Circulating IL‑37 levels are elevated in patients with hypertension

  • Authors:
    • Jing Ye
    • Yuan Wang
    • Zhen Wang
    • Yingzhong Lin
    • Ling Liu
    • Qi Zhou
    • Menglong Wang
    • Yao Xu
    • Di Ye
    • Jishou Zhang
    • Jun Wan
    • Qingwei Ji
  • View Affiliations

  • Published online on: March 26, 2021     https://doi.org/10.3892/etm.2021.9990
  • Article Number: 558
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Abstract

Interleukin‑37 (IL‑37) has been reported to be closely linked to vascular diseases, including atherosclerosis and aortic calcification. The present study aimed to assess the expression levels of IL‑37 in patients with hypertension. Blood samples were collected from control subjects (n=20) and patients with hypertension (n=45). Subsequently, macrophages, lymphocytes and dendritic cells were individually isolated and the mRNA expression of IL‑37 was measured. In addition, the circulating IL‑37 levels in control subjects (n=30) and patients with hypertension (n=334) were assessed. Furthermore, all patients who were subjected to detection of circulating IL‑37 underwent ambulatory blood pressure monitoring. The results suggested that the mRNA levels of IL‑37 in macrophages, but not in lymphocytes and dendritic cells, isolated from patients with hypertension were markedly elevated compared with those in cells isolated from control subjects. Circulating IL‑37 levels were increased in patients with hypertension compared with those in control subjects and positively correlated with systolic and diastolic blood pressure in patients with hypertension. No differences were observed between patients with dipper hypertension and patients with non‑dipper hypertension. In addition, patients with hypertension with a smoking habit, type 2 diabetes mellitus and carotid atherosclerotic plaque (CAP) exhibited higher IL‑37 levels. IL‑37 levels were positively correlated with creatinine, C‑reactive protein and homocysteine levels. Furthermore, the results of a linear regression analysis suggested that IL‑37 levels were independently associated with the presence of CAP. In conclusion, IL‑37 levels are increased in patients with hypertension and may be associated with the onset of CAP.
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June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Ye J, Wang Y, Wang Z, Lin Y, Liu L, Zhou Q, Wang M, Xu Y, Ye D, Zhang J, Zhang J, et al: Circulating IL‑37 levels are elevated in patients with hypertension. Exp Ther Med 21: 558, 2021
APA
Ye, J., Wang, Y., Wang, Z., Lin, Y., Liu, L., Zhou, Q. ... Ji, Q. (2021). Circulating IL‑37 levels are elevated in patients with hypertension. Experimental and Therapeutic Medicine, 21, 558. https://doi.org/10.3892/etm.2021.9990
MLA
Ye, J., Wang, Y., Wang, Z., Lin, Y., Liu, L., Zhou, Q., Wang, M., Xu, Y., Ye, D., Zhang, J., Wan, J., Ji, Q."Circulating IL‑37 levels are elevated in patients with hypertension". Experimental and Therapeutic Medicine 21.6 (2021): 558.
Chicago
Ye, J., Wang, Y., Wang, Z., Lin, Y., Liu, L., Zhou, Q., Wang, M., Xu, Y., Ye, D., Zhang, J., Wan, J., Ji, Q."Circulating IL‑37 levels are elevated in patients with hypertension". Experimental and Therapeutic Medicine 21, no. 6 (2021): 558. https://doi.org/10.3892/etm.2021.9990