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Article Open Access

Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells

Retraction in: /10.3892/etm.2024.12560
  • Authors:
    • Zhongcheng Zhu
    • Xiaoyi Gong
    • Jing Li
    • Yufeng Shi
    • Mingyun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Return Visit Office, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 518
    |
    Published online on: March 22, 2021
       https://doi.org/10.3892/etm.2021.9949
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Abstract

Non‑small cell lung cancer (NSCLC) is a common malignancy associated with poor clinical outcomes and high mortality rate. The association between NSCLC development and long non‑coding RNA (lncRNA) expression remains to be elucidated. The current study investigated the role of a novel lncRNA, receptor activator of nuclear factor‑κ B ligand (RANKL), in the resistance of NSCLC to chemotherapy. RANKL expression was assessed via reverse transcription‑quantitative PCR, cell death rate was evaluated using flow cytometry and sensitivity of cisplatin (DDP)‑resistant A549/DDP cells to chemotherapy was determined using the Cell Counting Kit‑8 assay. Western blotting was performed to quantify p53 protein levels. Compared with matched A549 cells, A549/DDP cells exhibited significant upregulation of RANKL expression. Sensitivity of A549/DDP cells to DDP was restored following RANKL knockdown. A549 cells overexpressing RANKL exhibited notably impaired DDP sensitivity compared with controls. Conversely, downregulated RANKL expression triggered cell death and inhibited cell migration via p53 stimulation and phosphatidylinositol 3‑kinase/protein kinase B pathway suppression. The current findings indicate that RANKL contributes to DDP resistance in NSCLC and may represent a novel therapeutic target in this malignancy.
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1 

Lin S, Nickens DJ, Patel M, Wilner KD and Tan W: Clinical implications of an analysis of pharmacokinetics of crizotinib coadministered with dexamethasone in patients with non-small cell lung cancer. Cancer Chemother Pharmacol. 84:203–211. 2019.PubMed/NCBI View Article : Google Scholar

2 

Wong ML, McMurry TL, Stukenborg GJ, Francescatti AB, Amato-Martz C, Schumacher JR, Chang GJ, Greenberg CC, Winchester DP, McKellar DP, et al: Impact of age and comorbidity on treatment of non-small cell lung cancer recurrence following complete resection: A nationally representative cohort study. Lung Cancer. 102:108–117. 2016.PubMed/NCBI View Article : Google Scholar

3 

Liu HF, Liu JS, Deng JH and Wu RR: Role of XRCC1 gene polymorphisms in non-small cell lung cancer cisplatin-based chemotherapy, and their effect on clinical and pathological characteristics. Genet Mol Res: 15, 2016 doi: 10.4238/gmr15049084.

4 

Morgensztern D and Govindan R: Adjuvant chemotherapy for lung cancer: Cisplatin doublets only? J Natl Compr Canc Netw. 6:277–284. 2008.PubMed/NCBI View Article : Google Scholar

5 

Liu Y, Cheng Z, Pang Y, Cui L, Qian T, Quan L, Zhao H, Shi J, Ke X and Fu L: Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia. J Hematol Oncol. 12(51)2019.PubMed/NCBI View Article : Google Scholar

6 

Akella A, Bhattarai S and Dharap A: Long noncoding RNAs in the pathophysiology of ischemic stroke. Neuromolecular Med. 21:474–483. 2019.PubMed/NCBI View Article : Google Scholar

7 

Chen R, Piao X, Xiao M, Wang F and Liu L: Long noncoding RNAs interact with mRNAs: A new perspective on the mechanism of premature brain injury. Neurosci Lett. 707(134274)2019.PubMed/NCBI View Article : Google Scholar

8 

Abedini P, Fattahi A, Agah S, Talebi A, Beygi AH, Amini SM, Mirzaei A and Akbari A: Expression analysis of circulating plasma long noncoding RNAs in colorectal cancer: The relevance of lncRNAs ATB and CCAT1 as potential clinical hallmarks. J Cell Physiol. 234:22028–22033. 2019.PubMed/NCBI View Article : Google Scholar

9 

Li L, Zhang X, Liu Q, Yin H, Diao Y, Zhang Z, Wang Y, Gao Y, Ren X, Li J, et al: Emerging role of HOX genes and their related long noncoding RNAs in lung cancer. Crit Rev Oncol Hematol. 139:1–6. 2019.PubMed/NCBI View Article : Google Scholar

10 

Yao G, He J, Kong Y, Zhai J, Xu Y, Yang G, Kong D, Dong F, Shi S, Yang Q and Sun Y: Transcriptional profiling of long noncoding RNAs and their target transcripts in ovarian cortical tissues from women with normal menstrual cycles and primary ovarian insufficiency. Mol Reprod Dev. 86:847–861. 2019.PubMed/NCBI View Article : Google Scholar

11 

Li S, Yue XC, Sun CY, Qin HY and Zhang XY: Prognostic value of long noncoding RNA ROR in patients with cancer in China: A systematic review and meta-analysis. Medicine (Baltimore). 98(e15758)2019.PubMed/NCBI View Article : Google Scholar

12 

Shang AQ, Wang WW, Yang YB, Gu CZ, Ji P, Chen C, Zeng BJ, Wu JL, Lu WY, Sun ZJ and Li D: Knockdown of long non-coding RNA PVT1 suppresses cell proliferation and invasion of colorectal cancer via upregulation of microRNA-214-3p. Am J Physiol Gastrointest Liver Physiol. 317:G222–G232. 2019.PubMed/NCBI View Article : Google Scholar

13 

Xu Y, Lin J, Jin Y, Chen M, Zheng H and Feng J: The miRNA hsa-miR-6515-3p potentially contributes to lncRNA H19-mediated-lung cancer metastasis. J Cell Biochem. 120:17413–17421. 2019.PubMed/NCBI View Article : Google Scholar

14 

Xue M, Shi D, Xu G and Wang W: The long noncoding RNA linc00858 promotes progress of lung cancer through miR-3182/MMP2 axis. Artif Cells Nanomed Biotechnol. 47:2091–2097. 2019.PubMed/NCBI View Article : Google Scholar

15 

Feng J, Ma J, Liu S, Wang J and Chen Y: A noncoding RNA LINC00504 interacts with c-Myc to regulate tumor metabolism in colon cancer. J Cell Biochem. 120:14725–14734. 2019.PubMed/NCBI View Article : Google Scholar

16 

Yang JR, Shi MX and Zeng Y: lncRNA HAND2-AS1 inhibits proliferation and promotes apoptosis of chronic myeloid leukemia cells by sponging with micRNA-1275. Eur Rev Med Pharmacol Sci. 23:2103–2111. 2019.PubMed/NCBI View Article : Google Scholar

17 

Zhang X, Zhang W, Jiang Y, Liu K, Ran L and Song F: Identification of functional lncRNAs in gastric cancer by integrative analysis of GEO and TCGA data. J Cell Biochem. 120:17898–17911. 2019.PubMed/NCBI View Article : Google Scholar

18 

Zhao HL, Xu SQ, Li Q, Zhao YB, Li X and Yang MP: Long noncoding RNA MIAT promotes the growth and metastasis of non-small cell lung cancer by upregulating TDP43. Eur Rev Med Pharmacol Sci. 23:3383–3389. 2019.PubMed/NCBI View Article : Google Scholar

19 

Zhao J and Liu HR: Down-regulation of long noncoding RNA DLX6-AS1 defines good prognosis and inhibits proliferation and metastasis in human epithelial ovarian cancer cells via Notch signaling pathway. Eur Rev Med Pharmacol Sci. 23:3243–3252. 2019.PubMed/NCBI View Article : Google Scholar

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

21 

Zhao H, Wang Y and Ren X: Nicotine promotes the development of non-small cell lung cancer through activating LINC00460 and PI3K/Akt signaling. Biosci Rep. 39(BSR20182443)2019.PubMed/NCBI View Article : Google Scholar

22 

Boysen M, Kityk R and Mayer MP: Hsp70- and Hsp90-mediated regulation of the conformation of p53 DNA binding domain and p53 cancer variants. Mol Cell. 74:831–843.e4. 2019.PubMed/NCBI View Article : Google Scholar

23 

Mackay HL, Moore D, Hall C, Birkbak NJ, Jamal-Hanjani M, Karim SA, Phatak VM, Pinon L, Morton JP, Swanton C, et al: Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nat Commun. 9(3070)2018.PubMed/NCBI View Article : Google Scholar

24 

Mackay HL, Moore D, Hall C, Birkbak NJ, Jamal-Hanjani M, Karim SA, Phatak VM, Pinon L, Morton JP, Swanton C, et al: Publisher correction: Genomic instability in mutant p53 cancer cells upon entotic engulfment. Nat Commun. 9(3540)2018.PubMed/NCBI View Article : Google Scholar

25 

Zhang X, Qi Z, Yin H and Yang G: Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy. Theranostics. 9:1096–1114. 2019.PubMed/NCBI View Article : Google Scholar

26 

Jiang W, Chen Y, Song X, Shao Y, Ning Z and Gu W: Pim-1 inhibitor SMI-4a suppresses tumor growth in non-small cell lung cancer via PI3K/AKT/mTOR pathway. Onco Targets Ther. 12:3043–3050. 2019.PubMed/NCBI View Article : Google Scholar

27 

Li F, Zhao S, Guo T, Li J and Gu C: The nutritional cytokine leptin promotes NSCLC by activating the PI3K/AKT and MAPK/ERK pathways in NSCLC cells in a paracrine manner. Biomed Res Int. 2019(2585743)2019.PubMed/NCBI View Article : Google Scholar

28 

Ling C, Wang X, Zhu J, Tang H, Du W, Zeng Y, Sun L, Huang JA and Liu Z: MicroRNA-4286 promotes cell proliferation, migration, and invasion via PTEN regulation of the PI3K/Akt pathway in non-small cell lung cancer. Cancer Med. 8:3520–3531. 2019.PubMed/NCBI View Article : Google Scholar

29 

Shen WM, Yin JN, Xu RJ, Xu DF and Zheng SY: Ubiquitin specific peptidase 49 inhibits non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling. Kaohsiung J Med Sci. 35:401–407. 2019.PubMed/NCBI View Article : Google Scholar

30 

Wang J, Wang HY, Shen Y, Liang D, Wang HY, Zhang SQ, Cao YX and Cao L: A novel small-molecule PI3K/Akt signaling inhibitor, W934, exhibits potent antitumor efficacy in A549 non-small-cell lung cancer. Anticancer Drugs. 30:900–908. 2019.PubMed/NCBI View Article : Google Scholar

31 

Wu DM, Zhang T, Liu YB, Deng SH, Han R, Liu T, Li J and Xu Y: The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling. Cell Death Dis. 10(349)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhu Z, Gong X, Li J, Shi Y and Zhang M: Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells Retraction in /10.3892/etm.2024.12560. Exp Ther Med 21: 518, 2021.
APA
Zhu, Z., Gong, X., Li, J., Shi, Y., & Zhang, M. (2021). Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells Retraction in /10.3892/etm.2024.12560. Experimental and Therapeutic Medicine, 21, 518. https://doi.org/10.3892/etm.2021.9949
MLA
Zhu, Z., Gong, X., Li, J., Shi, Y., Zhang, M."Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells Retraction in /10.3892/etm.2024.12560". Experimental and Therapeutic Medicine 21.5 (2021): 518.
Chicago
Zhu, Z., Gong, X., Li, J., Shi, Y., Zhang, M."Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells Retraction in /10.3892/etm.2024.12560". Experimental and Therapeutic Medicine 21, no. 5 (2021): 518. https://doi.org/10.3892/etm.2021.9949
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Z, Gong X, Li J, Shi Y and Zhang M: Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells Retraction in /10.3892/etm.2024.12560. Exp Ther Med 21: 518, 2021.
APA
Zhu, Z., Gong, X., Li, J., Shi, Y., & Zhang, M. (2021). Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells Retraction in /10.3892/etm.2024.12560. Experimental and Therapeutic Medicine, 21, 518. https://doi.org/10.3892/etm.2021.9949
MLA
Zhu, Z., Gong, X., Li, J., Shi, Y., Zhang, M."Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells Retraction in /10.3892/etm.2024.12560". Experimental and Therapeutic Medicine 21.5 (2021): 518.
Chicago
Zhu, Z., Gong, X., Li, J., Shi, Y., Zhang, M."Long non‑coding RNA receptor activator of nuclear factor‑κ B ligand promotes cisplatin resistance in non‑small cell lung cancer cells Retraction in /10.3892/etm.2024.12560". Experimental and Therapeutic Medicine 21, no. 5 (2021): 518. https://doi.org/10.3892/etm.2021.9949
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