Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus

  • Authors:
    • Yan Kang
    • Huamin Huang
    • Haipeng Li
    • Wenping Sun
    • Cuicui Zhang
  • View Affiliations

  • Published online on: March 26, 2021     https://doi.org/10.3892/etm.2021.9994
  • Article Number: 562
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A previous study revealed that protein tyrosine phosphatase receptor type D (PTPRD) is highly associated with diabetes mellitus, particularly for type 2 diabetes, through a genome‑wide association study. However, the influence of the human polymorphism in the 3'‑untranslated region (3'‑UTR) of PTPRD on gestational diabetes mellitus (GDM) has remained to be defined. The present study focused on the functional polymorphism located in the 3'‑UTR of PTPRD and whether it is associated with the susceptibility to develop GDM. A total of 1,100 pregnant female patients aged between 28 and 36 years within gestational weeks 24‑28 were recruited. The participants enrolled in the study comprised 500 cases of GDM and 600 normal controls. Based on the screening results, the single nucleotide polymorphism (SNP) rs56407701 exhibited the most significant difference and may increase the susceptibility to GDM. A prediction of target microRNAs (miRNAs/miRs) using the miRNA SNP database indicated that SNP rs56407701 may be bound by miR‑450a, causing the suppression of PTPRD expression in subjects with the GC or CC genotype. In conclusion, The CC genotype of PTPRD rs56407701, which may be bound by miR‑450a, may increase the susceptibility of Chinese Han females to GDM during pregnancy. The present study provided a theoretical basis for the SNP rs56407701 being a source of GDM susceptibility loci.
View Figures
View References

Related Articles

Journal Cover

June-2021
Volume 21 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kang Y, Huang H, Li H, Sun W and Zhang C: Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus. Exp Ther Med 21: 562, 2021
APA
Kang, Y., Huang, H., Li, H., Sun, W., & Zhang, C. (2021). Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus. Experimental and Therapeutic Medicine, 21, 562. https://doi.org/10.3892/etm.2021.9994
MLA
Kang, Y., Huang, H., Li, H., Sun, W., Zhang, C."Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus". Experimental and Therapeutic Medicine 21.6 (2021): 562.
Chicago
Kang, Y., Huang, H., Li, H., Sun, W., Zhang, C."Functional genetic variants in the 3'UTR of PTPRD associated with the risk of gestational diabetes mellitus". Experimental and Therapeutic Medicine 21, no. 6 (2021): 562. https://doi.org/10.3892/etm.2021.9994