Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 21 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature

  • Authors:
    • Sorina Maria Taban
    • Robert Alexandru Barna
    • Alis Liliana Carmen Dema
    • Iulia Maria Ratiu
    • Oana Popa
    • Andrei Dorel Plopeanu
  • View Affiliations / Copyright

    Affiliations: Department of Microscopic Morphology‑Morphopathology, ‘Victor Babeș’ University of Medicine and Pharmacy, Timisoara, 300041 Timisoara, Romania, Department of Internal Medicine II, Discipline of Gastroenterology and Hepatology, ‘Victor Babeș’ University of Medicine and Pharmacy, Timisoara, 300041 Timisoara, Romania, Anatomic Pathology Service, ‘Pius Brînzeu’ County Emergency Clinical Hospital, 300723 Timisoara, Romania
    Copyright: © Taban et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 536
    |
    Published online on: March 23, 2021
       https://doi.org/10.3892/etm.2021.9968
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A granular cell tumor (GCT) is a rare neoplasia that originates from Schwann cells. It usually appears in the skin or soft tissues, but it may occur anywhere in the body. The gastrointestinal tract is an unusual developmental site for a GCT, the esophagus being the most common site of origin for this tumor. The stomach is one of the most unique sites of origin for GCT, with less than 80 cases being mentioned in the literature. Histologically, GCTs consist of fusiform and polygonal cells, with granular cytoplasm, arranged in compact ‘nests’. Immunohistochemically, these tumors show positivity for S100 protein, CD68, CD56 and, in a smaller percentage, they are positive for other antibodies, most notably inhibin alpha. We report the case of a 52‑year‑old woman with a solitary GCT that had developed in the gastric cardia, discovered on a routine gastroscopy and successfully treated by endoscopic submucosal dissection.
View Figures

Figure 1

View References

1 

Weber CO: Anatomical examination of a hypertrophic tongue along with remarks on the formation of striated muscle fibers. Virchows Arch A Pathol Anat. 7:115–125. 1854.(In German).

2 

Abrikossoff A: Concerning myomas starting from the striated voluntary musculature. Virchows Arch Pathol Anat. 260:215–233. 1926.(In German).

3 

Kim DJ, Kim HW, Park SB, Choi CW, Kang DH, Hong JB, Ji BH and Lee CS: A case of gastric granular cell tumor: Review of literature and features of endoscopic ultrasonography. Korean J Helicobacter Up Gastrointest Res. 15(59)2015.

4 

Fisher ER and Wechsler H: Granular cell myoblastoma-a misnomer. Electron microscopic and histochemical evidence concerning its schwann cell derivation and nature (granular cell schwannoma). Cancer. 15:936–954. 1962.PubMed/NCBI View Article : Google Scholar

5 

Mazur MT, Shultz JJ and Myers JL: Granular cell tumor. Immunohistochemical analysis of 21 benign tumors and one malignant tumor. Arch Pathol Lab Med. 114:692–696. 1990.PubMed/NCBI

6 

Lack EE, Worsham RGF, Callihan MD, Crawford BE, Klappenbach S, Rowden G and Chun B: Granular cell tumor: A clinicopathologic study of 110 patients. J Surg Oncol. 13:301–316. 1980.PubMed/NCBI View Article : Google Scholar

7 

Johnston MJ and Helwig EB: Granular cell tumors of the gastrointestinal tract and perianal region A study of 74 cases. Dig Dis Sci. 26:807–816. 1981.PubMed/NCBI View Article : Google Scholar

8 

Yasuda A, Yasuda T, Imamoto H, Hiraki Y, Momose K, Kato H, Iwama M, Shiraishi O, Shinkai M, Imano M, et al: A case of a gastric granular cell tumor preoperatively diagnosed and successfully treated by single-incision laparoscopic surgery. Surg Case Rep. 6(44)2020.PubMed/NCBI View Article : Google Scholar

9 

Barakat M, Kar AA, Pourshahid S, Ainechi S, Lee HJ, Othman M and Tadros M: Gastrointestinal and biliary granular cell tumor: Diagnosis and management. Ann Gastroenterol. 31:439–447. 2018.PubMed/NCBI View Article : Google Scholar

10 

Patti R, Almasio PL and Di Vita G: Granular cell tumor of stomach: A case report and review of literature. World J Gastroenterol. 12:3442–3445. 2006.PubMed/NCBI View Article : Google Scholar

11 

An S, Jang J, Min K, Kim MS, Park H, Park YS, Kim J, Lee JH, Song HJ, Kim KJ, et al: Granular cell tumor of the gastrointestinal tract: Histologic and immunohistochemical analysis of 98 cases. Hum Pathol. 46:813–819. 2015.PubMed/NCBI View Article : Google Scholar

12 

Lazar AJF and Fletcher CDM: Primitive nonneural granular cell tumors of skin: Clinicopathologic analysis of 13 cases. Am J Surg Pathol. 29:927–934. 2005.PubMed/NCBI View Article : Google Scholar

13 

Vered M, Carpenter WM and Buchner A: Granular cell tumor of the oral cavity: Updated immunohistochemical profile. J Oral Pathol Med. 38:150–159. 2009.PubMed/NCBI View Article : Google Scholar

14 

Fine SW and Li M: Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. Am J Clin Pathol. 119:259–264. 2003.PubMed/NCBI View Article : Google Scholar

15 

Parfitt JR, McLean CA, Joseph MG, Streutker CJ, Al-Haddad S and Driman DK: Granular cell tumours of the gastrointestinal tract: Expression of nestin and clinicopathological evaluation of 11 patients. Histopathology. 48:424–430. 2006.PubMed/NCBI View Article : Google Scholar

16 

Fanburg-Smith JC, Meis-Kindblom JM, Fante R and Kindblom LG: Malignant granular cell tumor of soft tissue: Diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 22:779–794. 1998.PubMed/NCBI View Article : Google Scholar

17 

Lu W, Xu MD, Zhou PH, Zhang YQ, Chen WF, Zhong YS and Yao LQ: Endoscopic submucosal dissection of esophageal granular cell tumor. World J Surg Oncol. 12(221)2014.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Taban SM, Barna RA, Dema AL, Ratiu IM, Popa O and Plopeanu AD: Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature. Exp Ther Med 21: 536, 2021.
APA
Taban, S.M., Barna, R.A., Dema, A.L., Ratiu, I.M., Popa, O., & Plopeanu, A.D. (2021). Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature. Experimental and Therapeutic Medicine, 21, 536. https://doi.org/10.3892/etm.2021.9968
MLA
Taban, S. M., Barna, R. A., Dema, A. L., Ratiu, I. M., Popa, O., Plopeanu, A. D."Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature". Experimental and Therapeutic Medicine 21.5 (2021): 536.
Chicago
Taban, S. M., Barna, R. A., Dema, A. L., Ratiu, I. M., Popa, O., Plopeanu, A. D."Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature". Experimental and Therapeutic Medicine 21, no. 5 (2021): 536. https://doi.org/10.3892/etm.2021.9968
Copy and paste a formatted citation
x
Spandidos Publications style
Taban SM, Barna RA, Dema AL, Ratiu IM, Popa O and Plopeanu AD: Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature. Exp Ther Med 21: 536, 2021.
APA
Taban, S.M., Barna, R.A., Dema, A.L., Ratiu, I.M., Popa, O., & Plopeanu, A.D. (2021). Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature. Experimental and Therapeutic Medicine, 21, 536. https://doi.org/10.3892/etm.2021.9968
MLA
Taban, S. M., Barna, R. A., Dema, A. L., Ratiu, I. M., Popa, O., Plopeanu, A. D."Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature". Experimental and Therapeutic Medicine 21.5 (2021): 536.
Chicago
Taban, S. M., Barna, R. A., Dema, A. L., Ratiu, I. M., Popa, O., Plopeanu, A. D."Unexpected diagnosis for a gastric polyp: Granular cell tumor: Case report and review of the literature". Experimental and Therapeutic Medicine 21, no. 5 (2021): 536. https://doi.org/10.3892/etm.2021.9968
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team