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Actin-binding protein anillin promotes the progression of hepatocellular carcinoma in vitro and in mice

Retraction in: /10.3892/etm.2023.12120
  • Authors:
    • Huanxia Jia
    • Zhenya Gao
    • Fang Yu
    • Hongfang Guo
    • Baoyu Li
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Xuchang University, Xuchang, Henan 461000, P.R. China, Department of General Surgery, The Secondary Hospital of Tianjin Medical University, Tianjin 300211, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 454
    |
    Published online on: March 1, 2021
       https://doi.org/10.3892/etm.2021.9885
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Abstract

Hepatocellular carcinoma (HCC) is a common type of tumor with high mortality worldwide. Investigations associated with the molecular etiology of HCC and screening novel therapeutic targets are still urgently in need. Anillin (ANLN), as a type of evolutionarily conserved actin‑binding protein, is involved in multiple cellular processes. ANLN widely affected the progression and metastasis of several types of cancer, and its overexpression was frequently demonstrated in previous studies. The present study demonstrated high expression of ANLN in human HCC tissues, which was also associated the prognosis of patients with HCC. The associations between ANLN expression and the clinicopathological features were determined, including the number of tumor nodes (P=0.011) and tumor size (P=0.003) of patients with HCC. It was found that ANLN promoted cell proliferation, invasion and migration of HCC cells in vitro, and affected tumor growth in vivo. Therefore, ANLN is suggested as a promising therapeutic target for the treatment of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Jia H, Gao Z, Yu F, Guo H and Li B: Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Retraction in /10.3892/etm.2023.12120. Exp Ther Med 21: 454, 2021.
APA
Jia, H., Gao, Z., Yu, F., Guo, H., & Li, B. (2021). Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Retraction in /10.3892/etm.2023.12120. Experimental and Therapeutic Medicine, 21, 454. https://doi.org/10.3892/etm.2021.9885
MLA
Jia, H., Gao, Z., Yu, F., Guo, H., Li, B."Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Retraction in /10.3892/etm.2023.12120". Experimental and Therapeutic Medicine 21.5 (2021): 454.
Chicago
Jia, H., Gao, Z., Yu, F., Guo, H., Li, B."Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Retraction in /10.3892/etm.2023.12120". Experimental and Therapeutic Medicine 21, no. 5 (2021): 454. https://doi.org/10.3892/etm.2021.9885
Copy and paste a formatted citation
x
Spandidos Publications style
Jia H, Gao Z, Yu F, Guo H and Li B: Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Retraction in /10.3892/etm.2023.12120. Exp Ther Med 21: 454, 2021.
APA
Jia, H., Gao, Z., Yu, F., Guo, H., & Li, B. (2021). Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Retraction in /10.3892/etm.2023.12120. Experimental and Therapeutic Medicine, 21, 454. https://doi.org/10.3892/etm.2021.9885
MLA
Jia, H., Gao, Z., Yu, F., Guo, H., Li, B."Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Retraction in /10.3892/etm.2023.12120". Experimental and Therapeutic Medicine 21.5 (2021): 454.
Chicago
Jia, H., Gao, Z., Yu, F., Guo, H., Li, B."Actin-binding protein anillin promotes the progression of hepatocellular carcinoma <em>in vitro</em> and in mice Retraction in /10.3892/etm.2023.12120". Experimental and Therapeutic Medicine 21, no. 5 (2021): 454. https://doi.org/10.3892/etm.2021.9885
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