Clinical significance of the long non‑coding RNA NEAT1/miR‑129‑5p axis in the diagnosis and prognosis for patients with chronic heart failure
- Haohua Zhang
- Nianli Zhang
- Wenbin Jiang
- Xiaoqin Lun
Affiliations: Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China, Department of Cardiovascular Surgery, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China
- Published online on: March 19, 2021 https://doi.org/10.3892/etm.2021.9943
Copyright: © Zhang
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Chronic heart failure (CHF) is the leading cause of death worldwide. The regulatory interactions of long non‑coding RNA (lncRNAs) and microRNAs (miRs) have important roles in multiple diseases. However, the clinical significance of the nuclear‑enriched abundant transcript 1 (NEAT1)/miR‑129‑5p axis in CHF has remained elusive. The present study explored whether the NEAT1/miR‑129‑5p axis may be a suitable diagnostic and prognostic marker for CHF. The expression of lncRNA NEAT1 and miR‑129‑5p in the serum of patients with CHF was analyzed by reverse transcription‑quantitative PCR. Furthermore, inter‑indicator correlations were assessed by Pearson correlation coefficient analysis. Receiver operating characteristic (ROC) curves were generated to evaluate the ability of NEAT1, miR‑129‑5p and brain natriuretic peptide (BNP) to identify patients with CHF. The prognostic value of the NEAT1/miR‑129‑5p axis was analyzed by drawing Kaplan‑Meier survival curves and by Cox logistic regression analysis. Baseline data were not significantly different between CHF (n=70) and control subjects (n=62). The serum level of NEAT1 was increased and the expression level of miR‑129‑5p was decreased in patients with CHF (all P<0.001). The ROC curves suggested that serum NEAT1 and miR‑129‑5p were of diagnostic value in patients with CHF and the combined diagnostic accuracy of NEAT1, miR‑129‑5p and BNP was significantly improved. Kaplan‑Meier and multivariate Cox regression analysis suggested that low NEAT1 and high miR‑129‑5p were able to predict overall survival of patients with CHF (all P<0.01). In conclusion, the present study indicated that patients with CHF had increased NEAT1 and decreased miR‑129‑5p expression. The deregulated NEAT1/miR‑129‑5p axis may provide novel non‑invasive biomarkers for the diagnosis and prognosis of CHF.