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Article

Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein

  • Authors:
    • Yue Shen
    • Wei Ma
    • Ying Hang
    • Li-Li Liu
    • Wei Jiang
    • Sheng-Di Wu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China, Department of Emergency, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201204, P.R. China
  • Article Number: 442
    |
    Published online on: February 28, 2021
       https://doi.org/10.3892/etm.2021.9881
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Abstract

The clinical outcomes differ between patients with cavernous transformation of the portal vein (CTPV) with and without cirrhosis. Therefore, invasive liver biopsy may be needed for the differential diagnosis of patients with CTPV with or without cirrhosis. The present study aimed to investigate the diagnostic efficacy of liver stiffness measurements (LSM) for the prediction of cirrhosis in patients with CTPV. A total of 20 patients with CTPV, 34 with chronic hepatitis B (CHB)‑related cirrhosis and 20 healthy volunteers, were retrospectively recruited in the study. CTPV was diagnosed with contrast‑enhanced computed tomography (CT) and ultrasound for the abdomen. LSM values were detected for each patient, while liver biopsy was performed in each patient in the CTPV and cirrhosis groups. The results demonstrated that LSM values were significantly lower in the CTPV group (12.5 kPa; range, 6.8‑21.5 kPa) compared with the CHB‑related cirrhosis group (21.0 kPa; range, 15.5‑27.2 kPa; P=0.017). However, this was still higher compared with healthy volunteers (4.9 kPa; range 4.0‑5.8 kPa; P<0.001). In addition, CTPV patients with cirrhosis (17.7 kPa; range, 13.9‑30.8 kPa) exhibited significantly increased LSM values compared with those without cirrhosis (6.4 kPa; range, 5.7‑7.8 kPa; P<0.001). Furthermore, LSM values in CTPV patients without cirrhosis were slightly higher compared with those of healthy volunteers (P=0.003), while no statistically significant difference was observed in LSM between CTPV patients with cirrhosis and CHB‑related cirrhosis group. These findings indicated that LSM values could be used for the differential diagnosis of CTPV patients with or without cirrhosis. However, further validation studies are needed.
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Copy and paste a formatted citation
Spandidos Publications style
Shen Y, Ma W, Hang Y, Liu L, Jiang W and Wu S: Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein. Exp Ther Med 21: 442, 2021.
APA
Shen, Y., Ma, W., Hang, Y., Liu, L., Jiang, W., & Wu, S. (2021). Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein. Experimental and Therapeutic Medicine, 21, 442. https://doi.org/10.3892/etm.2021.9881
MLA
Shen, Y., Ma, W., Hang, Y., Liu, L., Jiang, W., Wu, S."Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein". Experimental and Therapeutic Medicine 21.5 (2021): 442.
Chicago
Shen, Y., Ma, W., Hang, Y., Liu, L., Jiang, W., Wu, S."Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein". Experimental and Therapeutic Medicine 21, no. 5 (2021): 442. https://doi.org/10.3892/etm.2021.9881
Copy and paste a formatted citation
x
Spandidos Publications style
Shen Y, Ma W, Hang Y, Liu L, Jiang W and Wu S: Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein. Exp Ther Med 21: 442, 2021.
APA
Shen, Y., Ma, W., Hang, Y., Liu, L., Jiang, W., & Wu, S. (2021). Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein. Experimental and Therapeutic Medicine, 21, 442. https://doi.org/10.3892/etm.2021.9881
MLA
Shen, Y., Ma, W., Hang, Y., Liu, L., Jiang, W., Wu, S."Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein". Experimental and Therapeutic Medicine 21.5 (2021): 442.
Chicago
Shen, Y., Ma, W., Hang, Y., Liu, L., Jiang, W., Wu, S."Clinical application of liver stiffness measurement in patients with cavernous transformation of portal vein". Experimental and Therapeutic Medicine 21, no. 5 (2021): 442. https://doi.org/10.3892/etm.2021.9881
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