MicroRNA‑598 inhibits the growth of triple negative breast cancer cells by targeting JAG1
- Guohui Han
- Xiangdong Bai
- Hongchuan Jiang
- Qiang He
Affiliations: Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi 030013, P.R. China, Department of Breast Surgery, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, Beijing 100020, P.R. China, Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, The Affiliated Hospital of Capital Medical University, Beijing 100020, P.R. China
- Published online on: January 21, 2021 https://doi.org/10.3892/etm.2021.9666
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Triple‑negative breast cancer (TNBC) has an aggressive phenotype and a poor outcome. The discovery that dysregulated microRNAs (miRNAs) play an important role in tumor progression has led to the suggestion that miRNAs (miRs) could be a potential target for the treatment of TNBC. In the present study, it was demonstrated that miR‑598 expression was significantly decreased in TNBC tissues and was related to the degree of lymph node metastasis of patients with TNBC. Ectopic expression of miR‑598 suppressed viability and colony formation, as well as increased the apoptosis of TNBC cells. To further understand the functional mechanism of action underlying miR‑598 in TNBC, targets of miR‑598 were predicted with the miRDB bioinformatics tool. Jagged 1 (JAG1) was identified as a direct target of miR‑598, possessing a binding site for miR‑598 in its 3'‑untranslated region. Overexpression of miR‑598 inhibited the expression of JAG1 in TNBC cells. In addition, JAG1 was highly expressed in TNBC tissues and its expression was negatively correlated with the expression of miR‑598. Overexpression of JAG1 significantly attenuated the inhibitory effects of miR‑598 on the proliferation and colony formation of TNBC cells. Collectively, these results provided novel insights into the functional mechanism of action for the miR‑598/JAG1 pathway in the development of TNBC.