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Article

Association between vascular comorbidity and glaucoma progression: A four-year observational study

  • Authors:
    • Ana Maria Dascalu
    • Daniela Stana
    • Vanesa Andrada Nicolae
    • Catalin Cirstoveanu
    • Geta Vancea
    • Dragos Serban
    • Bogdan Socea
  • View Affiliations / Copyright

    Affiliations: Faculty of Medicine, ʻCarol Davilaʼ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Ophthalmology, Emergency University Hospital Bucharest, 050098 Bucharest, Romania
  • Article Number: 283
    |
    Published online on: January 26, 2021
       https://doi.org/10.3892/etm.2021.9714
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Abstract

Glaucoma, one of the significant causes of blindness worldwide, is a chronic optic neuropathy, characterized by progressive loss of retinal ganglion cells and specific perimetric defects. This study aimed to assess the association between the risk of glaucoma progression and different systemic vascular abnormalities. A 4-year prospective study was carried out on 204 patients diagnosed with open-angle glaucoma. Associated systemic vascular pathology was documented in 102 cases. Progression was encountered in 57 (55.9%) patients with vascular comorbidities and only in 10 (9.8%) patients with no associated vascular diseases (OR 13.81, P<0.01). The vascular risk factors associated with glaucoma progression in the study group were diastolic hypotension (OR 5.444, P=0.027), ischemic cardiac disease (OR 5.826; P<0.01), peripheral vasospasm (OR 3.108, P=0.042) and arterial hypertension (OR 2.593, P=0.05). Diabetes was not significantly correlated with progression in the study group, but only patients without diabetic retinopathy were included. This study highlights that systemic comorbidities associated with endothelial lesions, atherosclerosis and hypoperfusion can lead to damage to the retinal nerve fiber layer and the underlying conjunctive tissue.
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Copy and paste a formatted citation
Spandidos Publications style
Dascalu A, Stana D, Nicolae V, Cirstoveanu C, Vancea G, Serban D and Socea B: Association between vascular comorbidity and glaucoma progression: A four-year observational study. Exp Ther Med 21: 283, 2021.
APA
Dascalu, A., Stana, D., Nicolae, V., Cirstoveanu, C., Vancea, G., Serban, D., & Socea, B. (2021). Association between vascular comorbidity and glaucoma progression: A four-year observational study. Experimental and Therapeutic Medicine, 21, 283. https://doi.org/10.3892/etm.2021.9714
MLA
Dascalu, A., Stana, D., Nicolae, V., Cirstoveanu, C., Vancea, G., Serban, D., Socea, B."Association between vascular comorbidity and glaucoma progression: A four-year observational study". Experimental and Therapeutic Medicine 21.3 (2021): 283.
Chicago
Dascalu, A., Stana, D., Nicolae, V., Cirstoveanu, C., Vancea, G., Serban, D., Socea, B."Association between vascular comorbidity and glaucoma progression: A four-year observational study". Experimental and Therapeutic Medicine 21, no. 3 (2021): 283. https://doi.org/10.3892/etm.2021.9714
Copy and paste a formatted citation
x
Spandidos Publications style
Dascalu A, Stana D, Nicolae V, Cirstoveanu C, Vancea G, Serban D and Socea B: Association between vascular comorbidity and glaucoma progression: A four-year observational study. Exp Ther Med 21: 283, 2021.
APA
Dascalu, A., Stana, D., Nicolae, V., Cirstoveanu, C., Vancea, G., Serban, D., & Socea, B. (2021). Association between vascular comorbidity and glaucoma progression: A four-year observational study. Experimental and Therapeutic Medicine, 21, 283. https://doi.org/10.3892/etm.2021.9714
MLA
Dascalu, A., Stana, D., Nicolae, V., Cirstoveanu, C., Vancea, G., Serban, D., Socea, B."Association between vascular comorbidity and glaucoma progression: A four-year observational study". Experimental and Therapeutic Medicine 21.3 (2021): 283.
Chicago
Dascalu, A., Stana, D., Nicolae, V., Cirstoveanu, C., Vancea, G., Serban, D., Socea, B."Association between vascular comorbidity and glaucoma progression: A four-year observational study". Experimental and Therapeutic Medicine 21, no. 3 (2021): 283. https://doi.org/10.3892/etm.2021.9714
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