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Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review)

  • Authors:
    • Octavia O. Căpățînă
    • Ioana V. Micluția
    • Mihaela Fadgyas-Stănculete
  • View Affiliations / Copyright

    Affiliations: Department of Neurosciences, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
    Copyright: © Căpățînă et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 276
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    Published online on: January 25, 2021
       https://doi.org/10.3892/etm.2021.9707
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Abstract

The negative symptoms of schizophrenia are an unmet treatment target as currently approved treatments mostly control positive symptoms. The persistence of these symptoms holds back the patient's reinstatement in society, making them incapable of fulfilling their social, professional, or family roles. There is overwhelming research evidence suggesting that the negative symptoms of schizophrenia are associated with poorer functioning and lower quality of life than positive symptoms, confirming the need for developing new treatments for this particular category of symptoms. This present review aims to review clinical trials addressing novel pharmacological approaches addressing primary negative symptoms of schizophrenia. We overview both monotherapies, first‑generation and second‑generation antipsychotics, and add‑on therapies, including psychostimulants, anti‑inflammatory drugs, antidepressants, molecules targeting glutamatergic, cholinergic or serotonergic systems and hormones. Our findings suggest that the primary negative symptoms of schizophrenia may be mitigated by adjunctive therapies, and we highlight the pharmacological agents that have proven superior efficacy. Novel compounds such as cariprazine and MIN‑101, to date, show promising results, but large clinical trials are needed to test their efficacy and safety.
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Copy and paste a formatted citation
Spandidos Publications style
Căpățînă OO, Micluția IV and Fadgyas-Stănculete M: Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review). Exp Ther Med 21: 276, 2021.
APA
Căpățînă, O.O., Micluția, I.V., & Fadgyas-Stănculete, M. (2021). Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review). Experimental and Therapeutic Medicine, 21, 276. https://doi.org/10.3892/etm.2021.9707
MLA
Căpățînă, O. O., Micluția, I. V., Fadgyas-Stănculete, M."Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review)". Experimental and Therapeutic Medicine 21.3 (2021): 276.
Chicago
Căpățînă, O. O., Micluția, I. V., Fadgyas-Stănculete, M."Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review)". Experimental and Therapeutic Medicine 21, no. 3 (2021): 276. https://doi.org/10.3892/etm.2021.9707
Copy and paste a formatted citation
x
Spandidos Publications style
Căpățînă OO, Micluția IV and Fadgyas-Stănculete M: Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review). Exp Ther Med 21: 276, 2021.
APA
Căpățînă, O.O., Micluția, I.V., & Fadgyas-Stănculete, M. (2021). Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review). Experimental and Therapeutic Medicine, 21, 276. https://doi.org/10.3892/etm.2021.9707
MLA
Căpățînă, O. O., Micluția, I. V., Fadgyas-Stănculete, M."Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review)". Experimental and Therapeutic Medicine 21.3 (2021): 276.
Chicago
Căpățînă, O. O., Micluția, I. V., Fadgyas-Stănculete, M."Current perspectives in treating negative symptoms of schizophrenia: A narrative review (Review)". Experimental and Therapeutic Medicine 21, no. 3 (2021): 276. https://doi.org/10.3892/etm.2021.9707
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