Clinical diagnostic value of combined detection of IMA, D‑D and MCP‑1 in acute myocardial infarction

Ding,Mei; Li,Min; Yang,Hailing

doi:10.3892/etm.2021.9888

Clinical diagnostic value of combined detection of IMA, D‑D and MCP‑1 in acute myocardial infarction

Authors:
- Mei Ding
- Min Li
- Hailing Yang
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Affiliations: Department of Cardiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Clinical Laboratory, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Emergency, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
Published online on: March 2, 2021 https://doi.org/10.3892/etm.2021.9888
Article Number: 457
Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the study was to analyze the clinical value of the combined detection of ischemia‑modified albumin (IMA), D‑dimer (D‑D) and monocyte chemoattractant protein‑1 (MCP‑1) in the diagnosis of acute myocardial infarction (AMI). Altogether 87 patients with AMI from January 2017 to January 2018 were enrolled in the AMI group, and 82 patients without coronary artery disease were included in the control group. The serum levels of IMA, D‑D, MCP‑1, cardiac troponin (CTnT) and high‑sensitivity C‑reactive protein (hs‑CRP) in the two groups were detected by ELISA. The blood lipids of the two groups and the levels of IMA, D‑D, MCP‑1 after treatment were detected. The association between IMA, D‑D, MCP‑1, CTnT, hs‑CRP and blood lipid in patients with AMI was analyzed. The values of IMA, D‑D, and MCP‑1 alone and combined in the diagnosis of AMI were analyzed by ROC curve. The levels of IMA, D‑D, MCP‑1, CTnT and hs‑CRP in the AMI group were significantly higher than those in the control group (P<0.05). The levels of IMA, D‑D and MCP‑1 in the patients with poor prognosis were significantly higher than those of the good prognosis group (P<0.05). The changes of IMA, D‑D and MCP‑1 levels were positively correlated with the levels of CTT and hs‑CRP (P<0.05). The AUC, specificity and sensitivity of patients with AMI diagnosed with MCP‑1 alone were 0.8084, 81.61 and 69.51%, respectively. Those of patients diagnosed by D‑D were 0.7302, 59.77 and 81.71%, those of patients diagnosed by IMA alone were 0.7289, 58.62 and 80.49%, and those of patients detected by the combination of MCP‑1, D‑D and IMA were 0.9047, 58.62 and 93.90%. In conclusion, the levels of IMA, D‑D and MCP‑1 in AMI patients are higher than those in the control group. The levels of IMA, D‑D and MCP‑1 were positively correlated with CTnT and hs‑CRP levels in AMI patients. Combined detection of IMA, D‑D, and MCP‑1 can improve the accuracy.

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1	Boersma E, Mercado N, Poldermans D, Gardien M, Vos J and Simoons ML: Acute myocardial infarction. Lancet. 361:847–858. 2003.PubMed/NCBI View Article : Google Scholar
2	Rumana N, Kita Y, Turin TC, Murakami Y, Sugihara H, Morita Y, Tomioka N, Okayama A, Nakamura Y, Abbott RD and Ueshima H: Trend of increase in the incidence of acute myocardial infarction in a Japanese population: Takashima AMI registry, 1990-2001. Am J Epidemiol. 167:1358–1364. 2008.PubMed/NCBI View Article : Google Scholar
3	Ferrières J, Cambou JP, Ruidavets JB and Pous J: Trends in acute myocardial infarction prognosis and treatment in southwestern France between 1985 and 1990 (the MONICA Project-Toulouse). Am J Cardiol. 75:1202–1205. 1995.PubMed/NCBI View Article : Google Scholar
4	Anderson JL and Morrow DA: Acute myocardial infarction. N Engl J Med. 376:2053–2064. 2017.PubMed/NCBI View Article : Google Scholar
5	Açıkgöz Ş, Edebali N, Barut F, Can M, Tekin İÖ, Büyükuysal Ç and Açıkgöz B: Ischemia modified albumin increase indicating cardiac damage after experimental subarachnoid hemorrhage. BMC Neurosci. 15(33)2014.PubMed/NCBI View Article : Google Scholar
6	Tripodi A: D-dimer testing in laboratory practice. Clin Chem. 57:1256–1262. 2011.PubMed/NCBI View Article : Google Scholar
7	Andreescu AC, Cushman M and Rosendaal FR: D-dimer as a risk factor for deep vein thrombosis: The Leiden thrombophilia study. Thromb Haemost. 87:47–51. 2002.PubMed/NCBI
8	Lloyd CM, Minto AW, Dorf ME, Proudfoot A, Wells TN, Salant DJ and Gutierrez-Ramos JC: RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J Exp Med. 185:1371–1380. 1997.PubMed/NCBI View Article : Google Scholar
9	Ryan TJ, Antman EM, Brooks NH, Califf RM, Hillis LD, Hiratzka LF, Rapaport E, Riegel B, Russell RO, Smith EE III, et al: 1999 update: ACC/AHA guidelines for the management of patients with acute myocardial infarction. A report of the American college of cardiology/American heart association task force on practice guidelines (committee on management of acute myocardial infarction). J Am Coll Cardiol. 34:890–911. 1999.PubMed/NCBI View Article : Google Scholar
10	Gong X, Zhou R and Li Q: Effects of captopril and valsartan on ventricular remodeling and inflammatory cytokines after interventional therapy for AMI. Exp Ther Med. 16:3579–3583. 2018.PubMed/NCBI View Article : Google Scholar
11	Rubinfeld GD, Smilowitz NR, Berger JS and Newman JD: Association of thrombocytopenia, revascularization, and in-hospital outcomes in patients with acute myocardial infarction. Am J Med. 132:942–948.e5. 2019.PubMed/NCBI View Article : Google Scholar
12	Rasmussen MB, Stengaard C, Sørensen JT, Riddervold IS, Hansen TM, Giebner M, Rasmussen CH, Bøtker HE and Terkelsen CJ: Predictive value of routine point-of-care cardiac troponin T measurement for prehospital diagnosis and risk-stratification in patients with suspected acute myocardial infarction. Eur Heart J Acute Cardiovasc Care. 8:299–308. 2019.PubMed/NCBI View Article : Google Scholar
13	Gruber HE, Hoelscher GL, Ingram JA, Bethea S, Cox M and Hanley EN Jr: Proinflammatory cytokines modulate the chemokine CCL2 (MCP-1) in human annulus cells in vitro: CCL2 expression and production. Exp Mol Pathol. 98:102–105. 2015.PubMed/NCBI View Article : Google Scholar
14	Niu J and Kolattukudy PE: Role of MCP-1 in cardiovascular disease: Molecular mechanisms and clinical implications. Clin Sci (Lond). 117:95–109. 2009.PubMed/NCBI View Article : Google Scholar
15	Buitrago L, Zafar H, Zhang Y, Li J, Walz T and Coller BS: Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer. Blood Adv. 4:2939–2949. 2020.PubMed/NCBI View Article : Google Scholar
16	Simes J, Robledo KP, White HD, Espinoza D, Stewart RA, Sullivan DR, Zeller T, Hague W, Nestel PJ, Glasziou PP, et al: D-dimer predicts long-term cause-specific mortality, cardiovascular events, and cancer in patients with stable coronary heart disease: LIPID Study: LIPID Study. Circulation. 138:712–723. 2018.PubMed/NCBI View Article : Google Scholar
17	Shaw E, Massaro J, Levy D, O'Donnell CJ, D'Agostino R and Tofler G: D-dimer and the risk of cardiovascular disease: The Framingham heart study. Heart Lung Circ. 20 (Suppl 2)(S30)2011.
18	Kim KS, Shin SD, Song KJ, Suh GJ and Shin S: Prognosis of patients with out-of-hospital cardiac arrest and early biochemical markers: Ischemia modified albumin, procalictonin, and S-100 protein. J Korean Soc Emerg Med. 17:281–290. 2006.
19	Sokhanvar S, Mellati AO, Mousavinasab SN, Taran L, Vahdani B and Golmmohamadi Z: Ischemia-modified albumin (IMA) in differential diagnosis of transient myocardial ischemia from non ischemic chest pain. Bratisl Lek Listy. 113:612–615. 2012.PubMed/NCBI View Article : Google Scholar
20	Zhong Y, Wang N and Xu H: The value of ischaemia modified albumin in the diagnosis on coronary atherosclerotic heart disease. Heart. 97 (Suppl 3)(A134)2011.PubMed/NCBI View Article : Google Scholar
21	Zhang CL, Jiang YM, Gao X and Wang X: Clinical value of h-FABP, hs-CRP, cTnT examination to diagnose acute myocardial infarction. J Dalian Med Univ. 30:170–172. 2008.
22	Devaki RN, Suma MN, Gowdappa HB, et al: HS-CRP levels in myocardial infarction patients in relation to cardiac markers, 2011.
23	Keller T, Zeller T, Peetz D, Tzikas S, Roth A, Czyz E, Bickel C, Baldus S, Warnholtz A, Fröhlich M, et al: Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med. 361:868–877. 2009.PubMed/NCBI View Article : Google Scholar
24	Chan D and Ng LL: Biomarkers in acute myocardial infarction. BMC Med. 8(34)2010.PubMed/NCBI View Article : Google Scholar