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Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study

  • Authors:
    • Mircea Vasile Milaciu
    • Lorena Ciumărnean
    • Daniela Maria Matei
    • Ștefan Cristian Vesa
    • Octavia Sabin
    • Ioana Corina Bocșan
    • Raluca Maria Pop
    • Vasile Negrean
    • Anca Dana Buzoianu
    • Monica Acalovschi
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    Affiliations: Department 5‑Internal Medicine, 4th Medical Clinic, Faculty of Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400015 Cluj‑Napoca, Romania, Department 5‑Internal Medicine, 3rd Medical Clinic, Faculty of Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400162 Cluj‑Napoca, Romania, Department 2‑Functional Sciences, Discipline of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400337 Cluj‑Napoca, Romania, Doctoral School, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania
    Copyright: © Milaciu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 533
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    Published online on: March 23, 2021
       https://doi.org/10.3892/etm.2021.9965
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Abstract

Non‑alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The aim of this study was to evaluate the possible association between paraoxonase‑1 (PON1), periostin (POSTN), tumor necrosis factor (TNF)‑α, interleukin (IL)‑6, IL‑10 serum concentration with non‑invasive liver fibrosis scores, in a cohort of patients with NAFLD. We studied a cohort of 52 patients diagnosed with NAFLD. The NAFLD fibrosis score (NFS), Fibrosis‑4 Index (FIB‑4), AST to platelet ratio index (APRI) and BARD scores were calculated for each patient. We determined the PON1, POSTN, TNF‑α, IL‑6, and IL‑10 serum values using ELISA kits. There was no correlation between PON1 or POSTN serum levels and non‑invasive liver fibrosis. The TNF‑α serum values were independently associated with the liver fibrosis scores (P=0.02 for NFS and P=0.002 for FIB‑4). Age and metabolic syndrome were also independently linked to the fibrosis scores. In conclusion, serum levels of TNF‑α, age and metabolic syndrome were associated with the non‑invasive liver fibrosis scores.
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Copy and paste a formatted citation
Spandidos Publications style
Milaciu MV, Ciumărnean L, Matei DM, Vesa ȘC, Sabin O, Bocșan IC, Pop RM, Negrean V, Buzoianu AD, Acalovschi M, Acalovschi M, et al: Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study. Exp Ther Med 21: 533, 2021.
APA
Milaciu, M.V., Ciumărnean, L., Matei, D.M., Vesa, Ș.C., Sabin, O., Bocșan, I.C. ... Acalovschi, M. (2021). Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study. Experimental and Therapeutic Medicine, 21, 533. https://doi.org/10.3892/etm.2021.9965
MLA
Milaciu, M. V., Ciumărnean, L., Matei, D. M., Vesa, Ș. C., Sabin, O., Bocșan, I. C., Pop, R. M., Negrean, V., Buzoianu, A. D., Acalovschi, M."Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study". Experimental and Therapeutic Medicine 21.5 (2021): 533.
Chicago
Milaciu, M. V., Ciumărnean, L., Matei, D. M., Vesa, Ș. C., Sabin, O., Bocșan, I. C., Pop, R. M., Negrean, V., Buzoianu, A. D., Acalovschi, M."Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study". Experimental and Therapeutic Medicine 21, no. 5 (2021): 533. https://doi.org/10.3892/etm.2021.9965
Copy and paste a formatted citation
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Spandidos Publications style
Milaciu MV, Ciumărnean L, Matei DM, Vesa ȘC, Sabin O, Bocșan IC, Pop RM, Negrean V, Buzoianu AD, Acalovschi M, Acalovschi M, et al: Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study. Exp Ther Med 21: 533, 2021.
APA
Milaciu, M.V., Ciumărnean, L., Matei, D.M., Vesa, Ș.C., Sabin, O., Bocșan, I.C. ... Acalovschi, M. (2021). Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study. Experimental and Therapeutic Medicine, 21, 533. https://doi.org/10.3892/etm.2021.9965
MLA
Milaciu, M. V., Ciumărnean, L., Matei, D. M., Vesa, Ș. C., Sabin, O., Bocșan, I. C., Pop, R. M., Negrean, V., Buzoianu, A. D., Acalovschi, M."Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study". Experimental and Therapeutic Medicine 21.5 (2021): 533.
Chicago
Milaciu, M. V., Ciumărnean, L., Matei, D. M., Vesa, Ș. C., Sabin, O., Bocșan, I. C., Pop, R. M., Negrean, V., Buzoianu, A. D., Acalovschi, M."Cytokines, paraoxonase‑1, periostin and non‑invasive liver fibrosis scores in patients with non‑alcoholic fatty liver disease and persistently elevated aminotransferases: A pilot study". Experimental and Therapeutic Medicine 21, no. 5 (2021): 533. https://doi.org/10.3892/etm.2021.9965
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