Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2022 Volume 23 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2022 Volume 23 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats

  • Authors:
    • Qian Liu
    • Ruoyi Wang
    • Nan Ma
    • Chuntian Wang
    • Weixiu Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 216
    |
    Published online on: January 11, 2022
       https://doi.org/10.3892/etm.2022.11140
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hypertension is associated with bladder symptoms. The present study investigated whether an angiotensin receptor blocker could improve the symptoms and pathological changes associated with a neurogenic bladder (NB). A Sprague‑Dawley rat model of NB was constructed. Rats in the sham and model groups were gavaged with saline, and rats in the treatment group were gavaged with telmisartan. Urodynamic parameters, including maximum cystometric capacity, residual urine volume, bladder wet weight, bladder compliance and detrusor pressure, were detected. Masson and H&E staining were performed to assess bladder fibrosis and histopathological changes. The expression levels of basic fibroblast growth factor (bFGF), TGF‑β1, Collagen I, Collagen III, and α‑smooth muscle actin (α‑SMA) were also measured by reverse transcription‑quantitative PCR, western blotting and immunohistochemistry. The model rats exhibited symptoms and pathological changes associated with NB. Treatment with telmisartan reduced maximum cystometric capacity, residual urine volume, bladder compliance and bladder wet weight, and increased detrusor pressure in model rats. The tissue staining results showed that telmisartan exerted an antifibrotic effect. In addition, telmisartan inhibited the expression of bFGF, TGF‑β1, Collagen I, Collagen III and α‑SMA in model rats. Therefore, the results of the present study indicated that telmisartan may serve as a potential therapeutic agent for NB.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M and Del Popolo G: Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury. World J Urol. 36:1517–1527. 2018.PubMed/NCBI View Article : Google Scholar

2 

Przydacz M, Chlosta P and Corcos J: Recommendations for urological follow-up of patients with neurogenic bladder secondary to spinal cord injury. Int Urol Nephrol. 50:1005–1016. 2018.PubMed/NCBI View Article : Google Scholar

3 

Shang Z, Jia C, Yan H, Cui B, Wu J, Wang Q, Gao W, Cui X, Li J and Ou T: Injecting RNA interference lentiviruses targeting the muscarinic 3 receptor gene into the bladder wall inhibits neurogenic detrusor overactivity in rats with spinal cord injury. Neurourol Urodyn. 38:615–624. 2019.PubMed/NCBI View Article : Google Scholar

4 

Ge Q, Wang M, Lin Y, Xu C, Xiao J and Shen Z: Establishment of animal model manifested as bladder neurogenic changes generated by bilateral pelvic nerve injury in male rats. Int Urol Nephrol. 53:421–429. 2021.PubMed/NCBI View Article : Google Scholar

5 

Doyle C, Cristofaro V, Sack BS, Mahmood F, Sullivan MP and Adam RM: The role of the mucosa in modulation of evoked responses in the spinal cord injured rat bladder. Neurourol Urodyn. 37:1583–1593. 2018.PubMed/NCBI View Article : Google Scholar

6 

Soebadi MA, Bakula M, Hakim L, Puers R and De Ridder D: Wireless intravesical device for real-time bladder pressure measurement: Study of consecutive voiding in awake minipigs. PLoS One. 14(e0225821)2019.PubMed/NCBI View Article : Google Scholar

7 

Wyndaele JJ, Birch B, Borau A, Burks F, Castro-Diaz D, Chartier-Kastler E, Drake M, Ishizuka O, Minigawa T, Opisso E, et al: Surgical management of the neurogenic bladder after spinal cord injury. World J Urol. 36:1569–1576. 2018.PubMed/NCBI View Article : Google Scholar

8 

Romo PGB, Smith CP, Cox A, Averbeck MA, Dowling C, Beckford C, Manohar P, Duran S and Cameron AP: Non-surgical urologic management of neurogenic bladder after spinal cord injury. World J Urol. 36:1555–1568. 2018.PubMed/NCBI View Article : Google Scholar

9 

Li YL, Wen JJ, Wen YB, He XF, Wu JW, Li YW, Han ZJ, Feng JJ, Yan SH, Li SL, et al: Reconstruction of bladder function and prevention of renal deterioration by means of end-to-side neurorrhaphy in rats with neurogenic bladder. Neurourol Urodyn. 37:1272–1280. 2018.PubMed/NCBI View Article : Google Scholar

10 

Wada N, Shimizu T, Takai S, Shimizu N, Tyagi P, Kakizaki H and Yoshimura N: Combinational effects of muscarinic receptor inhibition and β3-adrenoceptor stimulation on neurogenic bladder dysfunction in rats with spinal cord injury. Neurourol Urodyn. 36:1039–1045. 2017.PubMed/NCBI View Article : Google Scholar

11 

Duan LJ, Qi J, Kong XJ, Huang T, Qian XQ, Xu D, Liang JH and Kang J: MiR-133 modulates TGF-β1-induced bladder smooth muscle cell hypertrophic and fibrotic response: Implication for a role of microRNA in bladder wall remodeling caused by bladder outlet obstruction. Cell Signal. 27:215–227. 2015.PubMed/NCBI View Article : Google Scholar

12 

Koeck I, Burkhard FC and Monastyrskaya K: Activation of common signaling pathways during remodeling of the heart and the bladder. Biochem Pharmacol. 102:7–19. 2016.PubMed/NCBI View Article : Google Scholar

13 

Sang R, Liu Y, Kong L, Qian L and Liu C: Effect of acellular amnion with increased TGF-β and bFGF levels on the biological behavior of tenocytes. Front Bioeng Biotechnol. 8(446)2020.PubMed/NCBI View Article : Google Scholar

14 

Ikeda Y, Zabbarova IV, Birder LA, Wipf P, Getchell SE, Tyagi P, Fry CH, Drake MJ and Kanai AJ: Relaxin-2 therapy reverses radiation-induced fibrosis and restores bladder function in mice. Neurourol Urodyn. 37:2441–2451. 2018.PubMed/NCBI View Article : Google Scholar

15 

Cho KJ and Kim JC: Management of urinary incontinence with underactive bladder: A review. Int Neurourol J. 24:111–117. 2020.PubMed/NCBI View Article : Google Scholar

16 

Levanovich PE, Diokno A, Hasenau DL, Lajiness M, Pruchnic R and Chancellor MB: Intradetrusor injection of adult muscle-derived cells for the treatment of underactive bladder: Pilot study. Int Urol Nephrol. 47:465–467. 2015.PubMed/NCBI View Article : Google Scholar

17 

Drugs for hypertension. Med Lett Drugs Ther. 62:73–80. 2020.PubMed/NCBI

18 

Liu X, Shan X, Chen H, Li Z, Zhao P, Zhang C, Guo W, Xu M and Lu R: Stachydrine ameliorates cardiac fibrosis through inhibition of angiotensin II/transformation growth factor β1 fibrogenic axis. Front Pharmacol. 10(538)2019.PubMed/NCBI View Article : Google Scholar

19 

Chen Y, Ma Y, He Y, Xing D, Liu E, Yang X, Zhu W, Wang Q and Wen JG: The TGF-β1 pathway is early involved in neurogenic bladder fibrosis of juvenile rats. Pediatr Res. 90:759–767. 2021.PubMed/NCBI View Article : Google Scholar

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

21 

Torimoto K, Matsumoto Y, Gotoh D, Morizawa Y, Miyake M, Samma S, Tanaka N, Hirayama A and Fujimoto K: Overactive bladder induces transient hypertension. BMC Res Notes. 11(196)2018.PubMed/NCBI View Article : Google Scholar

22 

Abolhasanpour N, Eidi A, Hajebrahimi S, Reyhani-Rad S and Hashim H: Effect of cerebrolysin on bladder function after spinal cord injury in female Wistar rats. Int J Urol. 26:917–923. 2019.PubMed/NCBI View Article : Google Scholar

23 

Salehi-Pourmehr H, Rahbarghazi R, Mahmoudi J, Roshangar L, Chapple CR, Hajebrahimi S, Abolhasanpour N and Azghani MR: Intra-bladder wall transplantation of bone marrow mesenchymal stem cells improved urinary bladder dysfunction following spinal cord injury. Life Sci. 221:20–28. 2019.PubMed/NCBI View Article : Google Scholar

24 

Lin CY, Sparks A and Lee YS: Improvement of lower urinary tract function by a selective serotonin 5-HT1A receptor agonist, NLX-112, after chronic spinal cord injury. Exp Neurol. 332(113395)2020.PubMed/NCBI View Article : Google Scholar

25 

Maciejewski CC, Tredget EE and Metcalfe PD: Urodynamic improvements following oral medical therapy for partial bladder outlet obstruction in an animal model. Neurourol Urodyn. 34:286–291. 2015.PubMed/NCBI View Article : Google Scholar

26 

He YL, Wen JG, Pu QS, Wen YB, Zhai RQ, Chen Y, Ma Y, Liu EP, Xing D, Ji FP, et al: Losartan prevents bladder fibrosis and protects renal function in rat with neurogenic paralysis bladder. Neurourol Urodyn. 40:137–146. 2021.PubMed/NCBI View Article : Google Scholar

27 

Hui J, Sharma S, Rajani S and Singh A: The specific molecular composition and structural arrangement of eleutherodactylus coqui gular skin tissue provide its high mechanical compliance. Int J Mol Sci. 21(5593)2020.PubMed/NCBI View Article : Google Scholar

28 

Chen R, Feng Y, Wu J, Song Y, Li H, Shen Q, Li D, Zhang J, Lu Z, Xiao H and Zhang Y: Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor-4-α. Br J Pharmacol. 175:1217–1229. 2018.PubMed/NCBI View Article : Google Scholar

29 

Wipff PJ, Rifkin DB, Meister JJ and Hinz B: Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix. J Cell Biol. 179:1311–1323. 2007.PubMed/NCBI View Article : Google Scholar

30 

Campbell SE and Katwa LC: Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol. 29:1947–1958. 1997.PubMed/NCBI View Article : Google Scholar

31 

Thenappan T, Ormiston ML, Ryan JJ and Archer SL: Pulmonary arterial hypertension: Pathogenesis and clinical management. BMJ. 360(j5492)2018.PubMed/NCBI View Article : Google Scholar

32 

Frismantiene A, Philippova M, Erne P and Resink TJ: Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity. Cell Signal. 52:48–64. 2018.PubMed/NCBI View Article : Google Scholar

33 

Zhang JG, Xing ZY, Zha TT, Tian XJ, Du YN, Chen J and Xing W: Longitudinal assessment of rabbit renal fibrosis induced by unilateral ureteral obstruction using two-dimensional susceptibility weighted imaging. J Magn Reson Imaging. 47:1572–1577. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Wang R, Ma N, Wang C and Chen W: Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats. Exp Ther Med 23: 216, 2022.
APA
Liu, Q., Wang, R., Ma, N., Wang, C., & Chen, W. (2022). Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats. Experimental and Therapeutic Medicine, 23, 216. https://doi.org/10.3892/etm.2022.11140
MLA
Liu, Q., Wang, R., Ma, N., Wang, C., Chen, W."Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats". Experimental and Therapeutic Medicine 23.3 (2022): 216.
Chicago
Liu, Q., Wang, R., Ma, N., Wang, C., Chen, W."Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats". Experimental and Therapeutic Medicine 23, no. 3 (2022): 216. https://doi.org/10.3892/etm.2022.11140
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Wang R, Ma N, Wang C and Chen W: Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats. Exp Ther Med 23: 216, 2022.
APA
Liu, Q., Wang, R., Ma, N., Wang, C., & Chen, W. (2022). Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats. Experimental and Therapeutic Medicine, 23, 216. https://doi.org/10.3892/etm.2022.11140
MLA
Liu, Q., Wang, R., Ma, N., Wang, C., Chen, W."Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats". Experimental and Therapeutic Medicine 23.3 (2022): 216.
Chicago
Liu, Q., Wang, R., Ma, N., Wang, C., Chen, W."Telmisartan inhibits bladder smooth muscle fibrosis in neurogenic bladder rats". Experimental and Therapeutic Medicine 23, no. 3 (2022): 216. https://doi.org/10.3892/etm.2022.11140
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team