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Article

Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts

  • Authors:
    • Parkyong Song
    • Han-Seul Jo
    • Wan-Seog Shim
    • Yang Woo Kwon
    • Sungwon Bae
    • Yonghoon Kwon
    • Bakhovuddin Azamov
    • Jin Hur
    • Dongjun Lee
    • Sung Ho Ryu
    • Jong Hyuk Yoon
  • View Affiliations / Copyright

    Affiliations: Department of Convergence Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea, Neurodegenerative Diseases Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea, Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Republic of Korea
  • Article Number: 420
    |
    Published online on: February 25, 2021
       https://doi.org/10.3892/etm.2021.9864
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Abstract

Fibrillar collagen and elastic fibers are the main components of the dermal extracellular matrix (ECM), which confers mechanical strength and resilience to the skin. In particular, type I collagen produced by fibroblasts is the most abundant collagen that determines the general strength of the ECM, thereby contributing to the prevesntion of the skin‑aging process. Although the natural anthraquinone derivative emodin (1,3,8‑trihydroxy‑6‑methylanthraquinone) exerts numerous beneficial effects, including antiviral, anticancer, anti‑inflammatory and wound‑healing effects in diverse cells, the effect of emodin on collagen expression or skin aging is not fully understood. The present study demonstrated that exposure to emodin increased type I collagen synthesis in a concentration‑ and time‑dependent manner in Hs27 human dermal fibroblasts. Subsequent experiments showed that emodin strongly increased collagen type I levels without altering cell proliferation or cellular matrix metalloproteinase‑1 (MMP‑1) expression. Additionally, it was determined that increased phosphorylation of 5' AMP‑activated protein kinase, following emodin treatment, was responsible for increased type I collagen synthesis. These findings clearly indicate that emodin plays an important role in collagen type I synthesis in dermal fibroblasts, thereby making it a potential drug candidate for treating skin aging and wrinkles.
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Copy and paste a formatted citation
Spandidos Publications style
Song P, Jo H, Shim W, Kwon YW, Bae S, Kwon Y, Azamov B, Hur J, Lee D, Ryu SH, Ryu SH, et al: Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts. Exp Ther Med 21: 420, 2021.
APA
Song, P., Jo, H., Shim, W., Kwon, Y.W., Bae, S., Kwon, Y. ... Yoon, J.H. (2021). Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts. Experimental and Therapeutic Medicine, 21, 420. https://doi.org/10.3892/etm.2021.9864
MLA
Song, P., Jo, H., Shim, W., Kwon, Y. W., Bae, S., Kwon, Y., Azamov, B., Hur, J., Lee, D., Ryu, S. H., Yoon, J. H."Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts". Experimental and Therapeutic Medicine 21.5 (2021): 420.
Chicago
Song, P., Jo, H., Shim, W., Kwon, Y. W., Bae, S., Kwon, Y., Azamov, B., Hur, J., Lee, D., Ryu, S. H., Yoon, J. H."Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts". Experimental and Therapeutic Medicine 21, no. 5 (2021): 420. https://doi.org/10.3892/etm.2021.9864
Copy and paste a formatted citation
x
Spandidos Publications style
Song P, Jo H, Shim W, Kwon YW, Bae S, Kwon Y, Azamov B, Hur J, Lee D, Ryu SH, Ryu SH, et al: Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts. Exp Ther Med 21: 420, 2021.
APA
Song, P., Jo, H., Shim, W., Kwon, Y.W., Bae, S., Kwon, Y. ... Yoon, J.H. (2021). Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts. Experimental and Therapeutic Medicine, 21, 420. https://doi.org/10.3892/etm.2021.9864
MLA
Song, P., Jo, H., Shim, W., Kwon, Y. W., Bae, S., Kwon, Y., Azamov, B., Hur, J., Lee, D., Ryu, S. H., Yoon, J. H."Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts". Experimental and Therapeutic Medicine 21.5 (2021): 420.
Chicago
Song, P., Jo, H., Shim, W., Kwon, Y. W., Bae, S., Kwon, Y., Azamov, B., Hur, J., Lee, D., Ryu, S. H., Yoon, J. H."Emodin induces collagen type I synthesis in Hs27 human dermal fibroblasts". Experimental and Therapeutic Medicine 21, no. 5 (2021): 420. https://doi.org/10.3892/etm.2021.9864
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