophoblast. Evid Based Complement Alternat Med. 2013(457971)2013.PubMed/NCBI View Article : Google Scholar

8 

Zong S, Li C, Luo C, Zhao X, Liu C, Wang K, Jia W, Bai M, Yin M, Bao S, et al: Dysregulated expression of IDO may cause unexplained recurrent spontaneous abortion through suppression of trophoblast cell proliferation and migration. Sci Rep. 6(19916)2016.PubMed/NCBI View Article : Google Scholar

9 

Tian FJ, Qin CM, Li XC, Wu F, Liu XR, Xu WM and Lin Y: Decreased stathmin-1 expression inhibits trophoblast proliferation and invasion and is associated with recurrent miscarriage. Am J Pathol. 185:2709–2721. 2015.PubMed/NCBI View Article : Google Scholar

10 

Gao Y, She R, Wang Q, Li Y and Zhang H: Up-regulation of miR-299 suppressed the invasion and migration of HTR-8/SVneo trophoblast cells partly via targeting HDAC2 in pre-eclampsia. Biomed Pharmacother. 97:1222–1228. 2018.PubMed/NCBI View Article : Google Scholar

11 

Dias S, Pheiffer C, Abrahams Y, Rheeder P and Adam S: Molecular biomarkers for gestational diabetes mellitus. Int J Mol Sci. 19(2926)2018.PubMed/NCBI View Article : Google Scholar

12 

Tryggestad JB, Vishwanath A, Jiang S, Mallappa A, Teague AM, Takahashi Y, Thompson DM and Chernausek SD: Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. Clin Sci (Lond). 130:1955–1967. 2016.PubMed/NCBI View Article : Google Scholar

13 

Pheiffer C, Dias S, Rheeder P and Adam S: Decreased expression of circulating miR-20a-5p in South African women with gestational diabetes mellitus. Mol Diagn Ther. 22:345–352. 2018.PubMed/NCBI View Article : Google Scholar

14 

Yoffe L, Polsky A, Gilam A, Raff C, Mecacci F, Ognibene A, Crispi F, Gratacós E, Kanety H, Mazaki-Tovi S, et al: Early diagnosis of gestational diabetes mellitus using circulating microRNAs. Eur J Endocrinol. 181:565–577. 2019.PubMed/NCBI View Article : Google Scholar

15 

Gillet V, Ouellet A, Stepanov Y, Rodosthenous RS, Croft EK, Brennan K, Abdelouahab N, Baccarelli A and Takser L: miRNA profiles in extracellular vesicles from serum early in pregnancies complicated by gestational diabetes mellitus. J Clin Endocrinol Metab. 104:5157–5169. 2019.PubMed/NCBI View Article : Google Scholar

16 

Na Q, Wang D and Song W: Underexpression of 4 placenta-associated microRNAs in complete hydatidiform moles. Int J Gynecol Cancer. 22:1075–1080. 2012.PubMed/NCBI View Article : Google Scholar

17 

Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, et al: Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med. 7:802–818. 2015.PubMed/NCBI View Article : Google Scholar

18 

Zhang F, Yang C, Xing Z, Liu P, Zhang B, Ma X, Huang L and Zhuang L: LncRNA GAS5-mediated miR-1323 promotes tumor progression by targeting TP53INP1 in hepatocellular carcinoma. Onco Targets Ther. 12:4013–4023. 2019.PubMed/NCBI View Article : Google Scholar

19 

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabet Care. 35 (Suppl 1):S64–S71. 2012.

20 

Tiongco RE, Bituin A, Arceo E, Rivera N and Singian E: Salivary glucose as a non-invasive biomarker of type 2 diabetes mellitus. J Clin Exp Dent. 10:e902–e907. 2018.PubMed/NCBI View Article : Google Scholar

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

22 

Chen X, Gong Y, Zhang DH, You ZH and Li ZW: DRMDA: Deep representations-based miRNA-disease association prediction. J Cell Mol Med. 22:472–485. 2018.PubMed/NCBI View Article : Google Scholar

23 

Fang M, Li Y, Wu Y, Ning Z, Wang X and Li X: miR-185 silencing promotes the progression of atherosclerosis via targeting stromal interaction molecule 1. Cell Cycle. 18:682–695. 2019.PubMed/NCBI View Article : Google Scholar

24 

Liu Y, Bi X, Xiong J, Han W, Xiao T, Xu X, Yang K, Liu C, Jiang W, He T, et al: MicroRNA-34a promotes renal fibrosis by downregulation of klotho in tubular epithelial cells. Mol Ther. 27:1051–1065. 2019.PubMed/NCBI View Article : Google Scholar

25 

Zhou X, Xiang C and Zheng X: miR-132 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability. Diagn Pathol. 14(119)2019.PubMed/NCBI View Article : Google Scholar

26 

Qi S and Wang X: Decreased expression of miR-185 in serum and placenta of patients with gestational diabetes mellitus. Clin Lab. 65:2019.PubMed/NCBI View Article : Google Scholar

27 

Bertoli G, Cava C and Castiglioni I: The potential of miRNAs for diagnosis, treatment and monitoring of breast cancer. Scand J Clin Lab Invest Suppl. 245 (Suppl 1):S34–S39. 2016.PubMed/NCBI View Article : Google Scholar

28 

Yang M, Zhao L and Sun M: Diagnostic value of miR-103 in patients with sepsis and noninfectious SIRS and its regulatory role in LPS-induced inflammatory response by targeting TLR4. Int J Genomics. 2020(2198308)2020.PubMed/NCBI View Article : Google Scholar

29 

Liu W, Zhao X, Zhang YJ, Fang GW and Xue Y: MicroRNA-375 as a potential serum biomarker for the diagnosis, prognosis, and chemosensitivity prediction of osteosarcoma. J Int Med Res. 46:975–983. 2018.PubMed/NCBI View Article : Google Scholar

30 

Zhao H, Zheng C, Wang Y, Hou K, Yang X, Cheng Y, Che X, Xie S, Wang S, Zhang T, et al: miR-1323 promotes cell migration in lung adenocarcinoma by targeting Cbl-b and is an early prognostic biomarker. Front Oncol. 10(181)2020.PubMed/NCBI View Article : Google Scholar

31 

Xu Y and Liu M: MicroRNA-1323 downregulation promotes migration and invasion of breast cancer cells by targeting tumor protein D52. J Biochem. 168:83–91. 2020.PubMed/NCBI View Article : Google Scholar

32 

Peng HY, Li MQ and Li HP: High glucose suppresses the viability and proliferation of HTR8/SVneo cells through regulation of the miR137/PRKAA1/IL6 axis. Int J Mol Med. 42:799–810. 2018.PubMed/NCBI View Article : Google Scholar

33 

Ji L and Li X: Long noncoding RNA MEG3 is a tumor suppressor in choriocarcinoma by upregulation of microRNA-211. J Cell Physiol. 234:22911–22920. 2019.PubMed/NCBI View Article : Google Scholar

34 

Peng HY, Li MQ and Li HP: miR-137 restricts the viability and migration of HTR-8/SVneo cells by downregulating FNDC5 in gestational diabetes mellitus. Curr Mol Med. 19:494–505. 2019.PubMed/NCBI View Article : Google Scholar

35 

Nishimoto M, Nishikawa S, Kondo N, Wanifuchi-Endo Y, Hato Y, Hisada T, Dong Y, Okuda K, Sugiura H, Kato H, et al: Prognostic impact of TP53INP1 gene expression in estrogen receptor α-positive breast cancer patients. Jpn J Clin Oncol. 49:567–575. 2019.PubMed/NCBI View Article : Google Scholar

36 

Du J, Yang ST, Liu J, Zhang KX and Leng JY: Silence of LncRNA GAS5 protects cardiomyocytes H9c2 against hypoxic injury via sponging miR-142-5p. Mol Cells. 42:397–405. 2019.PubMed/NCBI View Article : Google Scholar

37 

Li N, Cui T, Guo W, Wang D and Mao L: miR-155-5p accelerates the metastasis of cervical cancer cell via targeting TP53INP1. Onco Targets Ther. 12:3181–3196. 2019.PubMed/NCBI View Article : Google Scholar

38 

Ye W, Liang F, Ying C, Zhang M, Feng D and Jiang X: Downregulation of microRNA-3934-5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1. Exp Ther Med. 18:3729–3736. 2019.PubMed/NCBI View Article : Google Scholar

39 

Dou J, Tu D, Zhao H and Zhang X: LncRNA PCAT18/miR-301a/TP53INP1 axis is involved in gastric cancer cell viability, migration, and invasion. J Biochem. 168:547–555. 2020.PubMed/NCBI View Article : Google Scholar

40 

Abou-Kheir W, Barrak J, Hadadeh O and Daoud G: HTR-8/SVneo cell line contains a mixed population of cells. Placenta. 50:1–7. 2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu L, Zhang J and Liu Y: MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1. Exp Ther Med 21: 230, 2021.
APA
Liu, L., Zhang, J., & Liu, Y. (2021). MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1. Experimental and Therapeutic Medicine, 21, 230. https://doi.org/10.3892/etm.2021.9661
MLA
Liu, L., Zhang, J., Liu, Y."MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1". Experimental and Therapeutic Medicine 21.3 (2021): 230.
Chicago
Liu, L., Zhang, J., Liu, Y."MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1". Experimental and Therapeutic Medicine 21, no. 3 (2021): 230. https://doi.org/10.3892/etm.2021.9661
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Zhang J and Liu Y: MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1. Exp Ther Med 21: 230, 2021.
APA
Liu, L., Zhang, J., & Liu, Y. (2021). MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1. Experimental and Therapeutic Medicine, 21, 230. https://doi.org/10.3892/etm.2021.9661
MLA
Liu, L., Zhang, J., Liu, Y."MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1". Experimental and Therapeutic Medicine 21.3 (2021): 230.
Chicago
Liu, L., Zhang, J., Liu, Y."MicroRNA‑1323 serves as a biomarker in gestational diabetes mellitus and aggravates high glucose‑induced inhibition of trophoblast cell viability by suppressing TP53INP1". Experimental and Therapeutic Medicine 21, no. 3 (2021): 230. https://doi.org/10.3892/etm.2021.9661
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team