Vital dyes in macular hole surgery

Popescu,Ioana Stella (Patoni); Mușat,Ovidiu; Stanca,Simona; Cernat,Corina Cristina (Coman); Patoni,Cristina; Negru,Serban; Teodoru,Adrian; Feier,Horia; Danielescu,Ciprian

doi:10.3892/etm.2021.9959

Vital dyes in macular hole surgery

Authors:
- Ioana Stella (Patoni) Popescu
- Ovidiu Mușat
- Simona Stanca
- Corina Cristina (Coman) Cernat
- Cristina Patoni
- Serban Negru
- Adrian Teodoru
- Horia Feier
- Ciprian Danielescu
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Affiliations: Department of Ophthalmology, ‘Victor Babeş’ University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania, Department of Ophthalmology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania, Department of Pediatrics, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Gastroenterology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania, Department of Oncology, ‘Victor Babeş’ University of Medicine and Pharmacy Timisoara, 300239 Timisoara, Romania, Department of Ophthalmology, ‘Lucian Blaga’ University of Sibiu, 550169 Sibiu, Romania, Department of Cardiovascular Surgery, ‘Victor Babeş’ University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania, Department of Ophthalmology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
Published online on: March 22, 2021 https://doi.org/10.3892/etm.2021.9959
Article Number: 527
Copyright: © Popescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Currently, surgical techniques, such as internal limiting membrane peeling, are used widely for macular holes, macular puckers, epiretinal membranes, diabetic macular edema, retinal detachment, retinal vein occlusions, vitreomacular traction, optic pit maculopathy, and Terson syndrome. This study aimed to highlight any differences regarding visual acuity and ocular tomography coherence changes after staining the internal limiting membrane with dilutions of Brilliant Blue G vs. lutein/zeaxanthin‑based dyes. This study involved 30 eyes of 30 patients who had undergone posterior pole vitrectomy for idiopathic stage 4 macular hole. The study lot was divided in two subgroups, 15 eyes colored with Brilliant Blue and the other 15 eyes colored with lutein and zeaxanthin dyes. The association between visual prognosis, ocular tomography coherence changes and intraocular pressure was analyzed. The surgical treatment with required endoillumination levels and a 2‑min period of dye using the Alcon Constellation Vision System had no negative impact on cell viability and improved visual acuity by 30%. Staining makes it easier to remove, to be quick and precise while performing macular surgeries. In has been observed that lutein and zeaxanthin dyes offer an intraoperative protective screen that protects photoreceptors more than Brilliant Blue while performing pars plana vitrectomy. Both study groups had good results in time. Surgical visualization is an evolving technology.

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