Teratogenic effect of isotretinoin in both fertile females and males (Review)

  • Authors:
    • Carmen-Cristina Draghici
    • Raluca-Gabriela Miulescu
    • Răzvan-Cosmin Petca
    • Aida Petca
    • Mihai Cristian Dumitrașcu
    • Florica Șandru
  • View Affiliations

  • Published online on: March 23, 2021     https://doi.org/10.3892/etm.2021.9966
  • Article Number: 534
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Isotretinoin is an oral derivate of vitamin A that has been used since 1982 for the treatment of multiple dermatologic conditions such as severe acne, rosacea, scarring alopecia, ichthyosis or non‑melanoma skin cancer prophylaxis. The recommended dose is 0.5‑1 mg/kg/day for a period of 4‑6 months in sebaceous gland pathologies. There are many adverse effects caused by isotretinoin but by far the most important is the teratogenicity induced by this drug which is estimated to have a 20‑35% risk to infants that are exposed to isotretinoin in utero and includes numerous congenital defects such as craniofacial defects, cardiovascular and neurological malformations or thymic disorders. Isotretinoin induces apoptosis and cell cycle arrest in human sebocytes, emphasizing these as processes associated with its teratogenic effect. The aim of this review is to analyze the latest literature data regarding the teratogenic effect of isotretinoin for both fertile females and males and its biological effects underlying the occurrence of congenital malformations under the influence of isotretinoin.
View References

Related Articles

Journal Cover

May-2021
Volume 21 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Draghici C, Miulescu R, Petca R, Petca A, Dumitrașcu MC and Șandru F: Teratogenic effect of isotretinoin in both fertile females and males (Review). Exp Ther Med 21: 534, 2021
APA
Draghici, C., Miulescu, R., Petca, R., Petca, A., Dumitrașcu, M.C., & Șandru, F. (2021). Teratogenic effect of isotretinoin in both fertile females and males (Review). Experimental and Therapeutic Medicine, 21, 534. https://doi.org/10.3892/etm.2021.9966
MLA
Draghici, C., Miulescu, R., Petca, R., Petca, A., Dumitrașcu, M. C., Șandru, F."Teratogenic effect of isotretinoin in both fertile females and males (Review)". Experimental and Therapeutic Medicine 21.5 (2021): 534.
Chicago
Draghici, C., Miulescu, R., Petca, R., Petca, A., Dumitrașcu, M. C., Șandru, F."Teratogenic effect of isotretinoin in both fertile females and males (Review)". Experimental and Therapeutic Medicine 21, no. 5 (2021): 534. https://doi.org/10.3892/etm.2021.9966