Open Access

Research advances in chimeric antigen receptor-modified T-cell therapy (Review)

  • Authors:
    • Yuxi Luo
    • Guiqin Song
    • Shichu Liang
    • Feifei Li
    • Kang Liu
  • View Affiliations

  • Published online on: March 16, 2021     https://doi.org/10.3892/etm.2021.9915
  • Article Number: 484
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Chimeric antigen receptor (CAR)-modified T-cells are T-cells that have been genetically engineered to express CAR molecules to target specific surface antigens on tumor cells. CAR T-cell therapy, a novel cancer immunotherapy, has been attracting increasing attention, since it exhibited notable efficacy in the treatment of hematological tumors in clinical trials. However, for this type of therapy, challenges must be overcome in the treatment of solid tumors. Furthermore, certain side effects associated with CAR T-cell therapy, including cytokine release syndrome, immune effector cell-related neurotoxicity syndrome, tumor lysis syndrome and on-target off-tumor toxicity, must be taken into consideration. The present study provides a systematic review of the principle, clinical application, current challenges, possible solutions and future perspectives for CAR T-cell therapy.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Luo Y, Song G, Liang S, Li F and Liu K: Research advances in chimeric antigen receptor-modified T-cell therapy (Review). Exp Ther Med 21: 484, 2021
APA
Luo, Y., Song, G., Liang, S., Li, F., & Liu, K. (2021). Research advances in chimeric antigen receptor-modified T-cell therapy (Review). Experimental and Therapeutic Medicine, 21, 484. https://doi.org/10.3892/etm.2021.9915
MLA
Luo, Y., Song, G., Liang, S., Li, F., Liu, K."Research advances in chimeric antigen receptor-modified T-cell therapy (Review)". Experimental and Therapeutic Medicine 21.5 (2021): 484.
Chicago
Luo, Y., Song, G., Liang, S., Li, F., Liu, K."Research advances in chimeric antigen receptor-modified T-cell therapy (Review)". Experimental and Therapeutic Medicine 21, no. 5 (2021): 484. https://doi.org/10.3892/etm.2021.9915