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Case Report Open Access

Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature

  • Authors:
    • Gabriela Mariana Iancu
    • Dan Mircea Stănilă
    • Remus Călin Cipăian
    • Maria Rotaru
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania, Department of Ophthalmology, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania, Department of Internal Medicine, Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania
    Copyright: © Iancu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 214
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    Published online on: January 11, 2022
       https://doi.org/10.3892/etm.2022.11138
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Abstract

The increasing incidence for herpes zoster, including its ophthalmic form, is based on physiological (senescence) and acquired immunosuppression, particularly under oncologic treatment. The immunocompromised status of the patient favors the appearance of severe complications. The patient, aged 54, with chronic lymphocytic leukemia, presented 1 week from the onset with an erythematous, vesicular‑bullous rash on the right trigeminal nerveʼs ophthalmic dermatome, marked edema, intense pain and large submandibular ganglion masses. There were cutaneous (necrotic ulcerations superinfected with methicillin‑resistant Staphylococcus aureus), ocular (keratoconjunctivitis, total ophthalmoplegia, lagophthalmia, anterior hemorrhagic uveitis with hyphema and right eye blindness) and neurological (postherpetic neuralgia) complications. Systemic therapy was performed with acyclovir, antibiotics, supportive, rebalancing and symptomatics. With regards to treatment for skin ulcers, disinfection and necrectomy were performed, and epithelialization agents were subsequently administrated. At the ocular level, the ophthalmologist carefully monitored the patient and administered antivirals, antibiotics, epithelialization agents and autologous serum. The evolution of the case recorded severe, disabling complications, with extensive eyelid necrosis and definitive blindness. In this case, the severity of the ophthalmic herpes zoster (OHZ) was favored by the synergistic action of four factors: Acquired immunosuppression (chronic lymphocytic leukemia), delayed consultation, superinfectious lesions and patient non‑compliance regarding the chronic lymphocytic leukemia treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Iancu GM, Stănilă DM, Cipăian RC and Rotaru M: Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature. Exp Ther Med 23: 214, 2022.
APA
Iancu, G.M., Stănilă, D.M., Cipăian, R.C., & Rotaru, M. (2022). Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature. Experimental and Therapeutic Medicine, 23, 214. https://doi.org/10.3892/etm.2022.11138
MLA
Iancu, G. M., Stănilă, D. M., Cipăian, R. C., Rotaru, M."Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature". Experimental and Therapeutic Medicine 23.3 (2022): 214.
Chicago
Iancu, G. M., Stănilă, D. M., Cipăian, R. C., Rotaru, M."Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature". Experimental and Therapeutic Medicine 23, no. 3 (2022): 214. https://doi.org/10.3892/etm.2022.11138
Copy and paste a formatted citation
x
Spandidos Publications style
Iancu GM, Stănilă DM, Cipăian RC and Rotaru M: Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature. Exp Ther Med 23: 214, 2022.
APA
Iancu, G.M., Stănilă, D.M., Cipăian, R.C., & Rotaru, M. (2022). Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature. Experimental and Therapeutic Medicine, 23, 214. https://doi.org/10.3892/etm.2022.11138
MLA
Iancu, G. M., Stănilă, D. M., Cipăian, R. C., Rotaru, M."Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature". Experimental and Therapeutic Medicine 23.3 (2022): 214.
Chicago
Iancu, G. M., Stănilă, D. M., Cipăian, R. C., Rotaru, M."Ophthalmic herpes zoster with severe complications in an immunocompromised patient: A case report and review of the literature". Experimental and Therapeutic Medicine 23, no. 3 (2022): 214. https://doi.org/10.3892/etm.2022.11138
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