Hesperetin attenuates silica‑induced lung injury by reducing oxidative damage and inflammatory response

Li,Shuxian; Shao,Linlin; Fang,Jinguo; Zhang,Juan; Chen,Yanqin; Yeo,Abrey J.; Lavin,Martin F.; Yu,Gongchang; Shao,Hua

doi:10.3892/etm.2021.9728

Hesperetin attenuates silica‑induced lung injury by reducing oxidative damage and inflammatory response

Authors:
- Shuxian Li
- Linlin Shao
- Jinguo Fang
- Juan Zhang
- Yanqin Chen
- Abrey J. Yeo
- Martin F. Lavin
- Gongchang Yu
- Hua Shao
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Affiliations: Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250062, P.R. China, Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China, Primary Health Department, Linqing Health Bureau, Linqing, Shandong 252600, P.R. China, Centre for Clinical Research, The University of Queensland, Brisbane, Queensland 4072, Australia
Published online on: January 28, 2021 https://doi.org/10.3892/etm.2021.9728
Article Number: 297
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Oxidative stress and the inflammatory response are two important mechanisms of silica‑induced lung injury. Hesperetin (HSP) is a natural flavonoid compound that is found in citrus fruits and has been indicated to exhibit strong antioxidant and anti‑inflammatory properties. The current study evaluated the protective effect of HSP on lung injury in rats exposed to silica. The results indicated that the degree of alveolitis and pulmonary fibrosis in the HSP‑treated group was significantly decreased compared with the silica model group. The content of hydroxyproline (HYP) was also revealed to decrease overall in the HSP treated group compared with the silica model group, indicating that the degree of pulmonary fibrosis was decreased compared with the silica model group. The present study also demonstrated that HSP reduced oxidation levels of malondialdehyde (MDA) and increased the activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH‑PX). Total antioxidant capacity (T‑AOC) was also increased following HSP treatment, indicating that HSP can alleviate oxidative stress in the lung tissue of silica‑exposed rats. In addition, HSP was revealed to inhibit the synthesis and secretion of fibrogenic factor TGF‑β1, reduce the production of pro‑inflammatory cytokines IL‑1β, IL‑4, TNF‑α and increase the levels of anti‑inflammatory factors IFN‑γ and IL‑10. The current study demonstrated that HSP can effectively attenuate silica‑induced lung injury by reducing oxidative damage and the inflammatory response.

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