Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2021 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2021 Volume 21 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression

  • Authors:
    • Chenhao Tong
    • Jiandong Li
    • Weiguo Lin
    • Wenda Cen
    • Weiguang Zhang
    • Zhiyang Zhu
    • Baochun Lu
    • Jianhua Yu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China, Department of Hepatobiliary Surgery, The First Affiliated Hospital, Shaoxing University School of Medicine, Shaoxing, Zhejiang 312000, P.R. China, Department of Molecular Medicine and Clinical Laboratory, Shaoxing Second Hospital, Shaoxing, Zhejiang 312000, P.R. China
    Copyright: © Tong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 241
    |
    Published online on: January 21, 2021
       https://doi.org/10.3892/etm.2021.9672
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Severe cholestatic liver injury diseases, such as obstructive jaundice and the subsequent acute obstructive cholangitis, are induced by biliary tract occlusion. Heat shock protein 90 (HSP90) inhibitors have been demonstrated to be protective for various organs. The potential of HSP90 inhibitors in the treatment of cholestatic liver injury, however, remains unclear. In the present study, rat models of bile duct ligation (BDL) were established, the HSP90 inhibitor 17‑dimethylamino‑ethylamino‑17‑demethoxygeldanamycin (17‑DMAG) was administered, and its ability to ameliorate the cholestasis‑induced liver injuries was evaluated. In the BDL rat models and clinical samples, increased HSP90 expression was observed to be associated with cholestatic liver injury. Furthermore, 17‑DMAG alleviated cholestasis‑induced liver injury in the rat models, as revealed by the assessment of pathological changes and liver function. In addition, 17‑DMAG protected hepatocytes against cholestatic injury in vitro. Further assays indicated that 17‑DMAG administration prevented cholestasis‑induced liver injury in the rats by decreasing the expression of interleukin (IL)‑1β and IL‑18. Moreover, 17‑DMAG also decreased the cholestasis‑induced upregulation of IL‑1β and IL‑18 in liver sinusoidal endothelial cells in vitro. In conclusion, the HSP90 inhibitor 17‑DMAG is able to prevent liver injury in rats with biliary obstruction, and this phenomenon is associated with the reduction of IL‑1β and IL‑18 expression.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Addley J and Mitchell RM: Advances in the investigation of obstructive jaundice. Curr Gastroenterol Rep. 14:511–519. 2012.PubMed/NCBI View Article : Google Scholar

2 

Mosler P: Diagnosis and management of acute cholangitis. Curr Gastroenterol Rep. 13:166–172. 2011.PubMed/NCBI View Article : Google Scholar

3 

Lazaridis KN and LaRusso NF: The cholangiopathies. Mayo Clin Proc. 90:791–800. 2015.PubMed/NCBI View Article : Google Scholar

4 

O'Neill S, Ross JA, Wigmore SJ and Harrison EM: The role of heat shock protein 90 in modulating ischemia-reperfusion injury in the kidney. Expert Opin Investig Drugs. 21:1535–1548. 2012.PubMed/NCBI View Article : Google Scholar

5 

Tukaj S and Wegrzyn G: Anti-Hsp90 therapy in autoimmune and inflammatory diseases: A review of preclinical studies. Cell Stress Chaperones. 21:213–218. 2016.PubMed/NCBI View Article : Google Scholar

6 

Schopf FH, Biebl MM and Buchner J: The HSP90 chaperone machinery. Nat Rev Mol Cell Biol. 18:345–360. 2017.PubMed/NCBI View Article : Google Scholar

7 

Wu J, Liu T, Rios Z, Mei Q, Lin X and Cao S: Heat shock proteins and cancer. Trends Pharmacol Sci. 38:226–256. 2017.PubMed/NCBI View Article : Google Scholar

8 

Usmani SZ, Bona RD, Chiosis G and Li Z: The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1. J Hematol Oncol. 3(40)2010.PubMed/NCBI View Article : Google Scholar

9 

Haque A, Alam Q, Alam MZ, Azhar EI, Sait KH, Anfinan N, Mushtaq G, Kamal MA and Rasool M: Current understanding of HSP90 as a novel therapeutic target: An emerging approach for the treatment of cancer. Curr Pharm Des. 22:2947–2959. 2016.PubMed/NCBI View Article : Google Scholar

10 

Fuhrmann-Stroissnigg H, Ling YY, Zhao J, McGowan SJ, Zhu Y, Brooks RW, Grassi D, Gregg SQ, Stripay JL, Dorronsoro A, et al: Identification of HSP90 inhibitors as a novel class of senolytics. Nat Commun. 8(422)2017.PubMed/NCBI View Article : Google Scholar

11 

Ambade A, Catalano D, Lim A and Mandrekar P: Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice. Hepatology. 55:1585–1595. 2012.PubMed/NCBI View Article : Google Scholar

12 

Ambade A, Catalano D, Lim A, Kopoyan A, Shaffer SA and Mandrekar P: Inhibition of heat shock protein 90 alleviates steatosis and macrophage activation in murine alcoholic liver injury. J Hepatol. 61:903–911. 2014.PubMed/NCBI View Article : Google Scholar

13 

Medzhitov R: Toll-like receptors and innate immunity. Nat Rev Immunol. 1:135–145. 2001.PubMed/NCBI View Article : Google Scholar

14 

Khalafalla MG, Woods LT, Camden JM, Khan AA, Limesand KH, Petris MJ, Erb L and Weisman GA: P2X7 receptor antagonism prevents IL-1β release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. J Biol Chem. 292:16626–16637. 2017.PubMed/NCBI View Article : Google Scholar

15 

Teratani T, Tomita K, Suzuki T, Furuhashi H, Irie R, Hida S, Okada Y, Kurihara C, Ebinuma H, Nakamoto N, et al: Free cholesterol accumulation in liver sinusoidal endothelial cells exacerbates acetaminophen hepatotoxicity via TLR9 signaling. J Hepatol. 67:780–790. 2017.PubMed/NCBI View Article : Google Scholar

16 

Liu B, Yang Y, Qiu Z, Staron M, Hong F, Li Y, Wu S, Li Y, Hao B, Bona R, et al: Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone. Nat Commun. 1(79)2010.PubMed/NCBI View Article : Google Scholar

17 

Wang J, Grishin AV and Ford HR: Experimental anti-inflammatory drug semapimod inhibits TLR signaling by targeting the TLR chaperone gp96. J Immunol. 196:5130–5137. 2016.PubMed/NCBI View Article : Google Scholar

18 

Yu J, Zhang W, Qian H, Tang H, Lin W and Lu B: SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis. Sci Rep. 7(9482)2017.PubMed/NCBI View Article : Google Scholar

19 

Yang J and Lu B: Establishment of a novel rat model of severe acute cholangitis. Iran J Basic Med Sci. 18:1124–1129. 2015.PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

21 

Braet F, De Zanger R, Sasaoki T, Baekeland M, Janssens P, Smedsrød B and Wisse E: Assessment of a method of isolation, purification, and cultivation of rat liver sinusoidal endothelial cells. Lab Invest. 70:944–952. 1994.PubMed/NCBI

22 

Navaneethan U, Jayanthi V and Mohan P: Pathogenesis of cholangitis in obstructive jaundice-revisited. Minerva Gastroenterol Dietol. 57:97–104. 2011.PubMed/NCBI

23 

Mellatyar H, Talaei S, Pilehvar-Soltanahmadi Y, Barzegar A, Akbarzadeh A, Shahabi A, Barekati-Mowahed M and Zarghami N: Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art. Biomed Pharmacother. 102:608–617. 2018.PubMed/NCBI View Article : Google Scholar

24 

Holzbeierlein JM, Windsperger A and Vielhauer G: Hsp90: A drug target? Curr Oncol Rep. 12:95–101. 2010.PubMed/NCBI View Article : Google Scholar

25 

Kim HR, Kang HS and Kim HD: Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells. IUBMB Life. 48:429–433. 1999.PubMed/NCBI View Article : Google Scholar

26 

Wang YL, Shen HH, Cheng PY, Chu YJ, Hwang HR, Lam KK and Lee YM: 17-DMAG, an HSP90 inhibitor, ameliorates multiple organ dysfunction syndrome via induction of HSP70 in endotoxemic rats. PLoS One. 11(e0155583)2016.PubMed/NCBI View Article : Google Scholar

27 

Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, et al: Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem. 49:4606–4615. 2006.PubMed/NCBI View Article : Google Scholar

28 

Vaughan AT, Betti CJ and Villalobos MJ: Surviving apoptosis. Apoptosis. 7:173–177. 2002.PubMed/NCBI View Article : Google Scholar

29 

Li M, Cai SY and Boyer JL: Mechanisms of bile acid mediated inflammation in the liver. Mol Aspects Med. 56:45–53. 2017.PubMed/NCBI View Article : Google Scholar

30 

Tanasescu C: Correlation between cholestasis and infection. Rom J Gastroenterol. 13:23–27. 2004.PubMed/NCBI

31 

Luan J and Ju D: Inflammasome: A double-edged sword in liver diseases. Front Immunol. 9(2201)2018.PubMed/NCBI View Article : Google Scholar

32 

Shetty S, Lalor PF and Adams DH: Liver sinusoidal endothelial cells-gatekeepers of hepatic immunity. Nat Rev Gastroenterol Hepatol. 15:555–567. 2018.PubMed/NCBI View Article : Google Scholar

33 

Cai J, Zhang XJ and Li H: The role of innate immune cells in nonalcoholic steatohepatitis. Hepatology. 70:1026–1037. 2019.PubMed/NCBI View Article : Google Scholar

34 

Roh YS, Zhang B, Loomba R and Seki E: TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration. Am J Physiol Gastrointest Liver Physiol. 309:G30–G41. 2015.PubMed/NCBI View Article : Google Scholar

35 

Madrigal-Matute J, Fernandez-Garcia CE, Gomez-Guerrero C, Lopez-Franco O, Muñoz-Garcia B, Egido J, Blanco-Colio LM and Martin-Ventura JL: HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis. Cardiovasc Res. 95:116–123. 2012.PubMed/NCBI View Article : Google Scholar

36 

Qi J, Liu Y, Yang P, Chen T, Liu XZ, Yin Y, Zhang J and Wang F: Heat shock protein 90 inhibition by 17-dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke. Am J Transl Res. 7:1826–1837. 2015.PubMed/NCBI

37 

Leung AM, Redlak MJ and Miller TA: Role of heat shock proteins in oxygen radical-induced gastric apoptosis. J Surg Res. 193:135–144. 2015.PubMed/NCBI View Article : Google Scholar

38 

Arab JP, Cabrera D and Arrese M: Bile acids in cholestasis and its treatment. Ann Hepatol. 16 (Suppl 1: S3-S105):S53–S57. 2017.PubMed/NCBI View Article : Google Scholar

39 

Liu C, Chen J, Liu B, Yuan S, Shou D, Wen L, Wu X and Gong W: Role of IL-18 in transplant biology. Eur Cytokine Netw. 29:48–51. 2018.PubMed/NCBI View Article : Google Scholar

40 

Bortolotti P, Faure E and Kipnis E: Inflammasomes in tissue damages and immune disorders after trauma. Front Immunol. 9(1900)2018.PubMed/NCBI View Article : Google Scholar

41 

Mende R, Vincent FB, Kandane-Rathnayake R, Koelmeyer R, Lin E, Chang J, Hoi AY, Morand EF, Harris J and Lang T: Analysis of serum interleukin (IL)-1β and IL-18 in systemic lupus erythematosus. Front Immunol. 9(1250)2018.PubMed/NCBI View Article : Google Scholar

42 

Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, Sutterwala FS, Flavell RA and Mehal WZ: Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J Clin Invest. 119:305–314. 2009.PubMed/NCBI View Article : Google Scholar

43 

Khanova E, Wu R, Wang W, Yan R, Chen Y, French SW, Llorente C, Pan SQ, Yang Q, Li Y, et al: Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology. 67:1737–1753. 2018.PubMed/NCBI View Article : Google Scholar

44 

Kader M, Alaoui-El-Azher M, Vorhauer J, Kode BB, Wells JZ, Stolz D, Michalopoulos G, Wells A, Scott M and Ismail N: MyD88-dependent inflammasome activation and autophagy inhibition contributes to Ehrlichia-induced liver injury and toxic shock. PLoS Pathog. 13(e1006644)2017.PubMed/NCBI View Article : Google Scholar

45 

Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, et al: Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis. Gut. 66:507–518. 2017.PubMed/NCBI View Article : Google Scholar

46 

Mridha AR, Haczeyni F, Yeh MM, Haigh WG, Ioannou GN, Barn V, Ajamieh H, Adams L, Hamdorf JM, Teoh NC and Farrell GC: TLR9 is up-regulated in human and murine NASH: Pivotal role in inflammatory recruitment and cell survival. Clin Sci (Lond). 131:2145–2159. 2017.PubMed/NCBI View Article : Google Scholar

47 

Li L, Wang L, You QD and Xu XL: Heat shock protein 90 inhibitors: An update on achievements, challenges, and future directions. J Med Chem. 63:1798–1822. 2020.PubMed/NCBI View Article : Google Scholar

48 

Ramanathan RK, Egorin MJ, Erlichman C, Remick SC, Ramalingam SS, Naret C, Holleran JL, TenEyck CJ, Ivy SP and Belani CP: Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors. J Clin Oncol. 28:1520–1526. 2010.PubMed/NCBI View Article : Google Scholar

49 

Lancet JE, Gojo I, Burton M, Quinn M, Tighe SM, Kersey K, Zhong Z, Albitar MX, Bhalla K, Hannah AL and Baer MR: Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia. Leukemia. 24:699–705. 2010.PubMed/NCBI View Article : Google Scholar

50 

Kummar S, Gutierrez ME, Gardner ER, Chen X, Figg WD, Zajac-Kaye M, Chen M, Steinberg SM, Muir CA, Yancey MA, et al: Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies. Eur J Cancer. 46:340–347. 2010.PubMed/NCBI View Article : Google Scholar

51 

Jhaveri K, Miller K, Rosen L, Schneider B, Chap L, Hannah A, Zhong Z, Ma W, Hudis C and Modi S: A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors. Clin Cancer Res. 18:5090–5098. 2012.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tong C, Li J, Lin W, Cen W, Zhang W, Zhu Z, Lu B and Yu J: Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression. Exp Ther Med 21: 241, 2021.
APA
Tong, C., Li, J., Lin, W., Cen, W., Zhang, W., Zhu, Z. ... Yu, J. (2021). Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression. Experimental and Therapeutic Medicine, 21, 241. https://doi.org/10.3892/etm.2021.9672
MLA
Tong, C., Li, J., Lin, W., Cen, W., Zhang, W., Zhu, Z., Lu, B., Yu, J."Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression". Experimental and Therapeutic Medicine 21.3 (2021): 241.
Chicago
Tong, C., Li, J., Lin, W., Cen, W., Zhang, W., Zhu, Z., Lu, B., Yu, J."Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression". Experimental and Therapeutic Medicine 21, no. 3 (2021): 241. https://doi.org/10.3892/etm.2021.9672
Copy and paste a formatted citation
x
Spandidos Publications style
Tong C, Li J, Lin W, Cen W, Zhang W, Zhu Z, Lu B and Yu J: Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression. Exp Ther Med 21: 241, 2021.
APA
Tong, C., Li, J., Lin, W., Cen, W., Zhang, W., Zhu, Z. ... Yu, J. (2021). Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression. Experimental and Therapeutic Medicine, 21, 241. https://doi.org/10.3892/etm.2021.9672
MLA
Tong, C., Li, J., Lin, W., Cen, W., Zhang, W., Zhu, Z., Lu, B., Yu, J."Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression". Experimental and Therapeutic Medicine 21.3 (2021): 241.
Chicago
Tong, C., Li, J., Lin, W., Cen, W., Zhang, W., Zhu, Z., Lu, B., Yu, J."Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL‑1β and IL‑18 expression". Experimental and Therapeutic Medicine 21, no. 3 (2021): 241. https://doi.org/10.3892/etm.2021.9672
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team