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Research advances in chimeric antigen receptor-modified T-cell therapy (Review)

  • Authors:
    • Yuxi Luo
    • Guiqin Song
    • Shichu Liang
    • Feifei Li
    • Kang Liu
  • View Affiliations / Copyright

    Affiliations: Institute of Tissue Engineering and Stem Cells, Nanchong Central Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Biology, North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, The First Clinic of Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Pathophysiology, Anhui Medical University, Hefei, Anhui 230032, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 484
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    Published online on: March 16, 2021
       https://doi.org/10.3892/etm.2021.9915
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Abstract

Chimeric antigen receptor (CAR)-modified T-cells are T-cells that have been genetically engineered to express CAR molecules to target specific surface antigens on tumor cells. CAR T-cell therapy, a novel cancer immunotherapy, has been attracting increasing attention, since it exhibited notable efficacy in the treatment of hematological tumors in clinical trials. However, for this type of therapy, challenges must be overcome in the treatment of solid tumors. Furthermore, certain side effects associated with CAR T-cell therapy, including cytokine release syndrome, immune effector cell-related neurotoxicity syndrome, tumor lysis syndrome and on-target off-tumor toxicity, must be taken into consideration. The present study provides a systematic review of the principle, clinical application, current challenges, possible solutions and future perspectives for CAR T-cell therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Luo Y, Song G, Liang S, Li F and Liu K: Research advances in chimeric antigen receptor-modified T-cell therapy (Review). Exp Ther Med 21: 484, 2021.
APA
Luo, Y., Song, G., Liang, S., Li, F., & Liu, K. (2021). Research advances in chimeric antigen receptor-modified T-cell therapy (Review). Experimental and Therapeutic Medicine, 21, 484. https://doi.org/10.3892/etm.2021.9915
MLA
Luo, Y., Song, G., Liang, S., Li, F., Liu, K."Research advances in chimeric antigen receptor-modified T-cell therapy (Review)". Experimental and Therapeutic Medicine 21.5 (2021): 484.
Chicago
Luo, Y., Song, G., Liang, S., Li, F., Liu, K."Research advances in chimeric antigen receptor-modified T-cell therapy (Review)". Experimental and Therapeutic Medicine 21, no. 5 (2021): 484. https://doi.org/10.3892/etm.2021.9915
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Y, Song G, Liang S, Li F and Liu K: Research advances in chimeric antigen receptor-modified T-cell therapy (Review). Exp Ther Med 21: 484, 2021.
APA
Luo, Y., Song, G., Liang, S., Li, F., & Liu, K. (2021). Research advances in chimeric antigen receptor-modified T-cell therapy (Review). Experimental and Therapeutic Medicine, 21, 484. https://doi.org/10.3892/etm.2021.9915
MLA
Luo, Y., Song, G., Liang, S., Li, F., Liu, K."Research advances in chimeric antigen receptor-modified T-cell therapy (Review)". Experimental and Therapeutic Medicine 21.5 (2021): 484.
Chicago
Luo, Y., Song, G., Liang, S., Li, F., Liu, K."Research advances in chimeric antigen receptor-modified T-cell therapy (Review)". Experimental and Therapeutic Medicine 21, no. 5 (2021): 484. https://doi.org/10.3892/etm.2021.9915
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