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Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study

  • Authors:
    • Zheling Chen
    • Minyao Ge
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    Affiliations: Department of Traditional Chinese Medicine, Zhenxin Community Health Service Center, Shanghai 201824, P.R. China, Department of Urology Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 242
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    Published online on: January 22, 2021
       https://doi.org/10.3892/etm.2021.9673
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Abstract

Benign prostate hyperplasia (BPH) is one of the well‑known urological neoplasms common in males with an increasing number of associated deaths in aging males. It causes uncomfortable urinary symptoms, including urine flow blockage, and may cause bladder, urinary tract or kidney problems. The histopathological and clinical knowledge regarding BPH is limited. In the present study, an in silico approach was applied that uses genome‑scale microarray expression data to discover a wide range of protein‑protein interactions in addition to focusing on specific genes responsible for BPH to develop prognostic biomarkers. Various genes that were differentially expressed in BPH were identified. Gene and functional annotation clusters were determined and an interaction analysis with disease phenotypes of BPH was performed, as well as an RNA tissue specificity analysis. Furthermore, a molecular docking study of certain short‑listed gene biomarkers, namely anterior gradient 2 (AGR2; PDB ID: 2LNT), steroid 5α‑reductase 2 (PDB ID: 6OQX), zinc finger protein 3 (PDB ID: 5T00) and collagen type XII α1 chain (PDB ID: 1U5M), was performed in order to identify alternative Chinese herbal agents for the treatment of BPH. Data from the present study revealed that AGR2 receptor (PDB ID: 2LNT) and berberine (Huang Bo) form the most stable complex and therefore may be assessed in further pharmacological studies for the treatment of BPH.
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1 

Lorenzo G, Hughes TJR, Dominguez-Frojan P, Reali A and Gomez H: Computer simulations suggest that prostate enlargement due to benign prostatic hyperplasia mechanically impedes prostate cancer growth. Proc Natl Acad Sci USA. 116:1152–1161. 2019.PubMed/NCBI View Article : Google Scholar

2 

NIH-NIDDK. Prostate Enlargement (Benign Prostatic Hyperplasia)|NIDDK [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases. 2019 [cited 2020 Jan 16]. Available from: https://www.niddk.nih.gov/health-information/urologic-diseases/prostate-problems/prostate-enlargement-benign-prostatic-hyperplasia.

3 

Nicholson TM and Ricke WA: Androgens and estrogens in benign prostatic hyperplasia: Past, present and future. Differentiation. 82:184–199. 2011.PubMed/NCBI View Article : Google Scholar

4 

Hata J, Satoh Y, Akaihata H, Hiraki H, Ogawa S, Haga N, Ishibashi K, Aikawa K and Kojima Y: Molecular classification of benign prostatic hyperplasia: A gene expression profiling study in a rat model. Int J Urol. 23:599–612. 2016.PubMed/NCBI View Article : Google Scholar

5 

Dai X, Fang X, Ma Y and Xianyu J: Benign prostatic hyperplasia and the risk of prostate cancer and bladder cancer: A meta-analysis of observational studies. Medicine (Baltimore). 95(e3493)2016.PubMed/NCBI View Article : Google Scholar

6 

Miah S and Catto J: BPH and prostate cancer risk. Indian J Urol. 30:214–218. 2014.PubMed/NCBI View Article : Google Scholar

7 

Chughtai B, Forde JC, Thomas DD, Laor L, Hossack T, Woo HH, Te AE and Kaplan SA: Benign prostatic hyperplasia. Nat Rev Dis Primers. 2(16031)2016.PubMed/NCBI View Article : Google Scholar

8 

Kim EH, Larson JA and Andriole GL: Management of benign prostatic hyperplasia. Annu Rev Med. 67:137–151. 2016.PubMed/NCBI View Article : Google Scholar

9 

Barry MJ, Fowler FJ, O'Leary MP, Bruskewitz RC, Holtgrewe HL and Mebust WK: Measuring disease-specific health status in men with benign prostatic hyperplasia. Measurement committee of the American urological association. Med Care. 33 (Suppl 4):AS145–AS155. 1995.PubMed/NCBI

10 

Rawla P: Epidemiology of prostate cancer. World J Oncol. 10:63–89. 2019.PubMed/NCBI View Article : Google Scholar

11 

Levitt JM and Slawin KM: Prostate-specific antigen and prostate-specific antigen derivatives as predictors of benign prostatic hyperplasia progression. Curr Urol Rep. 8:269–274. 2007.PubMed/NCBI View Article : Google Scholar

12 

Nickel JC, Aaron L, Barkin J, Elterman D, Nachabé M and Zorn KC: Canadian urological association guideline on male lower urinary tract symptoms/benign prostatic hyperplasia (MLUTS/BPH): 2018 update. Can Urol Assoc J. 12:303–312. 2018.PubMed/NCBI View Article : Google Scholar

13 

Chen J, Zhang D, Yan W, Yang D and Shen B: Translational bioinformatics for diagnostic and prognostic prediction of prostate cancer in the next-generation sequencing era. Biomed Res Int. 2013(901578)2013.PubMed/NCBI View Article : Google Scholar

14 

Mobley RE and Bizzarro MJ: Central line-associated bloodstream infections in the NICU: Successes and controversies in the quest for zero. Semin Perinatol. 41:166–174. 2017.PubMed/NCBI View Article : Google Scholar

15 

Tacklind J, Fink HA, Macdonald R, Rutks I and Wilt TJ: Finasteride for benign prostatic hyperplasia. Cochrane Database Syst Rev. 6(CD006015)2010.PubMed/NCBI View Article : Google Scholar

16 

Michel MC and Vrydag W: Alpha1-, alpha2- and beta-adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol. 147 (Suppl 2):S88–S119. 2006.PubMed/NCBI View Article : Google Scholar

17 

Yadav SS, Li J, Lavery HJ, Yadav KK and Tewari AK: Next-generation sequencing technology in prostate cancer diagnosis, prognosis, and personalized treatment. Urol Oncol. 33:267.e1–e13. 2015.PubMed/NCBI View Article : Google Scholar

18 

Yu ZJ, Yan HL, Xu FH, Chao HC, Deng LH, Xu XD, Huang JB and Zeng T: Efficacy and side effects of drugs commonly used for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. Front Pharmacol. 11(658)2020.PubMed/NCBI View Article : Google Scholar

19 

Davis S and Meltzer PS: GEOquery: A bridge between the gene expression omnibus (GEO) and BioConductor. Bioinformatics. 23:1846–1847. 2007.PubMed/NCBI View Article : Google Scholar

20 

Smyth GK: Limma: Linear models for microarray data. In: Gentleman R, Carey VJ, Huber W, Irizarry RA and Dudoit S (eds): Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Statistics for Biology and Health, Springer, New York, NY, pp397-420, 2005.

21 

Huang DW, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009.PubMed/NCBI View Article : Google Scholar

22 

Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, et al: The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 38:W214–W220. 2010.PubMed/NCBI View Article : Google Scholar

23 

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, et al: Proteomics. Tissue-based map of the human proteome. Science. 347(1260419)2015.PubMed/NCBI View Article : Google Scholar

24 

Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B and Overington JP: ChEMBL: A large-scale bioactivity database for drug discovery. Nucleic Acids Res. 40:D1100–D1107. 2012.PubMed/NCBI View Article : Google Scholar

25 

Kim S, Thiessen PA, Bolton EE, Chen J, Fu G, Gindulyte A, Han L, He J, He S, Shoemaker BA, et al: PubChem substance and compound databases. Nucleic Acids Res. 44:D1202–D1213. 2016.PubMed/NCBI View Article : Google Scholar

26 

Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B and Hassanali M: DrugBank: A knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 36:D901–D906. 2008.PubMed/NCBI View Article : Google Scholar

27 

Trott O and Olson AJ: AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem. 31:455–461. 2010.PubMed/NCBI View Article : Google Scholar

28 

Salentin S, Schreiber S, Haupt VJ, Adasme MF and Schroeder M: PLIP: Fully automated protein-ligand interaction profiler. Nucleic Acids Res. 43:W443–W447. 2015.PubMed/NCBI View Article : Google Scholar

29 

Schena M, Shalon D, Davis RW and Brown PO: Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science. 270:467–470. 1995.PubMed/NCBI View Article : Google Scholar

30 

Draghici S: Data Analysis Tools for DNA Microarrays. Chapman and Hall/CRC Press, Boca Raton (FL), 2003. Available from: https://trove.nla.gov.au/version/46530985.

31 

Raza K: Reconstruction, topological and gene ontology enrichment analysis of cancerous gene regulatory network modules. Curr Bioinform. 11:243–258. 2016.

32 

Raza K and Hasan AN: A comprehensive evaluation of machine learning techniques for cancer class prediction based on microarray data. Int J Bioinform Res Appl. 11:397–416. 2015.PubMed/NCBI View Article : Google Scholar

33 

Raza K: Analysis of microarray data using artificial intelligence based techniques. In: Handbook of Research on Computational Intelligence Applications in Bioinformatics, pp216-239, 2016.

34 

Cross NA, Chandrasekharan S, Jokonya N, Fowles A, Hamdy FC, Buttle DJ and Eaton CL: The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: Relevance to the accumulation of versican. Prostate. 63:269–275. 2005.PubMed/NCBI View Article : Google Scholar

35 

Burger MJ, Tebay MA, Keith PA, Samaratunga HM, Clements J, Lavin MF and Gardiner RA: Expression analysis of delta-catenin and prostate-specific membrane antigen: Their potential as diagnostic markers for prostate cancer. Int J Cancer. 100:228–237. 2002.PubMed/NCBI View Article : Google Scholar

36 

Cohen P, Peehl DM, Baker B, Liu F, Hintz RL and Rosenfeld RG: Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia. J Clin Endocrinol Metab. 79:1410–1415. 1994.PubMed/NCBI View Article : Google Scholar

37 

Piñero J, Ramírez-Anguita JM, Saüch-Pitarch J, Ronzano F, Centeno E, Sanz F and Furlong LI: The DisGeNET knowledge platform for disease genomics: 2019 update. Nucleic Acids Res. 48:D845–D855. 2020.PubMed/NCBI View Article : Google Scholar

38 

Gustavsson H, Tesan T, Jennbacken K, Kuno K, Damber JE and Welén K: ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors. BMC Cancer. 10(288)2010.PubMed/NCBI View Article : Google Scholar

39 

Chen Y, Wang J, Fraig MM, Metcalf J, Turner WR, Bissada NK, Watson DK and Schweinfest CW: Defects of DNA mismatch repair in human prostate cancer. Cancer Res. 61:4112–4121. 2001.PubMed/NCBI

40 

Armenia J, Wankowicz SAM, Liu D, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, et al: The long tail of oncogenic drivers in prostate cancer. Nat Genet. 50:645–651. 2018.PubMed/NCBI View Article : Google Scholar

41 

Morgenbesser SD, McLaren RP, Richards B, Zhang M, Akmaev VR, Winter SF, Mineva ND, Kaplan-Lefko PJ, Foster BA, Cook BP, et al: Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model. Prostate. 67:83–106. 2007.PubMed/NCBI View Article : Google Scholar

42 

Maresh EL, Mah V, Alavi M, Horvath S, Bagryanova L, Liebeskind ES, Knutzen LA, Zhou Y, Chia D, Liu AY and Goodglick L: Differential expression of anterior gradient gene AGR2 in prostate cancer. BMC Cancer. 10(680)2010.PubMed/NCBI View Article : Google Scholar

43 

Bu H, Bormann S, Schäfer G, Horninger W, Massoner P, Neeb A, Lakshmanan VK, Maddalo D, Nestl A, Sültmann H, et al: The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection. Prostate. 71:575–587. 2011.PubMed/NCBI View Article : Google Scholar

44 

Neeb A, Hefele S, Bormann S, Parson W, Adams F, Wolf P, Miernik A, Schoenthaler M, Kroenig M, Wilhelm K, et al: Splice variant transcripts of the anterior gradient 2 gene as a marker of prostate cancer. Oncotarget. 5:8681–8689. 2014.PubMed/NCBI View Article : Google Scholar

45 

Paschke L, Rucinski M, Ziolkowska A, Zemleduch T, Malendowicz W, Kwias Z and Malendowicz LK: ZFP91-a newly described gene potentially involved in prostate pathology. Pathol Oncol Res. 20:453–459. 2014.PubMed/NCBI View Article : Google Scholar

46 

Jiang H, Zhang L, Liu J, Chen Z, Na R, Ding G, Zhang H and Ding Q: Knockdown of zinc finger protein X-linked inhibits prostate cancer cell proliferation and induces apoptosis by activating caspase-3 and caspase-9. Cancer Gene Ther. 19:684–689. 2012.PubMed/NCBI View Article : Google Scholar

47 

Vanaja DK, Cheville JC, Iturria SJ and Young CY: Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression. Cancer Res. 63:3877–3882. 2003.PubMed/NCBI

48 

Abildgaard MO, Borre M, Mortensen MM, Ulhøi BP, Tørring N, Wild P, Kristensen H, Mansilla F, Ottosen PD, Dyrskjøt L, et al: Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis. Int J Cancer. 130:885–895. 2012.PubMed/NCBI View Article : Google Scholar

49 

Jiao L, Li Y, Shen D, Xu C, Wang L, Huang G, Chen L, Yang Y, Yang C, Yu Y and Sun Y: The prostate cancer-up-regulated Myc-associated zinc-finger protein (MAZ) modulates proliferation and metastasis through reciprocal regulation of androgen receptor. Med Oncol. 30(570)2013.PubMed/NCBI View Article : Google Scholar

50 

Rahman MT: Zinc and benign prostatic hyperplasia (BPH) & prostate cancer (PCa) association. Med Res Arch. 4:1–16. 2016.

51 

Dunn TA, Fedor HL, De Marzo AM and Luo J: Molecular profiling of indolent human prostate cancer: Tackling technical challenges to achieve high-fidelity genome-wide data. Asian J Androl. 14:385–392. 2012.PubMed/NCBI View Article : Google Scholar

52 

O'Malley KJ, Eisermann K, Pascal LE, Parwani AV, Majima T, Graham L, Hrebinko K, Acquafondata M, Stewart NA, Nelson JB, et al: Proteomic analysis of patient tissue reveals PSA protein in the stroma of benign prostatic hyperplasia. Prostate. 74:892–900. 2014.PubMed/NCBI View Article : Google Scholar

53 

Adeola HA, Calder B, Soares NC, Kaestner L, Blackburn JM and Zerbini LF: In silico verification and parallel reaction monitoring prevalidation of potential prostate cancer biomarkers. Future Oncol. 12:43–57. 2015.PubMed/NCBI View Article : Google Scholar

54 

Sacca PA, Mazza ON, Scorticati C, Vitagliano G, Casas G and Calvo JC: Human periprostatic adipose tissue: Secretome from patients with prostate cancer or benign prostate hyperplasia. Cancer Genomics Proteomics. 16:29–58. 2019.PubMed/NCBI View Article : Google Scholar

55 

Hsing AW, Chen C, Chokkalingam AP, Gao YT, Dightman DA, Nguyen HT, Deng J, Cheng J, Sesterhenn IA, Mostofi FK, et al: Polymorphic markers in the SRD5A2 gene and prostate cancer risk: A population-based case-control study. Cancer Epidemiol Biomarkers Prev. 10:1077–102. 2001.PubMed/NCBI

56 

Choi SY, Kim HJ, Cheong HS and Myung SC: The association of 5-alpha reductase type 2 (SRD5A2) gene polymorphisms with prostate cancer in a Korean population. Korean J Urol. 56:19–30. 2015.PubMed/NCBI View Article : Google Scholar

57 

Choubey VK, Sankhwar SN, Carlus SJ, Singh AN, Dalela D, Thangaraj K and Rajender S: SRD5A2 gene polymorphisms and the risk of benign prostatic hyperplasia but not prostate cancer. Asian Pac J Cancer Prev. 16:1033–1036. 2015.PubMed/NCBI View Article : Google Scholar

58 

Zeng XT, Su XJ, Li S, Weng H, Liu TZ and Wang XH: Association between SRD5A2 rs523349 and rs9282858 polymorphisms and risk of benign prostatic hyperplasia: A meta-analysis. Front Physiol. 8(688)2017.PubMed/NCBI View Article : Google Scholar

59 

Lodewijk L, Willems SM, Dreijerink KMA, de Keizer B, van Diest PJ, Schepers A, Morreau H, Bonenkamp HJ, Van Engen-van Grunsven IACH, Kruijff S, et al: The theranostic target prostate-specific membrane antigen is expressed in medullary thyroid cancer. Hum Pathol. 81:245–254. 2018.PubMed/NCBI View Article : Google Scholar

60 

Sácha P, Zámecník J, Barinka C, Hlouchová K, Vícha A, Mlcochová P, Hilgert I, Eckschlager T and Konvalinka J: Expression of glutamate carboxypeptidase II in human brain. Neuroscience. 144:1361–1372. 2007.PubMed/NCBI View Article : Google Scholar

61 

O'Keefe DS, Bacich DJ and Heston WD: Comparative analysis of prostate-specific membrane antigen (PSMA) versus a prostate-specific membrane antigen-like gene. Prostate. 58:200–210. 2004.PubMed/NCBI View Article : Google Scholar

62 

Kinoshita Y, Kuratsukuri K, Landas S, Imaida K, Rovito PM Jr, Wang CY and Haas GP: Expression of prostate-specific membrane antigen in normal and malignant human tissues. World J Surg. 30:628–636. 2006.PubMed/NCBI View Article : Google Scholar

63 

Kumar R, Verma V, Sarswat A, Maikhuri JP, Jain A, Jain RK, Sharma VL, Dalela D and Gupta G: Selective estrogen receptor modulators regulate stromal proliferation in human benign prostatic hyperplasia by multiple beneficial mechanisms-action of two new agents. Invest New Drugs. 30:582–593. 2012.PubMed/NCBI View Article : Google Scholar

64 

Huang DW, Sherman BT, Tan Q, Collins JR, Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC and Lempicki RA: The DAVID gene functional classification tool: A novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 8(R183)2007.PubMed/NCBI View Article : Google Scholar

65 

Raza K: Protein features identification for machine learning-based prediction of protein-protein interactions. In: International Conference on Information, Communication and Computing Technology, pp305-317, 2017.

66 

Raza K and Parveen R: Soft computing approach for modeling genetic regulatory networks. In: Advances in Computing and Information Technology. Advances in Intelligent Systems and Computing. Meghanathan N, Nagamalai D and Chaki N (eds). Springer, Berlin, Heidelberg, pp1-11, 2013.

67 

Raza K and Parveen R: Reconstruction of gene regulatory network of colon cancer using information theoretic approach. In: Confluence 2013: The Next Generation Information Technology Summit (4th International Conference), pp461-466, 2013.

68 

Kryuchkova-Mostacci N and Robinson-Rechavi M: A benchmark of gene expression tissue-specificity metrics. Brief Bioinform. 18:205–214. 2017.PubMed/NCBI View Article : Google Scholar

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Spandidos Publications style
Chen Z and Ge M: Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study. Exp Ther Med 21: 242, 2021.
APA
Chen, Z., & Ge, M. (2021). Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study. Experimental and Therapeutic Medicine, 21, 242. https://doi.org/10.3892/etm.2021.9673
MLA
Chen, Z., Ge, M."Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study". Experimental and Therapeutic Medicine 21.3 (2021): 242.
Chicago
Chen, Z., Ge, M."Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study". Experimental and Therapeutic Medicine 21, no. 3 (2021): 242. https://doi.org/10.3892/etm.2021.9673
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Z and Ge M: Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study. Exp Ther Med 21: 242, 2021.
APA
Chen, Z., & Ge, M. (2021). Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study. Experimental and Therapeutic Medicine, 21, 242. https://doi.org/10.3892/etm.2021.9673
MLA
Chen, Z., Ge, M."Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study". Experimental and Therapeutic Medicine 21.3 (2021): 242.
Chicago
Chen, Z., Ge, M."Discovering pathways in benign prostate hyperplasia: A functional genomics pilot study". Experimental and Therapeutic Medicine 21, no. 3 (2021): 242. https://doi.org/10.3892/etm.2021.9673
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