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Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome

  • Authors:
    • Na Jiang
    • Shulong Zhou
    • Guanglei Wang
    • Ningning Jiang
    • Huaixin Wang
    • Feng Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China, Department of Ophthalmology, Yidu Central Hospital of Weifang, Weifang, Shandong 262500, P.R. China, Department of Cardiology, Dongying Hospital of Traditional Chinese Medicine, Dongying, Shandong 257000, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 254
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    Published online on: January 25, 2021
       https://doi.org/10.3892/etm.2021.9685
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Abstract

The present study aimed to explore the diagnostic value and prognostic significance of C1q/tumor necrosis factor‑related protein 9 (CTRP9) combined with pentraxin‑3 (PTX‑3) in acute coronary syndrome (ACS). A total of 137 patients with coronary heart disease and chest pain were included. Among them, seventy‑nine patients with ACS were allocated into a study group and fifty‑eight patients with non‑cardiac chest pain (NCCP) were allocated into a control group. The serum CTRP9, PTX‑3 levels were quantified by ELISA, and their correlation with other ACS‑related indexes, diagnostic value for ACS and predictive significance for poor prognosis were analyzed. In addition, the risk factors of the poor prognosis of ACS patients were studied. CTRP9 was lowly expressed and PTX‑3 was highly expressed in the serum of ACS patients. CTRP9 was negatively correlated with cardiac troponin I (cTnI), creatine kinase‑MB (CK‑MB) and high‑sensitivity C‑reactive protein (hs‑CRP) (P<0.05), while PTX‑3 was positively correlated with them (P<0.05). Combined detection of CTRP9 and PTX‑3 was of high value in the diagnosis and prognosis of ACS patients. In addition, CTRP9 and PTX‑3 were independent risk factors for the poor prognosis of ACS. Patients with ACS had lower CTRP9 expression and higher PTX‑3 expression than those without ACS. Moreover, the combined detection of CTRP9 and PTX‑3 can better evaluate the diagnosis and prognosis of ACS patients.
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1 

Cuisset T, Deharo P, Quilici J, Johnson TW, Deffarges S, Bassez C, Bonnet G, Fourcade L, Mouret JP, Lambert M, et al: Benefit of switching dual antiplatelet therapy after acute coronary syndrome: The TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study. Eur Heart J. 38:3070–3078. 2017.PubMed/NCBI View Article : Google Scholar

2 

Kai ME and Lindahl B: Application of cardiac troponin in cardiovascular diseases other than acute coronary syndrome. Clin Chem. 63:223–235. 2017.PubMed/NCBI View Article : Google Scholar

3 

Hamm CW, Bertrand M and Braunwald E: Acute coronary syndrome without ST elevation: Implementation of the new guidelines. Lancet. 358:1533–1538. 2001.PubMed/NCBI View Article : Google Scholar

4 

Katus H, Ziegler A, Ekinci O, Giannitsis E, Stough WG, Achenbach S, Blankenberg S, Brueckmann M, Collinson P, Comaniciu D, et al: Early diagnosis of acute coronary syndrome. Eur Heart J. 38:3049–3055. 2017.PubMed/NCBI View Article : Google Scholar

5 

Mishra B, Pandey S, Niraula SR, Rai BK, Karki P, Baral N and Lamsal M: Utility of ischemia modified albumin as an early marker for diagnosis of acute coronary syndrome. J Nepal Health Res Counc. 16:16–21. 2018.PubMed/NCBI

6 

Peterson JM, Wei Z, Seldin MM, Byerly MS, Aja S and Wong GW: CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol. 305:R522–R533. 2013.PubMed/NCBI View Article : Google Scholar

7 

Li J, Zhang P, Li T, Liu Y, Zhu Q, Chen T, Liu T, Huang C, Zhang J, Zhang Y and Guo Y: CTRP9 enhances carotid plaque stability by reducing pro-inflammatory cytokines in macrophages. Biochem Biophys Res Commun. 458:890–895. 2015.PubMed/NCBI View Article : Google Scholar

8 

Liu T, Guo Y, Li T, Zhang J, Li J and Zhang P: Association of serum CTRP9 and APN levels with acute coronary syndrome. J Shandong Univ. 52:58–62. 2014.

9 

Gao C, Zhao S, Lian K, Mi B, Si R, Tan Z, Fu F, Wang S, Wang R, Ma X and Tao L: C1q/TNF-related protein 3 (CTRP3) and 9 (CTRP9) concentrations are decreased in patients with heart failure and are associated with increased morbidity and mortality. BMC Cardiovasc Disord. 19(139)2019.PubMed/NCBI View Article : Google Scholar

10 

George M, Shanmugam E, Srivatsan V, Vasanth K, Ramraj B, Rajaram M, Jena A, Sridhar A, Chaudhury M and Kaliappan I: Value of pentraxin-3 and galectin-3 in acute coronary syndrome: A short-term prospective cohort study. Ther Adv Cardiovasc Dis. 9(275)2015.PubMed/NCBI View Article : Google Scholar

11 

Barazzoni R, Aleksova A, Carriere C, Cattin MR, Zanetti M, Vinci P, Stolfo D, Guarnieri G and Sinagra G: Obesity and high waist circumference are associated with low circulating pentraxin-3 in acute coronary syndrome. Cardiovasc Diabetol. 12:167. 2013.PubMed/NCBI View Article : Google Scholar

12 

Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE Jr, Chavey WE II, Fesmire FM, Hochman JS, Levin TN, et al: 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 61:e179–e347. 2013.PubMed/NCBI View Article : Google Scholar

13 

Mehrshad V: State-of-the-art diagnosis of myocardial infarction. Diagnosis (Berl). 3:137–142. 2016.PubMed/NCBI View Article : Google Scholar

14 

Panovský R, Borová J, Pleva M, Feitová V, Novotný P, Kincl V, Holeček T, Meluzín J, Sochor O and Štěpánová R: The unique value of cardiovascular magnetic resonance in patients with suspected acute coronary syndrome and culprit-free coronary angiograms. BMC Cardiovasc Disord. 17(170)2017.PubMed/NCBI View Article : Google Scholar

15 

Chacko S, Haseeb S, Glover BM, Wallbridge D and Harper A: The role of biomarkers in the diagnosis and risk stratification of acute coronary syndrome. Future Sci Oa. 4(FSO251)2018.PubMed/NCBI View Article : Google Scholar

16 

Wang W, Ren D, Wang CS and Yao HC: Nardilysin: A potential biomarker for the early diagnosis of acute coronary syndrome. Int J Cardiol. 265(39)2018.PubMed/NCBI View Article : Google Scholar

17 

Choi KM, Hwang SY, Hong HC, Choi HY, Yoo HJ, Youn BS, Baik SH and Seo HS: Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris. Cardiovasc Diabetol. 13(14)2014.PubMed/NCBI View Article : Google Scholar

18 

Gustin C, Delaive E, Dieu M, Calay D and Raes M: Up-regulation of pentraxin-3 in human endothelial cells after lysophosphatidic acid exposure. Arterioscler Thromb Vasc Biol. 28:491–497. 2008.PubMed/NCBI View Article : Google Scholar

19 

Kotooka N, Inoue T, Aoki S, Anan M, Komoda H and Node K: Prognostic value of pentraxin 3 in patients with chronic heart failure. Int J Cardiol. 130:19–22. 2008.PubMed/NCBI View Article : Google Scholar

20 

Hasic S, Kadic D, Kiseljakovic E, Jadric R and Spahic E: Serum uric acid could differentiate acute myocardial infarction and unstable angina pectoris in hyperuricemic acute coronary syndrome patients. Med Arch. 71:115–118. 2017.PubMed/NCBI View Article : Google Scholar

21 

Natsukawa T, Maeda N, Fukuda S, Yamaoka M, Fujishima Y, Nagao H, Sato F, Nishizawa H, Sawano H, Hayashi Y, et al: Significant association of serum adiponectin and creatine kinase-MB levels in ST-segment elevation myocardial infarction. J Atheroscler Thromb. 24:793–803. 2017.PubMed/NCBI View Article : Google Scholar

22 

Hong YJ, Jeong MH, Choi YH, Cho SH, Hwang SH, Ko JS, Lee MG, Park KH, Sim DS, Yoon NS, et al: Relation between high-sensitivity C-reactive protein and coronary plaque components in patients with acute coronary syndrome: Virtual histology-intravascular ultrasound analysis. Korean Circ J. 41:440–446. 2011.PubMed/NCBI View Article : Google Scholar

23 

Cheng GD: RDW value for assessment of the severity of acute coronary syndrome and its correlation with serum indexes. J Hainan Med Univ, 2016.

24 

Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, et al: CTRP9protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism. J Biol Chem. 287:18965–18973. 2012.PubMed/NCBI View Article : Google Scholar

25 

Uemura Y, Shibata R, Ohashi K, Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K, et al: Adipose-derived factor CTRP9atenuates vascular smooth muscle cell proliferation and neointimal formation. FASEB J. 27:25–33. 2013.PubMed/NCBI View Article : Google Scholar

26 

Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, et al: C1q/tumor necrosis factor-related protein 9 protects against acute myocardial injury through an adiponectin receptor I-AMPK-dependent mechanism. Mol Cel Biol. 35:2173–2185. 2015.PubMed/NCBI View Article : Google Scholar

27 

Niemann B, Li L, Siegler D, Siegler BH, Knapp F, Hanna J, Aslam M, Kracht M, Schulz R and Rohrbach S: CTRP9 mediates protective effects in cardiomyocytes via AMPK- and adiponectin receptor-mediated induction of anti-oxidant response. Cells. 9(1229)2020.PubMed/NCBI View Article : Google Scholar

28 

Eggers KM, Armstrong PW, Califf RM, Johnston N, Simoons ML, Venge P and James S: Clinical and prognostic implications of circulating pentraxin 3 levels in non ST-elevation acute coronary syndrome. Clin Biochem. 46:1655–1659. 2013.PubMed/NCBI View Article : Google Scholar

29 

Inoue K, Sugiyama A, Reid PC, Ito Y, Miyauchi K, Mukai S, Safara M, Miyamoto K, Satoh H, Kohno I, et al: Establishmen of a high sensitivity plasma assay for human pentraxin 3 as a marker for unstable angina pectoris. Arterioscler Thromb Vasc Biol. 27:161–167. 2007.PubMed/NCBI View Article : Google Scholar

30 

Khamitova AF, Lakman IA, Akhmetvaleev RR, Tulbaev EL, Gareeva DF, Zagidullin SZ and Zagidullin NS: Multifactor predictive model in patients with myocardial infarction based on modern biomarkers. Kardiologiia. 60:14–20. 2020.PubMed/NCBI View Article : Google Scholar : (In Russian).

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Copy and paste a formatted citation
Spandidos Publications style
Jiang N, Zhou S, Wang G, Jiang N, Wang H and Zhao F: Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome. Exp Ther Med 21: 254, 2021.
APA
Jiang, N., Zhou, S., Wang, G., Jiang, N., Wang, H., & Zhao, F. (2021). Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome. Experimental and Therapeutic Medicine, 21, 254. https://doi.org/10.3892/etm.2021.9685
MLA
Jiang, N., Zhou, S., Wang, G., Jiang, N., Wang, H., Zhao, F."Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome". Experimental and Therapeutic Medicine 21.3 (2021): 254.
Chicago
Jiang, N., Zhou, S., Wang, G., Jiang, N., Wang, H., Zhao, F."Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome". Experimental and Therapeutic Medicine 21, no. 3 (2021): 254. https://doi.org/10.3892/etm.2021.9685
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang N, Zhou S, Wang G, Jiang N, Wang H and Zhao F: Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome. Exp Ther Med 21: 254, 2021.
APA
Jiang, N., Zhou, S., Wang, G., Jiang, N., Wang, H., & Zhao, F. (2021). Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome. Experimental and Therapeutic Medicine, 21, 254. https://doi.org/10.3892/etm.2021.9685
MLA
Jiang, N., Zhou, S., Wang, G., Jiang, N., Wang, H., Zhao, F."Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome". Experimental and Therapeutic Medicine 21.3 (2021): 254.
Chicago
Jiang, N., Zhou, S., Wang, G., Jiang, N., Wang, H., Zhao, F."Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome". Experimental and Therapeutic Medicine 21, no. 3 (2021): 254. https://doi.org/10.3892/etm.2021.9685
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