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Article

Inherited thrombophilia is significantly associated with severe preeclampsia

  • Authors:
    • Roxana Elena Bohiltea
    • Monica Mihaela Cirstoiu
    • Natalia Turcan
    • Anca Pantea Stoian
    • Corina-Aurelia Zugravu
    • Octavian Munteanu
    • Luciana Valentina Arsene
    • Bodean Oana
    • Adrian Neacsu
    • Florentina Furtunescu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Obstetrics and Gynecology, University Emergency Hospital Bucharest, 050098 Bucharest, Romania, Department of Diabetes, Nutrition and Metabolic Diseases, ‘Carol Davila’ University of Medicine and Pharmacy, 020475 Bucharest, Romania, Department of Food Hygiene and Nutrition, ‘Carol Davila’ University of Medicine and Pharmacy, 050463 Bucharest, Romania, Department of Public Health and Management, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050463 Bucharest, Romania
  • Article Number: 261
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    Published online on: January 25, 2021
       https://doi.org/10.3892/etm.2021.9691
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Abstract

Methods to prevent the development of pathologies due to placental dysfunctions, such as gestational hypertension and preeclampsia, are the main approaches for obtaining the best maternal and fetal antepartum and postpartum prognosis. During 5 years of study (January, 2015 to December, 2019), the cases of pregnancy and puerperium complicated with pathology due to placental dysfunction were analyzed. The main objective was to determine the magnitude of the impact of thrombophilia on the development of an entity of gestational hypertension disorder. We compared the impact of thrombophilia and its associated complications in patients with gestational hypertension with moderate and severe preeclampsia. Thus, we found obesity, thrombophilia, and underlying cardiac pathology to be significant risk factors for severe preeclampsia. Regarding the comparative analysis of the risk factors and complications associated with patients with mild preeclampsia compared with those with severe preeclampsia, the presence in severe preeclampsia of thrombophilia, endocrine, liver, and cardiac pathology was higher and, a higher rate of complications was observed; complications included fetal death, intrauterine growth restriction (IUGR), prematurity, fetal arrhythmia with acute fetal distress, HELLP syndrome, and placental abruption. Thrombophilia has a significant effect on the development of severe preeclampsia, and oligohydramnios as specific complication of mild preeclampsia. Factors indicating an increased risk of progression from mild preeclampsia to severe preeclampsia are in addition to inherited thrombophilia the underlying pathologies, namely cardiac, hepatic, and endocrine factors.
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Spandidos Publications style
Bohiltea RE, Cirstoiu MM, Turcan N, Stoian AP, Zugravu C, Munteanu O, Arsene LV, Oana B, Neacsu A, Furtunescu F, Furtunescu F, et al: Inherited thrombophilia is significantly associated with severe preeclampsia. Exp Ther Med 21: 261, 2021.
APA
Bohiltea, R.E., Cirstoiu, M.M., Turcan, N., Stoian, A.P., Zugravu, C., Munteanu, O. ... Furtunescu, F. (2021). Inherited thrombophilia is significantly associated with severe preeclampsia. Experimental and Therapeutic Medicine, 21, 261. https://doi.org/10.3892/etm.2021.9691
MLA
Bohiltea, R. E., Cirstoiu, M. M., Turcan, N., Stoian, A. P., Zugravu, C., Munteanu, O., Arsene, L. V., Oana, B., Neacsu, A., Furtunescu, F."Inherited thrombophilia is significantly associated with severe preeclampsia". Experimental and Therapeutic Medicine 21.3 (2021): 261.
Chicago
Bohiltea, R. E., Cirstoiu, M. M., Turcan, N., Stoian, A. P., Zugravu, C., Munteanu, O., Arsene, L. V., Oana, B., Neacsu, A., Furtunescu, F."Inherited thrombophilia is significantly associated with severe preeclampsia". Experimental and Therapeutic Medicine 21, no. 3 (2021): 261. https://doi.org/10.3892/etm.2021.9691
Copy and paste a formatted citation
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Spandidos Publications style
Bohiltea RE, Cirstoiu MM, Turcan N, Stoian AP, Zugravu C, Munteanu O, Arsene LV, Oana B, Neacsu A, Furtunescu F, Furtunescu F, et al: Inherited thrombophilia is significantly associated with severe preeclampsia. Exp Ther Med 21: 261, 2021.
APA
Bohiltea, R.E., Cirstoiu, M.M., Turcan, N., Stoian, A.P., Zugravu, C., Munteanu, O. ... Furtunescu, F. (2021). Inherited thrombophilia is significantly associated with severe preeclampsia. Experimental and Therapeutic Medicine, 21, 261. https://doi.org/10.3892/etm.2021.9691
MLA
Bohiltea, R. E., Cirstoiu, M. M., Turcan, N., Stoian, A. P., Zugravu, C., Munteanu, O., Arsene, L. V., Oana, B., Neacsu, A., Furtunescu, F."Inherited thrombophilia is significantly associated with severe preeclampsia". Experimental and Therapeutic Medicine 21.3 (2021): 261.
Chicago
Bohiltea, R. E., Cirstoiu, M. M., Turcan, N., Stoian, A. P., Zugravu, C., Munteanu, O., Arsene, L. V., Oana, B., Neacsu, A., Furtunescu, F."Inherited thrombophilia is significantly associated with severe preeclampsia". Experimental and Therapeutic Medicine 21, no. 3 (2021): 261. https://doi.org/10.3892/etm.2021.9691
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