Open Access

Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study

  • Authors:
    • Mircea Vasile Milaciu
    • Lorena Ciumărnean
    • Daniela Maria Matei
    • Ștefan Cristian Vesa
    • Octavia Sabin
    • Ioana Corina Bocșan
    • Raluca Maria Pop
    • Vasile Negrean
    • Anca Dana Buzoianu
    • Monica Acalovschi
  • View Affiliations

  • Published online on: March 23, 2021     https://doi.org/10.3892/etm.2021.9965
  • Article Number: 533
  • Copyright: © Milaciu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The aim of this study was to evaluate the possible association between paraoxonase‑1 (PON1), periostin (POSTN), tumor necrosis factor (TNF)‑α, interleukin (IL)‑6, IL‑10 serum concentration with non‑invasive liver fibrosis scores, in a cohort of patients with NAFLD. We studied a cohort of 52 patients diagnosed with NAFLD. The NAFLD fibrosis score (NFS), Fibrosis‑4 Index (FIB‑4), AST to platelet ratio index (APRI) and BARD scores were calculated for each patient. We determined the PON1, POSTN, TNF‑α, IL‑6, and IL‑10 serum values using ELISA kits. There was no correlation between PON1 or POSTN serum levels and non‑invasive liver fibrosis. The TNF‑α serum values were independently associated with the liver fibrosis scores (P=0.02 for NFS and P=0.002 for FIB‑4). Age and metabolic syndrome were also independently linked to the fibrosis scores. In conclusion, serum levels of TNF‑α, age and metabolic syndrome were associated with the non‑invasive liver fibrosis scores.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Milaciu MV, Ciumărnean L, Matei DM, Vesa ȘC, Sabin O, Bocșan IC, Pop RM, Negrean V, Buzoianu AD, Acalovschi M, Acalovschi M, et al: Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study. Exp Ther Med 21: 533, 2021
APA
Milaciu, M.V., Ciumărnean, L., Matei, D.M., Vesa, Ș.C., Sabin, O., Bocșan, I.C. ... Acalovschi, M. (2021). Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study. Experimental and Therapeutic Medicine, 21, 533. https://doi.org/10.3892/etm.2021.9965
MLA
Milaciu, M. V., Ciumărnean, L., Matei, D. M., Vesa, Ș. C., Sabin, O., Bocșan, I. C., Pop, R. M., Negrean, V., Buzoianu, A. D., Acalovschi, M."Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study". Experimental and Therapeutic Medicine 21.5 (2021): 533.
Chicago
Milaciu, M. V., Ciumărnean, L., Matei, D. M., Vesa, Ș. C., Sabin, O., Bocșan, I. C., Pop, R. M., Negrean, V., Buzoianu, A. D., Acalovschi, M."Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study". Experimental and Therapeutic Medicine 21, no. 5 (2021): 533. https://doi.org/10.3892/etm.2021.9965