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Case Report Open Access

From chronic pruritus to neuroendocrine tumor: A case report

  • Authors:
    • Alexandr Ceasovschih
    • Giorgiana Voloc
    • Victorița Șorodoc
    • Dan Vâță
    • Cristian-Dumitru Lupașcu
    • Cristina Preda
    • Cătălina Lionte
    • Alexandra Stoica
    • Oana Sîrbu
    • Elena-Daniela Grigorescu
    • Raluca Ecaterina Haliga
    • Adorata Elena Coman
    • Cristina Bologa
    • Luminița Gina Vâță
    • Ovidiu Rusalim Petriș
    • Gabriela Puha
    • Gabriela Dumitrescu
    • Mihai Constantin
    • Laurențiu Șorodoc

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Internal Medicine, ‘Sf. Spiridon’ Clinical Emergency Hospital, 700111 Iasi, Romania
    Copyright: © Ceasovschih et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 189
    |
    Published online on: January 4, 2022
       https://doi.org/10.3892/etm.2022.11112
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Abstract

Chronic pruritus is a major and distressing symptom of many diseases of dermatological, neurological, psychogenic or systemic origin. This chronic itch could be a presenting sign of malignancy; therefore, paraneoplastic pruritus has also been associated with neuroendocrine tumors (NETs). This article focuses on a patient presenting with chronic pruritus for the past 12 months and who received numerous treatment schemes with very poor clinical improvement, that presented in the hospital for worsening of the chronic pruritus associated with skin rash and significant weight loss (approximately 6 kg over a 2‑month period). The laboratory tests showed iron deficiency anemia, eosinophilia and negative tumor markers. In order to investigate the hypoanabolic and anemic syndromes, upper gastrointestinal endoscopy and colonoscopy, which showed no lesions or tumors, were employed. Skin biopsy was performed and antihistaminic and local steroid treatment was initiated. The patient's status worsened within a week and the patient was started on systemic steroid treatment with poor results. Computer tomography was performed to identify any tumor(s) located either in the pelvis or abdomen. A lesion was found in the terminal ileum, identified as a hypervascularized associating bulky lymphadenopathy. The patient was transferred to the surgical ward where right hemicolectomy with manual ileotransverse anastomosis L‑L was performed. The histopathological result confirmed NET G2. The patient clinically improved, the skin lesions resolved and the itchiness disappeared. The general status improved significantly. NET G2 diagnosing was possible due to the atypic paraneoplastic sign: chronic pruritus. This case study highlights the association between itch and malignancy and presents an atypical way of NET presentation when all tumor markers remain negative.
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Copy and paste a formatted citation
Spandidos Publications style
Ceasovschih A, Voloc G, Șorodoc V, Vâță D, Lupașcu C, Preda C, Lionte C, Stoica A, Sîrbu O, Grigorescu E, Grigorescu E, et al: From chronic pruritus to neuroendocrine tumor: A case report. Exp Ther Med 23: 189, 2022.
APA
Ceasovschih, A., Voloc, G., Șorodoc, V., Vâță, D., Lupașcu, C., Preda, C. ... Șorodoc, L. (2022). From chronic pruritus to neuroendocrine tumor: A case report. Experimental and Therapeutic Medicine, 23, 189. https://doi.org/10.3892/etm.2022.11112
MLA
Ceasovschih, A., Voloc, G., Șorodoc, V., Vâță, D., Lupașcu, C., Preda, C., Lionte, C., Stoica, A., Sîrbu, O., Grigorescu, E., Haliga, R. E., Coman, A. E., Bologa, C., Vâță, L. G., Petriș, O. R., Puha, G., Dumitrescu, G., Constantin, M., Șorodoc, L."From chronic pruritus to neuroendocrine tumor: A case report". Experimental and Therapeutic Medicine 23.3 (2022): 189.
Chicago
Ceasovschih, A., Voloc, G., Șorodoc, V., Vâță, D., Lupașcu, C., Preda, C., Lionte, C., Stoica, A., Sîrbu, O., Grigorescu, E., Haliga, R. E., Coman, A. E., Bologa, C., Vâță, L. G., Petriș, O. R., Puha, G., Dumitrescu, G., Constantin, M., Șorodoc, L."From chronic pruritus to neuroendocrine tumor: A case report". Experimental and Therapeutic Medicine 23, no. 3 (2022): 189. https://doi.org/10.3892/etm.2022.11112
Copy and paste a formatted citation
x
Spandidos Publications style
Ceasovschih A, Voloc G, Șorodoc V, Vâță D, Lupașcu C, Preda C, Lionte C, Stoica A, Sîrbu O, Grigorescu E, Grigorescu E, et al: From chronic pruritus to neuroendocrine tumor: A case report. Exp Ther Med 23: 189, 2022.
APA
Ceasovschih, A., Voloc, G., Șorodoc, V., Vâță, D., Lupașcu, C., Preda, C. ... Șorodoc, L. (2022). From chronic pruritus to neuroendocrine tumor: A case report. Experimental and Therapeutic Medicine, 23, 189. https://doi.org/10.3892/etm.2022.11112
MLA
Ceasovschih, A., Voloc, G., Șorodoc, V., Vâță, D., Lupașcu, C., Preda, C., Lionte, C., Stoica, A., Sîrbu, O., Grigorescu, E., Haliga, R. E., Coman, A. E., Bologa, C., Vâță, L. G., Petriș, O. R., Puha, G., Dumitrescu, G., Constantin, M., Șorodoc, L."From chronic pruritus to neuroendocrine tumor: A case report". Experimental and Therapeutic Medicine 23.3 (2022): 189.
Chicago
Ceasovschih, A., Voloc, G., Șorodoc, V., Vâță, D., Lupașcu, C., Preda, C., Lionte, C., Stoica, A., Sîrbu, O., Grigorescu, E., Haliga, R. E., Coman, A. E., Bologa, C., Vâță, L. G., Petriș, O. R., Puha, G., Dumitrescu, G., Constantin, M., Șorodoc, L."From chronic pruritus to neuroendocrine tumor: A case report". Experimental and Therapeutic Medicine 23, no. 3 (2022): 189. https://doi.org/10.3892/etm.2022.11112
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