Open Access

Challenges of phototherapy for neonatal hyperbilirubinemia (Review)

  • Authors:
    • Juan Wang
    • Genxin Guo
    • Aimin Li
    • Wen-Qi Cai
    • Xianwang Wang
  • View Affiliations

  • Published online on: January 20, 2021     https://doi.org/10.3892/etm.2021.9662
  • Article Number: 231
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Phototherapy is universally recognized as the first option for treating neonatal jaundice due to its unparalleled efficiency and safety in reducing the high serum free bilirubin levels and limiting its neurotoxic effects. However, several studies have suggested that phototherapy may elicit a series of short‑ and long‑term adverse reactions associated with pediatric diseases, including hemolysis, allergic diseases, DNA damage or even cancer. The aim of the present review was to summarize the etiology, mechanism, associated risks and therapeutic strategies for reducing high neonatal serum bilirubin levels. In order to shed light on the negative effects of phototherapy and to encourage implementation of a reasonable and standardized phototherapy scheme in the clinic, the present review sought to highlight the current understanding of the adverse reactions of phototherapy, as it is necessary to further study the mechanism underlying the development of the adverse effects of phototherapy in infants in order to explore novel therapeutic alternatives.
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March-2021
Volume 21 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Guo G, Li A, Cai W and Wang X: Challenges of phototherapy for neonatal hyperbilirubinemia (Review). Exp Ther Med 21: 231, 2021
APA
Wang, J., Guo, G., Li, A., Cai, W., & Wang, X. (2021). Challenges of phototherapy for neonatal hyperbilirubinemia (Review). Experimental and Therapeutic Medicine, 21, 231. https://doi.org/10.3892/etm.2021.9662
MLA
Wang, J., Guo, G., Li, A., Cai, W., Wang, X."Challenges of phototherapy for neonatal hyperbilirubinemia (Review)". Experimental and Therapeutic Medicine 21.3 (2021): 231.
Chicago
Wang, J., Guo, G., Li, A., Cai, W., Wang, X."Challenges of phototherapy for neonatal hyperbilirubinemia (Review)". Experimental and Therapeutic Medicine 21, no. 3 (2021): 231. https://doi.org/10.3892/etm.2021.9662