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Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice

  • Authors:
    • Huijiao Lin
    • Xinyun Zhang
    • Jiawei Liu
    • Liwei Yuan
    • Jiale Liu
    • Chunmei Wang
    • Jinghui Sun
    • Jianguang Chen
    • Shu Jing
    • He Li
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, College of Pharmacy, Beihua University, Jilin, Jilin 132013, P.R. China, Neurology Department, Jilin City Central Hospital, Jilin, Jilin 132011, P.R. China, General Surgery Department, Affiliated Hospital of Beihua University, Jilin, Jilin 132011, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 385
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    Published online on: February 23, 2021
       https://doi.org/10.3892/etm.2021.9816
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Abstract

Chronic fatigue is frequently accompanied by decreased learning and memory capabilities. Schizantherin A (SCA) is one of the main active monomer components in Schisandra chinensis lignans. In the present study, a chronic fatigue mouse model was established using the exhausted swimming approach to investigate the effects of SCA on learning and memory and its associated mechanism of action. Learning and memory abilities were tested by step through tests and water maze methods. Levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) and malondialdehyde (MDA) in hippocampal tissue were measured by corresponding assays. The effect of SCA on the expression of kelch‑like ECH‑associated protein 1 (Keap1), nuclear factor erythroid 2‑related factor 2 (Nrf2), heme oxygenase‑1 (HO‑1), Bcl2, Bax and cleaved caspase‑3 were determined by western blot. The present results showed that SCA can improve the learning and memory capabilities of chronic fatigue mice. SCA was found to increase the activities of SOD and CAT in addition to increasing the levels of GSH but reduced the levels of MDA in hippocampus tissues. Furthermore, SCA treatment downregulated the protein expression levels of Keap1, Bax and cleaved caspase‑3 and upregulated the protein expression levels of Nrf2, HO1 and Bcl2 in the hippocampus. These results suggested that modulations in the Nrf2‑Keap1‑antioxidant response element pathway, anti‑oxidative and anti‑apoptosis effects are the causes underlying the improvements from SCA treatment on the learning and memory abilities of chronic fatigue mice.
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1 

Feng S, Liu W, Zuo S, Xie T, Deng H, Zhang Q and Zhong B: Impaired function of the intestinal barrier in a novel sub-health rat model. Mol Med Rep. 13:3459–3465. 2016.PubMed/NCBI View Article : Google Scholar

2 

Bi JL, Chen J, Sun XM, Nie XL, Liu YY, Luo R and Zhao XS: The development and evaluation of a sub-health self-rating scale for university students in China. BMC Public Health. 19(330)2019.PubMed/NCBI View Article : Google Scholar

3 

Xu X, Zeng Q, Ding H, Feng L and Deng L: Correlation between women's sub-health and reproductive diseases with pregnancies and labors. J Tradit Chin Med. 34:465–469. 2014.PubMed/NCBI View Article : Google Scholar

4 

Lenaert B, Boddez Y, Vlaeyen JWS and Caroline MH: Learning to feel tired: A learning trajectory towards chronic fatigue. Behav Res Ther. 100:54–66. 2018.PubMed/NCBI View Article : Google Scholar

5 

Zhao R, Hao W, Ma B and Chen Z: Improvement effect of Lycium barbarum polysaccharide on sub-health mice. Iran J Basic Med Sci. 18:1245–1252. 2015.PubMed/NCBI

6 

Lamou B, Taiwe GS, Hamadou A, Abene Houlray J, Atour MM and Tan PV: Antioxidant and antifatigue properties of the aqueous extract of Moringa oleifera in rats subjected to forced swimming endurance test. Oxid Med Cell Longev. 2016(3517824)2016.PubMed/NCBI View Article : Google Scholar

7 

Duan FF, Guo Y, Li JW and Yuan K: Antifatigue effect of luteolin-6-C-neohesperidoside on oxidative stress injury induced by forced swimming of rats through modulation of Nrf2/ARE signaling pathways. Oxid Med Cell Longev. 2017(3159358)2017.PubMed/NCBI View Article : Google Scholar

8 

Hsiao CY, Hsu YJ, Tung YT, Lee MC, Huang CC and Hsieh CC: Effects of Antrodia camphorata and Panax ginseng supplementation on anti-fatigue properties in mice. J Vet Med Sci. 80:284–291. 2018.PubMed/NCBI View Article : Google Scholar

9 

Liu XL, Zhu CC, Qiao DC, Hou LJ and Kang DF: Effect of exercise-induced fatigue on rat learning and memory ability and expressions of CaN in the brain. Energy Procedia. 1:248–251. 2011.

10 

van't Leven M, Zielhuis GA, van der Meer JW, Verbeek AL and Bleijenberg G: Fatigue and chronic fatigue syndrome-like complaints in the general population. Eur J Public Health. 20:251–257. 2010.PubMed/NCBI View Article : Google Scholar

11 

Qi Y, Cheng X, Jing H, Yan T, Xiao F, Wu B, Bi K and Jia Y: Effect of Alpinia oxyphylla-Schisandra chinensis herb pair on inflammation and apoptosis in Alzheimer' s disease mice model. J Ethnopharmacol. 237:28–38. 2019.PubMed/NCBI View Article : Google Scholar

12 

Gao Y, Wu S, Cong R, Xiao J and Ma F: Characterization of lignans in Schisandra chinensis oil with a single analysis process by UPLC-Q/TOF-MS. Chem Phys Lipids. 218:158–167. 2019.PubMed/NCBI View Article : Google Scholar

13 

Wang X, Yu J, Li W, Wang C, Li H, Ju W, Chen J and Sun J: Characteristics and antioxidant activity of lignans in Schisandra chinensis and Schisandra sphenanthera from different locations. Chem Biodivers. 15(e1800030)2018.PubMed/NCBI View Article : Google Scholar

14 

Zhang XY, Lin HJ, Li X, Jing S, Sun W, Jiang WH, Wang CM, Sun JH, Li H and Chen JG: Schisantherin A improves fatigue of mice by regulating the antioxidant pathway of liver Nrf2/ARE. Food Sci. 41:1–10. 2020.

15 

Liu C, Sun W, Li N, Gao J, Yu C, Wang C, Sun J, Jing S, Chen J and Li H: Schisantherin A improves learning and memory of mice with D-galactose-induced learning and memory impairment through its antioxidation and regulation of p19/p53/p21/Cyclin D1/CDK4/RB gene expressions. J Med Food. 21:678–688. 2018.PubMed/NCBI View Article : Google Scholar

16 

Cheluvappa R, Scowen P and Eri R: Ethics of animal research in human disease remediation, its institutional teaching; and alternatives to animal experimentation. Pharmacol Res Perspect. 5(e00332)2017.PubMed/NCBI View Article : Google Scholar

17 

Smith AJ, Clutton RE, Lilley E, Hansen KEA and Brattelid T: PREPARE: Guidelines for planning animal research and testing. Lab Anim. 52:135–141. 2018.PubMed/NCBI View Article : Google Scholar

18 

Yeh TS, Chuang HL, Huang WC, Chen YM, Huang CC and Hsu MC: Astragalus membranaceus improves exercise performance and ameliorates exercise-induced fatigue in trained mice. Molecules. 19:2793–2807. 2014.PubMed/NCBI View Article : Google Scholar

19 

Falavigna G, Alves de Araújo J, Rogero MM, Pires IS, Pedrosa RG, Martins E Jr, Alves de Castro I and Tirapegui J: Effects of diets supplemented with branched-chain amino acids on the performance and fatigue mechanisms of rats submitted to prolonged physical exercise. Nutrients. 4:1767–1780. 2012.PubMed/NCBI View Article : Google Scholar

20 

Liu C, Wen Y, Huang H, Lin W, Huang M, Lin R and Ma Y: Over-expression of 5-HT6 receptor and activated Jab-1/p-c-Jun play important roles in pilocarpine-induced seizures and learning-memory impairment. J Mol Neurosci. 67:388–399. 2019.PubMed/NCBI View Article : Google Scholar

21 

Zhou J, Liu X, Chen T, Cheng G and Cai S: Preventive effect of ethanol extract from Chinese sumac fruits against tetrachloromethane-induced liver fibrosis in mice. Food Funct. 11:7061–7072. 2020.PubMed/NCBI View Article : Google Scholar

22 

Huang CC, Hsu MC, Huang WC, Yang HR and Hou CC: Triterpenoid-rich extract from Antrodia camphorata improves physical fatigue and exercise performance in mice. Evid Based Complement Alternat Med. 2012(364741)2012.PubMed/NCBI View Article : Google Scholar

23 

Sowndhararajan K, Deepa P, Kim M, Park SJ and Kim S: An overview of neuroprotective and cognitive enhancement properties of lignans from. Schisandra chinensis. Biomed Pharmacother. 97:958–968. 2018.PubMed/NCBI View Article : Google Scholar

24 

Rasouli O, Gotaas ME, Stensdotter AK, Skovlund E, Landrø NI, Dåstøl P and Fors EA: Neuropsychological dysfunction in chronic fatigue syndrome and the relation between objective and subjective findings. Neuropsychology. 33:658–669. 2019.PubMed/NCBI View Article : Google Scholar

25 

Fan XL, Li F and Song YH: Effect of sihui mixture on the learning and memory ability, mRNA expressions of hippocampus NMDA subunit NR2A and NR2B, and EphB2 receptor in fatigue rats. Zhongguo Zhong Xi Yi Jie He Za Zhi. 31:512–516. 2011.PubMed/NCBI(In Chinese).

26 

Ramos D, Martins EG, Viana-Gomes D, Casimiro-Lopes G and Salerno VP: Biomarkers of oxidative stress and tissue damage released by muscle and liver after a single bout of swimming exercise. Appl Physiol Nutr Metab. 38:507–511. 2013.PubMed/NCBI View Article : Google Scholar

27 

Baghcheghi Y, Salmani H, Beheshti F, Shafei MN, Sadeghnia HR and Soukhtanloo M: Effects of PPAR-γ agonist, pioglitazone on brain tissues oxidative damage and learning and memory impairment in juvenile hypothyroid rats. Int J Neurosci. 129:1024–1038. 2019.PubMed/NCBI View Article : Google Scholar

28 

Halder S, Kar R, Galav V, Mehta AK, Bhattacharya SK, Mediratta PK and Banerjee BD: Cadmium exposure during lactation causes learning and memory-impairment in F1 generation mice: Amelioration by quercetin. Drug Chem Toxicol. 39:272–278. 2016.PubMed/NCBI View Article : Google Scholar

29 

Haddadi M, Jahromi SR, Sagar BK, Patil RK, Shivanandappa T and Ramesh SR: Brain aging memory impairment and oxidative stress: A study in Drosophila melanogaster. Behav Brain Res. 259:60–69. 2014.PubMed/NCBI View Article : Google Scholar

30 

Schurman LD, Carper MC, Moncayo LV, Ogasawara D, Richardson K, Yu L, Liu X, Poklis JL, Liu QS, Cravatt BF and Lichtman AH: Diacylglycerol lipase-alpha regulates hippocampal-dependent learning and memory processes in mice. J Neurosci. 39:5949–5965. 2019.PubMed/NCBI View Article : Google Scholar

31 

Tu WJ, Wang H, Li S, Liu Q and Sha H: The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases. Aging Dis. 10:637–651. 2019.PubMed/NCBI View Article : Google Scholar

32 

Chen K, You J, Tang Y, Zhou Y, Liu P, Zou D, Zhou Q, Zhang T, Zhu J and Mi M: Supplementation of superfine powder prepared from Chaenomeles speciosa fruit increases endurance capacity in rats via antioxidant and Nrf2/ARE signaling pathway. Evid Based Complement Alternat Med. 2014(976438)2014.PubMed/NCBI View Article : Google Scholar

33 

Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H and Yamamoto M: Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Mol Cell Biol. 30:3016–3026. 2010.PubMed/NCBI View Article : Google Scholar

34 

Kopacz A, Kloska D, Forman HJ, Jozkowicz A and Grochot-Przeczek A: Beyond repression of Nrf2: An update on Keap1. Free Radic Biol Med. 157:63–74. 2020.PubMed/NCBI View Article : Google Scholar

35 

Baird L and Yamamoto M: The molecular mechanisms regulating the KEAP1-NRF2 pathway. Mol Cell Biol. 40:e00099–20. 2020.PubMed/NCBI View Article : Google Scholar

36 

Zhong L, Zhao L, Yang F, Yang W, Sun Y and Hu Q: Evaluation of anti-fatigue property of the extruded product of cereal grains mixed with cordyceps militaris on mice. J Int Soc Sports Nutr. 14(15)2017.PubMed/NCBI View Article : Google Scholar

37 

Surhio MM, Wang YF, Fang S, Li J and Ye M: Anti-fatigue activity of a lachnum polysaccharide and its carboxymethylated derivative in mice. Bioorg Med Chem Lett. 27:4777–4780. 2017.PubMed/NCBI View Article : Google Scholar

38 

Wang K, Chen Z, Huang J, Huang L, Luo N, Liang X, Liang M and Xie W: Naringenin prevents ischaemic stroke damage via anti-apoptotic and anti-oxidant effects. Clin Exp Pharmacol Physiol. 44:862–871. 2017.PubMed/NCBI View Article : Google Scholar

39 

Jiang XM, Hu JH, Wang LL, Ma C, Wang X and Liu XL: Ulinastatin alleviates neurological deficiencies evoked by transient cerebral ischemia via improving autophagy, Nrf-2-ARE and apoptosis signals in hippocampus. Physiol Res. 67:637–646. 2018.PubMed/NCBI View Article : Google Scholar

40 

Yoo ES, Choo GS, Kim SH, Woo JS, Kim HJ, Park YS, Kim BS, Kim SK, Park BK, Cho SD, et al: Antitumor and apoptosis-inducing effects of piperine on human melanoma cells. Anticancer Res. 39:1883–1892. 2019.PubMed/NCBI View Article : Google Scholar

41 

Niture SK and Jaiswal AK: Nrf2 up-regulates anti-apoptotic protein Bcl-2 and prevents cellular apoptosis. J Biol Chem. 287:9873–9886. 2012.PubMed/NCBI View Article : Google Scholar

42 

Zhang J, Su L, Ye Q, Zhang S, Kung H, Jiang F, Jiang G, Miao J and Zhao B: Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells. Oncotarget. 8:7625–7636. 2017.PubMed/NCBI View Article : Google Scholar

43 

Ye J, Jiang R, Cui M, Zhu B, Sun L, Wang Y, Zohaib A, Dong Q, Ruan X, Song Y, et al: Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. J Infect Dis. 210:875–889. 2014.PubMed/NCBI View Article : Google Scholar

44 

Gu Y, Yang Y, Cao X, Zhao Y, Gao X, Sun C, Zhang F, Yuan Y, Xu Y, Zhang J, et al: Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum. J Cell Biochem. 120:16075–16087. 2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Lin H, Zhang X, Liu J, Yuan L, Liu J, Wang C, Sun J, Chen J, Jing S, Li H, Li H, et al: Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice. Exp Ther Med 21: 385, 2021.
APA
Lin, H., Zhang, X., Liu, J., Yuan, L., Liu, J., Wang, C. ... Li, H. (2021). Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice. Experimental and Therapeutic Medicine, 21, 385. https://doi.org/10.3892/etm.2021.9816
MLA
Lin, H., Zhang, X., Liu, J., Yuan, L., Liu, J., Wang, C., Sun, J., Chen, J., Jing, S., Li, H."Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice". Experimental and Therapeutic Medicine 21.4 (2021): 385.
Chicago
Lin, H., Zhang, X., Liu, J., Yuan, L., Liu, J., Wang, C., Sun, J., Chen, J., Jing, S., Li, H."Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice". Experimental and Therapeutic Medicine 21, no. 4 (2021): 385. https://doi.org/10.3892/etm.2021.9816
Copy and paste a formatted citation
x
Spandidos Publications style
Lin H, Zhang X, Liu J, Yuan L, Liu J, Wang C, Sun J, Chen J, Jing S, Li H, Li H, et al: Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice. Exp Ther Med 21: 385, 2021.
APA
Lin, H., Zhang, X., Liu, J., Yuan, L., Liu, J., Wang, C. ... Li, H. (2021). Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice. Experimental and Therapeutic Medicine, 21, 385. https://doi.org/10.3892/etm.2021.9816
MLA
Lin, H., Zhang, X., Liu, J., Yuan, L., Liu, J., Wang, C., Sun, J., Chen, J., Jing, S., Li, H."Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice". Experimental and Therapeutic Medicine 21.4 (2021): 385.
Chicago
Lin, H., Zhang, X., Liu, J., Yuan, L., Liu, J., Wang, C., Sun, J., Chen, J., Jing, S., Li, H."Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice". Experimental and Therapeutic Medicine 21, no. 4 (2021): 385. https://doi.org/10.3892/etm.2021.9816
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