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Article Open Access

Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture

  • Authors:
    • Jingrong Liang
    • Jiaojuan Wu
    • Xudong Zhang
    • Xiaomin Hao
    • Tianxiao Zeng
    • Jiao Sun
    • Zhi Ji
    • Kibeum Park
    • Kaimin Li
    • Qingguo Liu
  • View Affiliations / Copyright

    Affiliations: School of Acupuncture‑Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, P.R. China, Shenzhen New Element Clinic, Shenzhen Bay Ecological Science and Technology Park, Shenzhen, Guangdong 518000, P.R. China, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 381
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    Published online on: February 19, 2021
       https://doi.org/10.3892/etm.2021.9812
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Abstract

Hypertension is one of the primary risk factors for cardiovascular diseases. Numerous proteins serve a critical role in hypertension. Acupuncture has been widely used as a treatment for hypertension in China. The results of the current study suggested that electroacupuncture (EA), twirling reinforcing manipulation (TRFM) and twirling reducing manipulation (TRDM) may be useful in the treatment of hypertension. Additionally, proteome analysis of spontaneously hypertensive rats treated with EA, TRFM and TRDM was performed. There were 117 (EA group), 61 (TRFM group) and 86 (TRDM group) differentially expressed proteins (DEPs) identified in the respective experimental groups compared with the model group. Moreover, parallel reaction monitoring assays were used to validate the reliability of the DEPs. The majority of the results were consistent with previous proteomics results, in particular that for expression of neudesin neurotrophic factor (NENF). NENF may potentially represent an antihypertensive drug target.
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Copy and paste a formatted citation
Spandidos Publications style
Liang J, Wu J, Zhang X, Hao X, Zeng T, Sun J, Ji Z, Park K, Li K, Liu Q, Liu Q, et al: Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture. Exp Ther Med 21: 381, 2021.
APA
Liang, J., Wu, J., Zhang, X., Hao, X., Zeng, T., Sun, J. ... Liu, Q. (2021). Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture. Experimental and Therapeutic Medicine, 21, 381. https://doi.org/10.3892/etm.2021.9812
MLA
Liang, J., Wu, J., Zhang, X., Hao, X., Zeng, T., Sun, J., Ji, Z., Park, K., Li, K., Liu, Q."Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture". Experimental and Therapeutic Medicine 21.4 (2021): 381.
Chicago
Liang, J., Wu, J., Zhang, X., Hao, X., Zeng, T., Sun, J., Ji, Z., Park, K., Li, K., Liu, Q."Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture". Experimental and Therapeutic Medicine 21, no. 4 (2021): 381. https://doi.org/10.3892/etm.2021.9812
Copy and paste a formatted citation
x
Spandidos Publications style
Liang J, Wu J, Zhang X, Hao X, Zeng T, Sun J, Ji Z, Park K, Li K, Liu Q, Liu Q, et al: Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture. Exp Ther Med 21: 381, 2021.
APA
Liang, J., Wu, J., Zhang, X., Hao, X., Zeng, T., Sun, J. ... Liu, Q. (2021). Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture. Experimental and Therapeutic Medicine, 21, 381. https://doi.org/10.3892/etm.2021.9812
MLA
Liang, J., Wu, J., Zhang, X., Hao, X., Zeng, T., Sun, J., Ji, Z., Park, K., Li, K., Liu, Q."Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture". Experimental and Therapeutic Medicine 21.4 (2021): 381.
Chicago
Liang, J., Wu, J., Zhang, X., Hao, X., Zeng, T., Sun, J., Ji, Z., Park, K., Li, K., Liu, Q."Proteomics analysis of the hypothalamus in spontaneously hypertensive rats treated with twirling reinforcing manipulation, twirling reducing manipulation or electroacupuncture". Experimental and Therapeutic Medicine 21, no. 4 (2021): 381. https://doi.org/10.3892/etm.2021.9812
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