Open Access

Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review)

  • Authors:
    • Vlad Pădureanu
    • Dan Nicolae Florescu
    • Rodica Pădureanu
    • Alice Elena Ghenea
    • Dan Ionuț Gheonea
    • Carmen Nicoleta Oancea
  • View Affiliations

  • Published online on: January 5, 2022     https://doi.org/10.3892/etm.2022.11120
  • Article Number: 197
  • Copyright: © Pădureanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute pancreatitis (AP) is a severe disease with a high prevalence and 3 to 15% mortality worldwide, which can represent an important challenge for the physician. Oxidative stress and antioxidants are involved in AP progression. The mechanisms responsible for the onset and progression of AP are still poorly understood. Previous studies have highlighted the important contribution of antioxidants and oxidative stress in AP. The existence of a relationship between oxidative stress and antioxidants in AP is unquestionable, although a more accurate understanding of the mechanistic pathways involved is required to create a solid basis for potential prevention or treatment strategies. Further investigation is needed to clarify the role of antioxidant status and the severity of AP and to determine the association between oxidative stress and pancreatic enzyme activities. Antioxidant therapy may represent an interesting option for the management of patients with AP, although additional information about the effectiveness of this potential treatment is required.
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March-2022
Volume 23 Issue 3

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Spandidos Publications style
Pădureanu V, Florescu DN, Pădureanu R, Ghenea AE, Gheonea DI and Oancea CN: Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review). Exp Ther Med 23: 197, 2022
APA
Pădureanu, V., Florescu, D.N., Pădureanu, R., Ghenea, A.E., Gheonea, D.I., & Oancea, C.N. (2022). Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review). Experimental and Therapeutic Medicine, 23, 197. https://doi.org/10.3892/etm.2022.11120
MLA
Pădureanu, V., Florescu, D. N., Pădureanu, R., Ghenea, A. E., Gheonea, D. I., Oancea, C. N."Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review)". Experimental and Therapeutic Medicine 23.3 (2022): 197.
Chicago
Pădureanu, V., Florescu, D. N., Pădureanu, R., Ghenea, A. E., Gheonea, D. I., Oancea, C. N."Role of antioxidants and oxidative stress in the evolution of acute pancreatitis (Review)". Experimental and Therapeutic Medicine 23, no. 3 (2022): 197. https://doi.org/10.3892/etm.2022.11120