Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis

  • Authors:
    • Li Wang
    • Qi Ji
    • Xiaoyan Hu
  • View Affiliations / Copyright

    Affiliations: Departments of Operating Room, The First People's Hospital of Lianyungang City, Lianyungang, Jiangsu 222002, P.R. China, Departments of Tongguan Operating Room, The First People's Hospital of Lianyungang City, Lianyungang, Jiangsu 222002, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 416
    |
    Published online on: February 25, 2021
       https://doi.org/10.3892/etm.2021.9860
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The purpose of the present study was to provide a systematic literature review and pool evidence on the efficacy of mupirocin‑based decolonization protocol in reducing surgical‑site infections (SSIs) in patients undergoing cardiothoracic (CT) surgery based on their Staphylococcus (S.) aureus carrier state. The PubMed, Embase, Ovid, BioMed Central, Cochrane Central Register of Controlled Trials and Google Scholar databases were searched for studies comparing mupirocin‑based decolonization with controls for reducing SSIs in patients following CT surgery. Studies were grouped based on the targeted population of intervention, i.e. carriers or all patients. A total of 17 studies were included. Of these, 8 studies used targeted mupirocin‑based decolonization, while universal decolonization was performed in 9 studies. The results were conflicting for studies performing targeted decolonization and it was not possible to perform a meta‑analysis due to non‑homogenous studies. Pooled analysis of 34,859 patients indicated that universal mupirocin‑based decolonization significantly reduced the risk of all SSIs [risk ratio (RR): 0.54; 95% CI: 0.40,0.75; I2=73.35%]. The intervention significantly reduced the risk of superficial SSIs (RR: 0.37; 95% CI: 0.25,0.55; I2=0%) but not of deep SSIs (RR: 0.45; 95% CI: 0.19,1.09; I2=80.67%). The results indicated a significantly reduced risk of S. aureus SSIs (SA‑SSIs) with mupirocin‑based decolonization (RR: 0.44; 95% CI: 0.32,0.61; I2=0%) but not for methicillin‑resistant S. aureus (MRSA‑SSIs; RR: 0.25; 95% CI: 0.05,1.28; I2=79.07%). Evidence on the role of targeted mupirocin‑based decolonization to reduce SSIs after CT surgery was non‑coherent and inconclusive. Analysis of low‑quality retrospective studies suggested that universal mupirocin‑based decolonization may reduce all SSIs, superficial SSIs and SA‑SSIs, but not deep SSIs or MRSA‑SSIs in patients after CT surgery.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Loop FD, Lytle BW, Cosgrove DM, Mahfood S, McHenry MC, Goormastic M, Stewart RW, Golding LA and Taylor PC: J Maxwell Chamberlain memorial paper. Sternal wound complications after isolated coronary artery bypass grafting: Early and late mortality, morbidity, and cost of care. Ann Thorac Surg. 49:179–186; discussion 186-7. 1990.PubMed/NCBI View Article : Google Scholar

2 

Lepelletier D, Perron S, Bizouarn P, Caillon J, Drugeon H, Michaud JL and Duveau D: Surgical-site infection after cardiac surgery: Incidence, microbiology, and risk factors. Infect Control Hosp Epidemiol. 26:466–472. 2005.PubMed/NCBI View Article : Google Scholar

3 

Saadatian-Elahi M, Teyssou R and Vanhems P: Staphylococcus aureus, the major pathogen in orthopaedic and cardiac surgical site infections: A literature review. Int J Surg. 6:238–245. 2008.PubMed/NCBI View Article : Google Scholar

4 

Abboud CS, Wey SB and Baltar VT: Risk factors for mediastinitis after cardiac surgery. Ann Thorac Surg. 77:676–683. 2004.PubMed/NCBI View Article : Google Scholar

5 

Grossi EA, Culliford AT, Krieger KH, Kloth D, Press R, Baumann FG and Spencer FC: A survey of 77 major infectious complications of median sternotomy: A review of 7,949 consecutive operative procedures. Ann Thorac Surg. 40:214–223. 1985.PubMed/NCBI View Article : Google Scholar

6 

Filsoufi F, Castillo JG, Rahmanian PB, Broumand SR, Silvay G, Carpentier A and Adams DH: Epidemiology of deep sternal wound infection in cardiac surgery. J Cardiothorac Vasc Anesth. 23:488–494. 2009.PubMed/NCBI View Article : Google Scholar

7 

Verhoeven PO, Gagnaire J, Botelho-Nevers E, Grattard F, Carricajo A, Lucht F, Pozzetto B and Berthelot P: Detection and clinical relevance of Staphylococcus aureus nasal carriage: An update. Expert Rev Anti Infect Ther. 12:75–89. 2014.PubMed/NCBI View Article : Google Scholar

8 

Gagnaire J, Verhoeven PO, Grattard F, Rigaill J, Lucht F, Pozzetto B, Berthelot P and Botelho-Nevers E: Epidemiology and clinical relevance of Staphylococcus aureus intestinal carriage: A systematic review and meta-analysis. Expert Rev Anti Infect Ther. 15:767–785. 2017.PubMed/NCBI View Article : Google Scholar

9 

Katayanagi T: Nasal methicillin-resistant S aureus is a major risk for mediastinitis in pediatric cardiac surgery. Ann Thorac Cardiovasc Surg. 21:37–44. 2015.PubMed/NCBI View Article : Google Scholar

10 

van Rijen M, Bonten M, Wenzel R and Kluytmans J: Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers. Cochrane Database Syst Rev. 4(CD006216)2008.PubMed/NCBI View Article : Google Scholar

11 

Langenberg JCM, Kluytmans JAJW, Mulder PGH, Romme J, Ho GH and Van Der Laan L: Peri-Operative nasal eradication therapy prevents staphylococcus aureus surgical site infections in aortoiliac surgery. Surg Infect (Larchmt). 19:510–515. 2018.PubMed/NCBI View Article : Google Scholar

12 

Bode LG, Kluytmans JA, Wertheim HF, Bogaers D, Vandenbroucke-Grauls CM, Roosendaal R, Troelstra A, Box AT, Voss A, van der Tweel I, et al: Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med. 362:9–17. 2010.PubMed/NCBI View Article : Google Scholar

13 

Konvalinka A, Errett L and Fong IW: Impact of treating Staphylococcus aureus nasal carriers on wound infections in cardiac surgery. J Hosp Infect. 64:162–168. 2006.PubMed/NCBI View Article : Google Scholar

14 

Lemaignen A, Armand-Lefevre L, Birgand G, Mabileau G, Lolom I, Ghodbane W, Dilly MP, Nataf P and Lucet JC: Thirteen-year experience with universal Staphylococcus aureus nasal decolonization prior to cardiac surgery: A quasi-experimental study. J Hosp Infect. 100:322–328. 2018.PubMed/NCBI View Article : Google Scholar

15 

Sakr A, Brégeon F, Rolain JM and Blin O: Staphylococcus aureus nasal decolonization strategies: A review. Expert Rev Anti Infect Ther. 17:327–340. 2019.PubMed/NCBI View Article : Google Scholar

16 

Liu Z, Norman G, Iheozor-Ejiofor Z, Wong JK, Crosbie EJ and Wilson P: Nasal decontamination for the prevention of surgical site infection in Staphylococcus aureus carriers. Cochrane Database Syst Rev. 5(CD012462)2017.PubMed/NCBI View Article : Google Scholar

17 

Schweizer M, Perencevich E, McDanel J, Carson J, Formanek M, Hafner J, Braun B and Herwaldt L: Effectiveness of a bundled intervention of decolonization and prophylaxis to decrease Gram positive surgical site infections after cardiac or orthopedic surgery: Systematic review and meta-analysis. BMJ. 346(f2743)2013.PubMed/NCBI View Article : Google Scholar

18 

Ma N, Cameron A, Tivey D, Grae N, Roberts S and Morris A: Systematic review of a patient care bundle in reducing staphylococcal infections in cardiac and orthopaedic surgery. ANZ J Surg. 87:239–246. 2017.PubMed/NCBI View Article : Google Scholar

19 

Moher D, Liberati A, Tetzlaff J, Altman DG and PRISMA Group: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. BMJ. 339(b2535)2009.PubMed/NCBI View Article : Google Scholar

20 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ and Welch VA: Cochrane Handbook for Systematic Reviews of Interventions. Version 6.1 (updated September 2020). Cochrane, 2020. Available from www.training.cochrane.org/handbook.

21 

Kim SY, Park JE, Lee YJ, Seo HJ, Sheen SS, Hahn S, Jang BH and Son HJ: Testing a tool for assessing the risk of bias for nonrandomized studies showed moderate reliability and promising validity. J Clin Epidemiol. 66:408–414. 2013.PubMed/NCBI View Article : Google Scholar

22 

Wallace BC, Schmid CH, Lau J and Trikalinos TA: Meta-analyst: Software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Methodol. 9(80)2009.PubMed/NCBI View Article : Google Scholar

23 

Usry GH, Johnson L, Weems JJ Jr and Blackhurst D: Process improvement plan for the reduction of sternal surgical site infections among patients undergoing coronary artery bypass graft surgery. Am J Infect Control. 30:434–436. 2002.PubMed/NCBI View Article : Google Scholar

24 

Cimochowski GE, Harostock MD, Brown R, Bernardi M, Alonzo N and Coyle K: Intranasal mupirocin reduces sternal wound infection after open heart surgery in diabetics and nondiabetics. Ann Thorac Surg. 71:1572–1578; discussion 1578-9. 2001.PubMed/NCBI View Article : Google Scholar

25 

Coskun D and Aytac J: Decrease in Staphylococcus aureus surgical site infections following cardiovascular surgery. J Hosp Infect. 60:287–289. 2005.

26 

Martorell C, Engelman R, Corl A and Brown RB: Surgical site infections in cardiac surgery: An 11-year perspective. Am J Infect Control. 32:63–68. 2004.PubMed/NCBI View Article : Google Scholar

27 

Thompson P and Houston S: Decreasing methicillin-resistant Staphylococcus aureus surgical site infections with chlorhexidine and mupirocin. Am J Infect Control. 41:629–633. 2013.PubMed/NCBI View Article : Google Scholar

28 

Walsh EE, Greene L and Kirshner R: Sustained reduction in methicillin-resistant Staphylococcus aureus wound infections after cardiothoracic surgery. Arch Intern Med. 171:68–73. 2011.PubMed/NCBI View Article : Google Scholar

29 

Kohler P, Sommerstein R, Schönrath F, Ajdler-Schäffler E, Anagnostopoulos A, Tschirky S, Falk V, Kuster SP and Sax H: Effect of perioperative mupirocin and antiseptic body wash on infection rate and causative pathogens in patients undergoing cardiac surgery. Am J Infect Control. 43:e33–e38. 2015.PubMed/NCBI View Article : Google Scholar

30 

Nicholson MR and Huesman LA: Controlling the usage of intranasal mupirocin does impact the rate of Staphylococcus aureus deep sternal wound infections in cardiac surgery patients. Am J Infect Control. 34:44–48. 2006.PubMed/NCBI View Article : Google Scholar

31 

Shrestha NK, Banbury MK, Weber M, Cwynar RE, Lober C, Procop GW, Karafa MT and Gordon SM: Safety of targeted perioperative mupirocin treatment for preventing infections after cardiac surgery. Ann Thorac Surg. 81:2183–2188. 2006.PubMed/NCBI View Article : Google Scholar

32 

Jog S, Cunningham R, Cooper S, Wallis M, Marchbank A, Vasco-Knight P and Jenks PJ: Impact of preoperative screening for meticillin-resistant Staphylococcus aureus by real-time polymerase chain reaction in patients undergoing cardiac surgery. J Hosp Infect. 69:124–130. 2008.PubMed/NCBI View Article : Google Scholar

33 

Schweizer ML, Chiang HY, Septimus E, Moody J, Braun B, Hafner J, Ward MA, Hickok J, Perencevich EN, Diekema DJ, et al: Association of a bundled intervention with surgical site infections among patients undergoing cardiac, hip, or knee surgery. JAMA. 313:2162–2171. 2015.PubMed/NCBI View Article : Google Scholar

34 

Saraswat MK, Magruder JT, Crawford TC, Gardner JM, Duquaine D, Sussman MS, Maragakis LL and Whitman GJ: Preoperative staphylococcus aureus screening and targeted decolonization in cardiac surgery. Ann Thorac Surg. 104:1349–1356. 2017.PubMed/NCBI View Article : Google Scholar

35 

Nicolas R, Carricajo A, Morel J, Rigaill J, Grattard F, Guezzou S, Audoux E, Campisi S, Favre JP, Berthelot P, et al: Evaluation of effectiveness and compliance with the mupirocin nasal ointment part of Staphylococcus aureus decolonization in real life using UPLC-MS/MS mupirocin quantification. J Antimicrob Chemother. 75:1623–1630. 2020.PubMed/NCBI View Article : Google Scholar

36 

Kluytmans JA, Mouton JW, VandenBergh MF, Manders MJ, Maat AP, Wagenvoort JH, Michel MF and Verbrugh HA: Reduction of surgical-site infections in cardiothoracic surgery by elimination of nasal carriage of staphylococcus aureus. Infect Control Hosp Epidemiol. 17:780–785. 1996.PubMed/NCBI View Article : Google Scholar

37 

Gebreselassie HM, Lo Priore E and Marschall J: Effectiveness of meticillin-resistant Staphylococcus aureus decolonization in long-term haemodialysis patients: A systematic review and meta-analysis. J Hosp Infect. 91:250–256. 2015.PubMed/NCBI View Article : Google Scholar

38 

Nair R, Perencevich EN, Blevins AE, Goto M, Nelson RE and Schweizer ML: Clinical effectiveness of mupirocin for preventing staphylococcus aureus infections in nonsurgical settings: A meta-analysis. Clin Infect Dis. 62:618–630. 2016.PubMed/NCBI View Article : Google Scholar

39 

Wenzel RP and Edmond MB: Infection control: The case for horizontal rather than vertical interventional programs. Int J Infect Dis. 14 (Suppl 4):S3–S5. 2010.PubMed/NCBI View Article : Google Scholar

40 

Huang SS, Septimus E, Kleinman K, Moody J, Hickok J, Avery TR, Lankiewicz J, Gombosev A, Terpstra L, Hartford F, et al: Targeted versus universal decolonization to prevent ICU infection. N Engl J Med. 368:2255–2265. 2013.PubMed/NCBI View Article : Google Scholar

41 

Dadashi M, Hajikhani B, Darban-Sarokhalil D, van Belkum A and Goudarzi M: Mupirocin resistance in Staphylococcus aureus: A systematic review and meta-analysis. J Glob Antimicrob Resist. 20:238–247. 2020.PubMed/NCBI View Article : Google Scholar

42 

Hayden MK, Lolans K, Haffenreffer K, Avery TR, Kleinman K, Li H, Kaganov RE, Lankiewicz J, Moody J, Septimus E, et al: Chlorhexidine and mupirocin susceptibility of methicillin-resistant staphylococcus aureus isolates in the REDUCE-MRSA trial. J Clin Microbiol. 54:2735–2742. 2016.PubMed/NCBI View Article : Google Scholar

43 

Morgan DJ, Diekema DJ, Sepkowitz K and Perencevich EN: Adverse outcomes associated with contact precautions: A review of the literature. Am J Infect Control. 37:85–93. 2009.PubMed/NCBI View Article : Google Scholar

44 

McConeghy KW, Mikolich DJ and LaPlante KL: Agents for the decolonization of methicillin-resistant Staphylococcus aureus. Pharmacotherapy. 29:263–280. 2009.PubMed/NCBI View Article : Google Scholar

45 

Webster J and Osborne S: Preoperative bathing or showering with skin antiseptics to prevent surgical site infection. Cochrane Database Syst Rev CD004985, 2015.

46 

Franco LM, Cota GF, Pinto TS and Ercole FF: Preoperative bathing of the surgical site with chlorhexidine for infection prevention: Systematic review with meta-analysis. Am J Infect Control. 45:343–349. 2017.PubMed/NCBI View Article : Google Scholar

47 

Saleh A, Khanna A, Chagin KM, Klika AK, Johnston D and Barsoum WK: Glycopeptides versus β-lactams for the prevention of surgical site infections in cardiovascular and orthopedic surgery: A mata-analysis. Ann Surg. 261:72–80. 2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang L, Ji Q and Hu X: Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis. Exp Ther Med 21: 416, 2021.
APA
Wang, L., Ji, Q., & Hu, X. (2021). Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 21, 416. https://doi.org/10.3892/etm.2021.9860
MLA
Wang, L., Ji, Q., Hu, X."Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 21.5 (2021): 416.
Chicago
Wang, L., Ji, Q., Hu, X."Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 21, no. 5 (2021): 416. https://doi.org/10.3892/etm.2021.9860
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Ji Q and Hu X: Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis. Exp Ther Med 21: 416, 2021.
APA
Wang, L., Ji, Q., & Hu, X. (2021). Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 21, 416. https://doi.org/10.3892/etm.2021.9860
MLA
Wang, L., Ji, Q., Hu, X."Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 21.5 (2021): 416.
Chicago
Wang, L., Ji, Q., Hu, X."Role of targeted and universal mupirocin‑based decolonization for preventing surgical‑site infections in patients undergoing cardiothoracic surgery: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 21, no. 5 (2021): 416. https://doi.org/10.3892/etm.2021.9860
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team