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Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2

  • Authors:
    • Guiyuan Yu
    • Yan Jiao
    • Jia-Jia Huang
    • Ming-Da Fan
    • Yu-Chen Hao
    • Ji-Zhong Han
    • Liangchao Qu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, P.R. China, Department of Oncology, JiangXi Provincial People's Hospital, Donghu, Nanchang, Jiangxi 330000, P.R. China, Medicine school of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23220, USA
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 441
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    Published online on: February 28, 2021
       https://doi.org/10.3892/etm.2021.9879
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Abstract

Acid preconditioning (APC) through carbon dioxide inhalation can exert protective effects during acute lung injury (ALI) triggered by ischemia‑reperfusion. Angiotensin‑converting enzyme 2 (ACE2) has been identified as a receptor for severe acute respiratory syndrome coronavirus and the novel coronavirus disease‑19. Downregulation of ACE2 plays an important role in the pathogenesis of severe lung failure after viral or bacterial infections. The aim of the present study was to examine the anti‑inflammatory mechanism through which APC alleviates lipopolysaccharide (LPS)‑induced ALI in vivo and in vitro. The present results demonstrated that LPS significantly downregulated the expression of ACE2, while APC significantly reduced LPS‑induced ALI and provided beneficial effects. In addition, bioinformatics analysis indicated that microRNA (miR)‑200c‑3p directly targeted the 3'untranslated region of ACE2 and regulated the expression of ACE2 protein. LPS exposure inhibited the expression of ACE2 protein in A549 cells by upregulating the levels of miR‑200c‑3p. However, APC inhibited the upregulation of miR‑200c‑3p induced by LPS, as well as the downregulation of ACE2 protein, through the NF‑κB pathway. In conclusion, although LPS can inhibit the expression of ACE2 by upregulating the levels of miR‑200c‑3p through the NF‑κB pathway, APC inhibited this effect, thus reducing inflammation during LPS‑induced ALI.
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1 

Ijland MM, Heunks LM and van der Hoeven JG: Bench-to-bedside review: Hypercapnic acidosis in lung injury-from ‘permissive’ to ‘therapeutic’. Crit Care. 14(237)2010.PubMed/NCBI View Article : Google Scholar

2 

Tan J, Liu Y, Jiang T, Wang L, Zhao C, Shen D and Cui X: Effects of hypercapnia on acute cellular rejection after lung transplantation in rats. Anesthesiology. 128:130–139. 2018.PubMed/NCBI View Article : Google Scholar

3 

Shigemura M, Lecuona E and Sznajder JI: Effects of hypercapnia on the lung. J Physiol. 595:2431–2437. 2017.PubMed/NCBI View Article : Google Scholar

4 

Laffey JG and Kavanagh BP: Hypocapnia. N Engl J Med. 347:43–53. 2002.PubMed/NCBI View Article : Google Scholar

5 

Contreras M, Masterson C and Laffey JG: Permissive hypercapnia: What to remember. Curr Opin Anesthesiol. 28:26–37. 2015.PubMed/NCBI View Article : Google Scholar

6 

Qu LC, Jiao Y, Jiang ZJ, Song ZP and Peng QH: Acidic preconditioning protects against ischemia-reperfusion lung injury via inhibiting the expression of matrix metalloproteinase 9. J Surg Res. 235:569–577. 2019.PubMed/NCBI View Article : Google Scholar

7 

Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, et al: Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417:822–828. 2002.PubMed/NCBI View Article : Google Scholar

8 

Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM and Raizada MK: Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Exp Physiol. 90:783–790. 2005.PubMed/NCBI View Article : Google Scholar

9 

Abdul-Hafez A, Mohamed T, Omar H, Shemis M and Uhal BD: The renin angiotensin system in liver and lung: Impact and therapeutic potential in organ fibrosis. J Lung Pulm Respir Res. 5(00160)2018.PubMed/NCBI

10 

Oudit GY and Penninger JM: Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy. Curr Heart Fail Rep. 8:176–183. 2011.PubMed/NCBI View Article : Google Scholar

11 

Chappell MC, Marshall AC, Alzayadneh EM, Shaltout HA and Diz DI: Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: Fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne). 4(201)2014.PubMed/NCBI View Article : Google Scholar

12 

Kuba K, Imai Y, Ohto-Nakanishi T and Penninger JM: Trilogy of ACE2: A peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 128:119–128. 2010.PubMed/NCBI View Article : Google Scholar

13 

Cheng H, Wang Y and Wang GQ: Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19. J Med Virol. 92:726–730. 2020.PubMed/NCBI View Article : Google Scholar

14 

Contini C, Di Nuzzo M, Barp N, Bonazza A, De Giorgio R, Tognon M and Rubino S: The novel zoonotic COVID-19 pandemic: An expected global health concern. J Infect Dev Ctries. 14:254–264. 2020.PubMed/NCBI View Article : Google Scholar

15 

Danser AJ, Epstein M and Batlle D: Renin-angiotensin system blockers and the COVID-19 pandemic: At present there is no evidence to abandon renin-angiotensin system blockers. Hypertension. 175:1382–1385. 2020.PubMed/NCBI View Article : Google Scholar

16 

Chen Q, Liu J, Wang W, Liu S, Yang X, Chen M, Cheng L, Lu J, Guo T and Huang F: Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway. Biomed Pharmacother. 115(108971)2019.PubMed/NCBI View Article : Google Scholar

17 

Li Y, Zeng Z, Cao Y, Liu Y, Ping F, Liang M, Xue Y, Xi C, Zhou M and Jiang W: Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-κB signaling pathways. Sci Rep. 6(27911)2016.PubMed/NCBI View Article : Google Scholar

18 

Liu Q, Du J, Yu X, Xu J, Huang F, Li X, Zhang C, Li X, Chang J, Shang D, et al: miRNA-200c-3p is crucial in acute respiratory distress syndrome. Cell Discov. 3(17021)2017.PubMed/NCBI View Article : Google Scholar

19 

Zhang X, Huang H, Yang T, Ye Y, Shan J, Yin Z and Luo L: Chlorogenic acid protects mice against lipopolysaccharide-induced acute lung injury. Injury. 41:746–752. 2010.PubMed/NCBI View Article : Google Scholar

20 

Zhang CH, Fan YY, Wang XF, Xiong JY, Tang YY, Gao JQ, Shen Z, Song XH, Zhang JY, Shen Y, et al: Acidic preconditioning protects against ischemia-induced brain injury. Neurosci Lett. 523:3–8. 2012.PubMed/NCBI View Article : Google Scholar

21 

Gu H, Xie Z, Li T, Zhang S, Lai C, Zhu P, Wang K, Han L, Duan Y, Zhao Z, et al: Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep. 6(19840)2016.PubMed/NCBI View Article : Google Scholar

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

23 

Ye R and Liu Z: ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway. Exp Mol Pathol. 113(104350)2020.PubMed/NCBI View Article : Google Scholar

24 

Niu J, Shi Y, Tan G, Yang CH, Fan M, Pfeffer LM and Wu ZH: DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion. J Biol Chem. 287:21783–21795. 2012.PubMed/NCBI View Article : Google Scholar

25 

Zhou R, Hu G, Liu J, Gong AY, Drescher KM and Chen XM: NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses. PLoS Pathog. 5(e1000681)2009.PubMed/NCBI View Article : Google Scholar

26 

Minato T, Nirasawa S, Sato T, Yamaguchi T, Hoshizaki M, Inagaki T, Nakahara K, Yoshihashi T, Ozawa R, Yokota S, et al: B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nat Commun. 11(1058)2020.PubMed/NCBI View Article : Google Scholar

27 

Celec P: Nuclear factor kappa B-molecular biomedicine: The next generation. Biomed Pharmacother. 58:365–371. 2004.PubMed/NCBI View Article : Google Scholar

28 

Kvandova M and Dovinova I: Functioning of the PPAR gamma and its effect on cardiovascular and metabolic Diseases. In: Metabolic Syndrome, edition: 160 Greentree Drive, Suite 101, Dover, DE 19904, USA, pp1-41, 2017 http://smgebooks.com/metabolic-syndrome/index.php.

29 

Passos-Silva DG, Verano-Braga T and Santos RA: Angiotensin-(1-7): Beyond the cardio-renal actions. Clin Sci. 124:443–456. 2013.PubMed/NCBI View Article : Google Scholar

30 

Rodrigues Prestes TR, Rocha NP, Miranda AS, Teixeira AL and Simoes-E-Silva AC: The anti-inflammatory potential of ACE2/angiotensin-(1-7)/mas receptor axis: evidence from basic and clinical research. Current Drug Targets. 18:1301–1313. 2017.PubMed/NCBI View Article : Google Scholar

31 

Kuba K, Imai Y, Rao S, Jiang C and Penninger JM: Lessons from SARS: Control of acute lung failure by the SARS receptor ACE2. J Mol Med. 84:814–820. 2006.PubMed/NCBI View Article : Google Scholar

32 

Zou Z, Yan Y, Shu Y, Gao R, Sun Y, Li X, Ju X, Liang Z, Liu Q, Zhao Y, et al: Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 5(3594)2014.PubMed/NCBI View Article : Google Scholar

33 

Wang J, Zhao S, Liu M, Zhao Z, Xu Y, Wang P, Lin M, Xu Y, Huang B, Zuo X, et al: ACE2 expression by colonic epithelial cells is associated with viral infection, immunity and energy metabolism. medRxiv, Feb 7, 2020 doi: https://doi.org/10.1101/2020.02.05.20020545.

34 

Gralinski LE, Sheahan TP, Morrison TE, Menachery VD, Jensen K, Leist SR, Whitmore A, Heise MT and Baric RS: Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis. MBio. 9:e01753–18. 2018.PubMed/NCBI View Article : Google Scholar

35 

Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, et al: Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 436:112–116. 2005.PubMed/NCBI View Article : Google Scholar

36 

Ebert MS and Sharp PA: Emerging roles for natural microRNA sponges. Curr Biol. 20:R858–R861. 2010.PubMed/NCBI View Article : Google Scholar

37 

Christopher AF, Kaur RP, Kaur G, Kaur A, Gupta V and Bansal P: MicroRNA therapeutics: Discovering novel targets and developing specific therapy. Perspect Clin Res. 7:68–74. 2016.PubMed/NCBI View Article : Google Scholar

38 

Magenta A, Greco S, Gaetano C and Martelli F: Oxidative stress and microRNAs in vascular diseases. Int J Mol Sci. 14:17319–17346. 2013.PubMed/NCBI View Article : Google Scholar

39 

Zhang HN, Xu QQ, Thakur A, Alfred MO, Chakraborty M, Ghosh A and Yu XB: Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs. Life Sci. 213:258–268. 2018.PubMed/NCBI View Article : Google Scholar

40 

Caballero AE: Endothelial dysfunction in obesity and insulin resistance: A road to diabetes and heart disease. Obes Res. 11:1278–1289. 2003.PubMed/NCBI View Article : Google Scholar

41 

Alexopoulou L, Holt AC, Medzhitov R and Flavell RA: Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature. 413:732–738. 2001.PubMed/NCBI View Article : Google Scholar

42 

Uchida T, Shirasawa M, Ware LB, Kojima K, Hata Y, Makita K, Mednick G, Matthay ZA and Matthay MA: Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Am J Respir Criti Care Med. 173:1008–1015. 2006.PubMed/NCBI View Article : Google Scholar

43 

Proudfoot AG, McAuley DF, Griffiths MJ and Hind M: Human models of acute lung injury. Dis Models Mech. 4:145–153. 2011.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yu G, Jiao Y, Huang J, Fan M, Hao Y, Han J and Qu L: Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2. Exp Ther Med 21: 441, 2021.
APA
Yu, G., Jiao, Y., Huang, J., Fan, M., Hao, Y., Han, J., & Qu, L. (2021). Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2. Experimental and Therapeutic Medicine, 21, 441. https://doi.org/10.3892/etm.2021.9879
MLA
Yu, G., Jiao, Y., Huang, J., Fan, M., Hao, Y., Han, J., Qu, L."Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2". Experimental and Therapeutic Medicine 21.5 (2021): 441.
Chicago
Yu, G., Jiao, Y., Huang, J., Fan, M., Hao, Y., Han, J., Qu, L."Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2". Experimental and Therapeutic Medicine 21, no. 5 (2021): 441. https://doi.org/10.3892/etm.2021.9879
Copy and paste a formatted citation
x
Spandidos Publications style
Yu G, Jiao Y, Huang J, Fan M, Hao Y, Han J and Qu L: Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2. Exp Ther Med 21: 441, 2021.
APA
Yu, G., Jiao, Y., Huang, J., Fan, M., Hao, Y., Han, J., & Qu, L. (2021). Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2. Experimental and Therapeutic Medicine, 21, 441. https://doi.org/10.3892/etm.2021.9879
MLA
Yu, G., Jiao, Y., Huang, J., Fan, M., Hao, Y., Han, J., Qu, L."Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2". Experimental and Therapeutic Medicine 21.5 (2021): 441.
Chicago
Yu, G., Jiao, Y., Huang, J., Fan, M., Hao, Y., Han, J., Qu, L."Acidic preconditioning reduces lipopolysaccharide‑induced acute lung injury by upregulating the expression of angiotensin‑converting enzyme 2". Experimental and Therapeutic Medicine 21, no. 5 (2021): 441. https://doi.org/10.3892/etm.2021.9879
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