Correlations of sialic acid with glycated hemoglobin A1c and glycemia in postmenopausal women with type‑2 diabetes mellitus

Olaru,Octavian Gabriel; Constantin,Gianina Ioana; Pena,Catalina Monica

doi:10.3892/etm.2021.9717

Correlations of sialic acid with glycated hemoglobin A1c and glycemia in postmenopausal women with type‑2 diabetes mellitus

Authors:
- Octavian Gabriel Olaru
- Gianina Ioana Constantin
- Catalina Monica Pena
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Affiliations: Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 040292 Bucharest, Romania, Department of Biology of Aging Research, ‘Ana Aslan’ National Institute of Gerontology and Geriatrics, 011241 Bucharest, Romania
Published online on: January 26, 2021 https://doi.org/10.3892/etm.2021.9717
Article Number: 286
Copyright: © Olaru et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

For women in the postmenopausal period, age‑related changes in the hormonal status are associated with a higher risk for type‑2 diabetes and its complications. The tissue injury caused by diabetic vascular complications can induce a release of sialic acid (SA) into the general circulation leading to increased levels. The present study is a cross‑sectional single center study of 77 women in the postmenopausal period. The subjects selected for the study were divided into two groups: i) The control group, which included postmenopausal women without type‑2 diabetes mellitus (n=27); and ii) a group of postmenopausal women diagnosed with type‑2 diabetes (n=50). By analyzing how the serum values of SA were correlated with glycemia and glycated hemoglobin in the subjects with diabetes, it was determined that both parameters exhibited a strong positive correlation (P<0.0001) in the group with type‑2 diabetes. Therefore, SA may be considered as a potential marker for the screening, diagnosis or prognosis of type‑2 diabetes for postmenopausal women.

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