Open Access

Actin-binding protein anillin promotes the progression of hepatocellular carcinoma in vitro and in mice

  • Authors:
    • Huanxia Jia
    • Zhenya Gao
    • Fang Yu
    • Hongfang Guo
    • Baoyu Li
  • View Affiliations

  • Published online on: March 1, 2021     https://doi.org/10.3892/etm.2021.9885
  • Article Number: 454
  • Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatocellular carcinoma (HCC) is a common type of tumor with high mortality worldwide. Investigations associated with the molecular etiology of HCC and screening novel therapeutic targets are still urgently in need. Anillin (ANLN), as a type of evolutionarily conserved actin‑binding protein, is involved in multiple cellular processes. ANLN widely affected the progression and metastasis of several types of cancer, and its overexpression was frequently demonstrated in previous studies. The present study demonstrated high expression of ANLN in human HCC tissues, which was also associated the prognosis of patients with HCC. The associations between ANLN expression and the clinicopathological features were determined, including the number of tumor nodes (P=0.011) and tumor size (P=0.003) of patients with HCC. It was found that ANLN promoted cell proliferation, invasion and migration of HCC cells in vitro, and affected tumor growth in vivo. Therefore, ANLN is suggested as a promising therapeutic target for the treatment of HCC.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Jia H, Gao Z, Yu F, Guo H and Li B: Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice. Exp Ther Med 21: 454, 2021
APA
Jia, H., Gao, Z., Yu, F., Guo, H., & Li, B. (2021). Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice. Experimental and Therapeutic Medicine, 21, 454. https://doi.org/10.3892/etm.2021.9885
MLA
Jia, H., Gao, Z., Yu, F., Guo, H., Li, B."Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice". Experimental and Therapeutic Medicine 21.5 (2021): 454.
Chicago
Jia, H., Gao, Z., Yu, F., Guo, H., Li, B."Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice". Experimental and Therapeutic Medicine 21, no. 5 (2021): 454. https://doi.org/10.3892/etm.2021.9885