Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Vital dyes in macular hole surgery

  • Authors:
    • Ioana Stella (Patoni) Popescu
    • Ovidiu Mușat
    • Simona Stanca
    • Corina Cristina (Coman) Cernat
    • Cristina Patoni
    • Serban Negru
    • Adrian Teodoru
    • Horia Feier
    • Ciprian Danielescu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, ‘Victor Babeş’ University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania, Department of Ophthalmology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania, Department of Pediatrics, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Gastroenterology, ‘Dr. Carol Davila’ Central Military Emergency University Hospital, 010825 Bucharest, Romania, Department of Oncology, ‘Victor Babeş’ University of Medicine and Pharmacy Timisoara, 300239 Timisoara, Romania, Department of Ophthalmology, ‘Lucian Blaga’ University of Sibiu, 550169 Sibiu, Romania, Department of Cardiovascular Surgery, ‘Victor Babeş’ University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania, Department of Ophthalmology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
    Copyright: © Popescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 527
    |
    Published online on: March 22, 2021
       https://doi.org/10.3892/etm.2021.9959
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Currently, surgical techniques, such as internal limiting membrane peeling, are used widely for macular holes, macular puckers, epiretinal membranes, diabetic macular edema, retinal detachment, retinal vein occlusions, vitreomacular traction, optic pit maculopathy, and Terson syndrome. This study aimed to highlight any differences regarding visual acuity and ocular tomography coherence changes after staining the internal limiting membrane with dilutions of Brilliant Blue G vs. lutein/zeaxanthin‑based dyes. This study involved 30 eyes of 30 patients who had undergone posterior pole vitrectomy for idiopathic stage 4 macular hole. The study lot was divided in two subgroups, 15 eyes colored with Brilliant Blue and the other 15 eyes colored with lutein and zeaxanthin dyes. The association between visual prognosis, ocular tomography coherence changes and intraocular pressure was analyzed. The surgical treatment with required endoillumination levels and a 2‑min period of dye using the Alcon Constellation Vision System had no negative impact on cell viability and improved visual acuity by 30%. Staining makes it easier to remove, to be quick and precise while performing macular surgeries. In has been observed that lutein and zeaxanthin dyes offer an intraoperative protective screen that protects photoreceptors more than Brilliant Blue while performing pars plana vitrectomy. Both study groups had good results in time. Surgical visualization is an evolving technology.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Knapp H: About isolated ruptures of the choroid as a result of trauma to the eyeball. Arch Augenheilkd. 1:6–29. 1869.(In German).

2 

Noyes HD: Detachment of the retina with laceration at the macula. Trans Am Ophthalmol Soc. 1:128–129. 1871.PubMed/NCBI

3 

Bikbova G, Oshitari T, Baba T, Yamamoto S and Mori K: Pathogenesis and management of macular hole: Review of current advances. J Ophthalmol. 2019(3467381)2019.PubMed/NCBI View Article : Google Scholar

4 

Christensen UC: Value of internal limiting membrane peeling in surgery for idiopathic macular hole and the correlation between function and retinal morphology. Acta Ophthalmol. 87:1–23. 2009.PubMed/NCBI View Article : Google Scholar

5 

Almony A, Nudleman E, Shah GK, Blinder KJ, Eliott DB, Mittra RA and Tewari A: Techniques, rationale, and outcomes of internal limiting membrane peeling. Retina. 32:877–891. 2012.PubMed/NCBI View Article : Google Scholar

6 

Gelman R, Stevenson W, Prospero Ponce C, Agarwal D and Byron Christoforidis JB: Retinal damage induced by internal limiting membrane removal. J Ophthalmol. 2015(939748)2015.PubMed/NCBI View Article : Google Scholar

7 

Walia HS, Shah GK and Hariprasad SM: ILM peeling a vital intervention for many vitreoretinal disorders. Ophthalmic Surg Lasers Imaging Retina. 45:92–96. 2014.PubMed/NCBI View Article : Google Scholar

8 

Kelly NE and Wendel RT: Vitreous surgery for idiopathic macular holes: Results of a pilot study. Arch Ophthalmol. 109:654–659. 1991.PubMed/NCBI View Article : Google Scholar

9 

Morris R, Kuhn F and Witherspoon CD: Hemorrhagic macular cysts. Ophthalmology. 101(1)1994.PubMed/NCBI View Article : Google Scholar

10 

Lobeck E: Investigations into the role of retinal tear in skin detachment. Experimental investigations on the intraocular fluid change in artificial netskin detachment. Alb v. Graefes Arch Ophthalmol. 128:513–573. 1932.(In German).

11 

Abrams GW, Topping T and Machemer R: An improved method for practice vitrectomy. Arch Ophthalmol. 96:521–525. 1978.PubMed/NCBI View Article : Google Scholar

12 

Farah ME, Maia M and Rodrigues EB: Dyes in ocular surgery: Principles for use in chromovitrectomy. Am J Ophthalmol. 148:332–340. 2009.PubMed/NCBI View Article : Google Scholar

13 

Dubey AK: Trypan blue enhanced vitrectomy in clear gel vitrectomy. Indian J Ophthalmol. 51:286–287. 2003.PubMed/NCBI

14 

Peyman GA, Cheema R, Conway MD and Fang T: Triamcinolone acetonide as an aid to visualization of the vitreous and thre posteror hyaloid during pars plana vitrectomy. Retina. 20:554–555. 2000.PubMed/NCBI View Article : Google Scholar

15 

Neuman GO, Holbach H and Kruse FE: Applied Pathology for Ophthalmic Microsurgens. 5.6 Retina and Vitreous. Springer, pp300-301, 2008.

16 

Totan Y, Güler E and Dervişoğulları MS: Brilliant blue G assisted epiretinal membrane surgery. Sci Rep. 4(3956)2014.PubMed/NCBI View Article : Google Scholar

17 

Musat O, Stefan C, Boariu AM, Colta D, Cernat C, Alexandru L, Georgescu RD, Patoni IS, Timaru CM and De Algerino S: Chromovitrectomy. Rom J Ophthalmol. 60:59–62. 2016.PubMed/NCBI

18 

Preda MA, Popa G, Karancsi OL, Musat O, Popescu SI, Munteanu M and Popa Z: Effectiveness of subconjunctival bevacizumab associated with a laser-based procedure in the treatment of neovascular glaucoma. Farmacia. 66:621–626. 2018.

19 

Boruga O, Bălăşoiu AT, Giuri S, Munteanu M, Stanca HT, Iovănescu G and Preda MA: Caruncular late-onset junctional nevus: Apropos of an anatomo-clinical observation. Rom J Morphol Embryol. 58:1461–1464. 2017.PubMed/NCBI

20 

Balica NC, Poenaru M, Preda MA, Boia RE, Burlacu ON, Horhat ID, Mogoanță CA, Vlăescu AN, Baderca F, Jifcu EM and Sarău CA: Primary tonsillar tuberculosis-case report. Rom J Morphol Embryol. 60:267–271. 2019.PubMed/NCBI

21 

Popa G, Karancsi OL, Preda MA, Suta MC, Stelea L, Musat O, Popescu SI, Balica NC, Bogdanici C and Munteanu M: Assessment of Pain during laser-based procedures in the treatment of glaucoma. Rev Chim. 70:2105–2107. 2019.

22 

Preda MA, Karancsi OL, Munteanu M and Stanca HT: Clinical outcomes of micropulse transscleral cyclophotocoagulation in refractory glaucoma-18 months follow-up. Lasers Med Sci. 35:1487–1491. 2020.

23 

Stanca HT, Munteanu M, Jianu DC, Motoc AGM, Tăbăcaru B, Stanca S, Ungureanu E, Boruga VM and Preda MA: New perspectives in the use of laser diode transscleral cyclophotocoagulation. A prospective single center observational cohort study. Rom J Morphol Embryol. 59:869–872. 2018.PubMed/NCBI

24 

Stanca HT, Munteanu M, Jianu DC, Motoc AGM, Jecan CR, Tăbăcaru B, Stanca S and Preda MA: Femtosecond-LASIK outcomes using the. VisuMax®-MEL® 80 platform for mixed astigmatism refractive surgery, Rom J Morphol Embryol. 59:277–283. 2018.PubMed/NCBI

25 

Munteanu M, Rosca C and Stanca HT: Sub-inner limiting membrane hemorrhage in a patient with Terson syndrome. Int Ophthalmol. 39:461–464. 2019.PubMed/NCBI View Article : Google Scholar

26 

Brandão-Lencart J and Sousa-Martins D: New lutein-based dyes for ophthalmic surgery use. Kemin Inspired Molecular Solutions 2012. http://peschkemed.com/wp-content/uploads/2013/10/Retina-.pdf.

27 

Sousa-Martins D, Maia M, Moraes M, Lima-Filho AA, Rodrigues EB, Chen J, Farah ME, Santos LB and Belfort R Jr: Use of lutein and zeaxanthin alone or combined with Brilliant Blue to identify intraocular structures intraoperatively. Retina. 32:1328–1336. 2012.PubMed/NCBI View Article : Google Scholar

28 

Badaro E, Furlani B, Prazeres J, Maia M, Alves Souza Lima A, Souza-Martins D, Muccioli C, Adami Lucatto LF and Belfort R Jr: Soluble lutein in combination with brilliant blue as a new dye for chromovitrectomy. Graefes Arch Clin Exp Ophthalmol. 252:1071–1078. 2014.PubMed/NCBI View Article : Google Scholar

29 

Casaroli-Marano RP, Sousa-Martins D, Martínez-Conesa EM, Badaró E, Nunes RP, Lima-Filho AA, Rodrigues EB, Belfort R Jr and Maia M: Dye solutions based on lutein and zeaxanthin: In vitro and in vivo analysis of ocular toxicity profiles. Curr Eye Res. 40:707–718. 2014.PubMed/NCBI View Article : Google Scholar

30 

Maia M, Furlani BA, Souza-Lima AA, Martins DS, Navarro RM and Belfort R Jr: Lutein: A new dye for chromovitrectomy. Retina. 34:262–272. 2014.PubMed/NCBI View Article : Google Scholar

31 

Singh P, Deuchler S, Mueller M, Kohnen T, Sousa-Martins D, Pinheiro-Torres B and Koch FHJ: Chromovitrectomy with vitreodyne™. Invest Ophthalmol Vis Sci. 57(4452)2016.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Popescu IS, Mușat O, Stanca S, Cernat CC, Patoni C, Negru S, Teodoru A, Feier H and Danielescu C: Vital dyes in macular hole surgery. Exp Ther Med 21: 527, 2021.
APA
Popescu, I.S., Mușat, O., Stanca, S., Cernat, C.C., Patoni, C., Negru, S. ... Danielescu, C. (2021). Vital dyes in macular hole surgery. Experimental and Therapeutic Medicine, 21, 527. https://doi.org/10.3892/etm.2021.9959
MLA
Popescu, I. S., Mușat, O., Stanca, S., Cernat, C. C., Patoni, C., Negru, S., Teodoru, A., Feier, H., Danielescu, C."Vital dyes in macular hole surgery". Experimental and Therapeutic Medicine 21.5 (2021): 527.
Chicago
Popescu, I. S., Mușat, O., Stanca, S., Cernat, C. C., Patoni, C., Negru, S., Teodoru, A., Feier, H., Danielescu, C."Vital dyes in macular hole surgery". Experimental and Therapeutic Medicine 21, no. 5 (2021): 527. https://doi.org/10.3892/etm.2021.9959
Copy and paste a formatted citation
x
Spandidos Publications style
Popescu IS, Mușat O, Stanca S, Cernat CC, Patoni C, Negru S, Teodoru A, Feier H and Danielescu C: Vital dyes in macular hole surgery. Exp Ther Med 21: 527, 2021.
APA
Popescu, I.S., Mușat, O., Stanca, S., Cernat, C.C., Patoni, C., Negru, S. ... Danielescu, C. (2021). Vital dyes in macular hole surgery. Experimental and Therapeutic Medicine, 21, 527. https://doi.org/10.3892/etm.2021.9959
MLA
Popescu, I. S., Mușat, O., Stanca, S., Cernat, C. C., Patoni, C., Negru, S., Teodoru, A., Feier, H., Danielescu, C."Vital dyes in macular hole surgery". Experimental and Therapeutic Medicine 21.5 (2021): 527.
Chicago
Popescu, I. S., Mușat, O., Stanca, S., Cernat, C. C., Patoni, C., Negru, S., Teodoru, A., Feier, H., Danielescu, C."Vital dyes in macular hole surgery". Experimental and Therapeutic Medicine 21, no. 5 (2021): 527. https://doi.org/10.3892/etm.2021.9959
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team