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Review Open Access

Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review)

  • Authors:
    • Elena Niculet
    • Valentin Chioncel
    • Alina M. Elisei
    • Magdalena Miulescu
    • Olimpia D. Buzia
    • Lawrence C. Nwabudike
    • Mihaela Craescu
    • Miruna Draganescu
    • Florin Bujoreanu
    • Elisabeta Marinescu
    • Manuela Arbune
    • Diana Sabina Radaschin
    • Carmen Bobeica
    • Aurel Nechita
    • Alin L. Tatu
  • View Affiliations / Copyright

    Affiliations: Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galati, Romania, Cardio‑Thoracic Department, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galati, Romania, Department of Diabetic Foot Care, ‘Prof. N. Paulescu’ National Institute of Diabetes, 011233 Bucharest, Romania, Clinical Department, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800010 Galati, Romania, Department of Dermatology, ‘Sf. Cuvioasa Parascheva’ Clinical Hospital of Infectious Diseases, 800179 Galati, Romania, Centre of Medical‑Pharmaceutical Research, ‘Dunărea de Jos’ University, 800010 Galati, Romania, Research Center in The Field of Medical and Pharmaceutical Sciences, ReFORM‑UDJ, ‘Dunărea de Jos’ University, 800010 Galati, Romania, Department of Dermato‑Venereology, Doctoral School, University of Medicine and Pharmacy ‘Gr. T. Popa’, 700115 Iași, Romania
    Copyright: © Niculet et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 263
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    Published online on: January 25, 2021
       https://doi.org/10.3892/etm.2021.9693
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Abstract

Interleukin 6 (IL‑6), a cytokine produced by various cells of the human body (macrophages, lymphocytes, astrocytes, ischemic myocytes, endothelial cells) has both pro‑inflammatory and anti‑inflammatory properties, being a key component in regulating various physiologic and pathological processes. The structure of this molecule and the receptor system it possesses are important due to the different activities that IL‑6 can exert; through trans‑signaling pro‑inflammatory activities are mediated, while through classic signaling, IL‑6 is responsible for anti‑inflammatory and regenerative activities. IL‑6 signaling is involved in coronary artery disease and the global COVID‑19 pandemic. This proatherogenic cytokine reaches elevated serum levels in the cytokine storm generated by SARS‑CoV‑2, and is also associated with smoking or obesity‑classic cardiovascular risk factors which promote inflammatory states. IL‑6 levels are proportionally correlated with dyslipidemia, hypertension and glucose dysregulation, and they are associated with poor outcomes in patients with unstable angina or acute myocardial infarction. IL‑6 targeting for treatment development (not only) in cardiovascular disease and COVID‑19 is still a matter of ongoing research, although tocilizumab has proven to be effective in reducing the proatherogenic effects of IL‑6 and is suggested to improve COVID‑19 patient survival.
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Copy and paste a formatted citation
Spandidos Publications style
Niculet E, Chioncel V, Elisei AM, Miulescu M, Buzia OD, Nwabudike LC, Craescu M, Draganescu M, Bujoreanu F, Marinescu E, Marinescu E, et al: Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review). Exp Ther Med 21: 263, 2021.
APA
Niculet, E., Chioncel, V., Elisei, A.M., Miulescu, M., Buzia, O.D., Nwabudike, L.C. ... Tatu, A.L. (2021). Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review). Experimental and Therapeutic Medicine, 21, 263. https://doi.org/10.3892/etm.2021.9693
MLA
Niculet, E., Chioncel, V., Elisei, A. M., Miulescu, M., Buzia, O. D., Nwabudike, L. C., Craescu, M., Draganescu, M., Bujoreanu, F., Marinescu, E., Arbune, M., Radaschin, D. S., Bobeica, C., Nechita, A., Tatu, A. L."Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review)". Experimental and Therapeutic Medicine 21.3 (2021): 263.
Chicago
Niculet, E., Chioncel, V., Elisei, A. M., Miulescu, M., Buzia, O. D., Nwabudike, L. C., Craescu, M., Draganescu, M., Bujoreanu, F., Marinescu, E., Arbune, M., Radaschin, D. S., Bobeica, C., Nechita, A., Tatu, A. L."Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review)". Experimental and Therapeutic Medicine 21, no. 3 (2021): 263. https://doi.org/10.3892/etm.2021.9693
Copy and paste a formatted citation
x
Spandidos Publications style
Niculet E, Chioncel V, Elisei AM, Miulescu M, Buzia OD, Nwabudike LC, Craescu M, Draganescu M, Bujoreanu F, Marinescu E, Marinescu E, et al: Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review). Exp Ther Med 21: 263, 2021.
APA
Niculet, E., Chioncel, V., Elisei, A.M., Miulescu, M., Buzia, O.D., Nwabudike, L.C. ... Tatu, A.L. (2021). Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review). Experimental and Therapeutic Medicine, 21, 263. https://doi.org/10.3892/etm.2021.9693
MLA
Niculet, E., Chioncel, V., Elisei, A. M., Miulescu, M., Buzia, O. D., Nwabudike, L. C., Craescu, M., Draganescu, M., Bujoreanu, F., Marinescu, E., Arbune, M., Radaschin, D. S., Bobeica, C., Nechita, A., Tatu, A. L."Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review)". Experimental and Therapeutic Medicine 21.3 (2021): 263.
Chicago
Niculet, E., Chioncel, V., Elisei, A. M., Miulescu, M., Buzia, O. D., Nwabudike, L. C., Craescu, M., Draganescu, M., Bujoreanu, F., Marinescu, E., Arbune, M., Radaschin, D. S., Bobeica, C., Nechita, A., Tatu, A. L."Multifactorial expression of IL‑6 with update on COVID‑19 and the therapeutic strategies of its blockade (Review)". Experimental and Therapeutic Medicine 21, no. 3 (2021): 263. https://doi.org/10.3892/etm.2021.9693
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