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Article

Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis

  • Authors:
    • Bo Wu
    • Gaojing Dou
    • Yuan Zhang
    • Jing Wang
    • Xinhui Wang
    • Shanshan Jiang
    • Sheng Zhong
    • Junan Ren
    • Zhiyun Zhang
    • Jiahui Li
    • Chunjia Sheng
    • Gang Zhao
    • Liyan Zhao
  • View Affiliations / Copyright

    Affiliations: Clinical College, Jilin University, Changchun, Jilin 130021, P.R. China, Institute of Zoology, China Academy of Science, Beijing 100049, P.R. China, Department of Neurosurgery, Cancer Hospital of Sun Yat Sen University, Guangzhou, Guangdong 510060, P.R. China, Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Neurosurgery, The First Bethune Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China
  • Article Number: 217
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    Published online on: January 13, 2022
       https://doi.org/10.3892/etm.2022.11141
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Abstract

The aim of the present study is to identify novel promising marks and targets of diagnosis, therapy and prognosis for patients with vestibular schwannoma at the molecular level. The gene expression profiles of GSE54934, GSE39645 and GSE56597 datasets were obtained respectively from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) were identified by comparing between gene expression profiles of the vestibular schwannoma tissues and normal tissues. Subsequently, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and protein‑protein interaction (PPI) network analysis were performed. The function and pathway enrichment analysis were performed for DEGs with DAVID. Reverse transcription‑quantitative PCR were conducted to confirm the expression of BCL2, AGT, IL6 and ITGA2 in human Schwann cells and vestibular schwannoma cells. A total of 4,025, 1,1291 and 1,513 DEGs were identified from GSE54934, GSE56597 and GSE39645 datasets, respectively. GO and KEGG analysis showed that the mutual upregulated genes were mainly enriched in cell division, mitotic nuclear division, and transition of mitotic cell cycle, whilst mutual downregulated genes were enriched in chemical synaptic transmission, neurotransmitter transport, and synaptic vesicle membrane. Subsequently, 20 genes, including BCL2, AGT, IL6 and ITGA2 were selected as hub genes with high degrees after PPI network analysis. The significant differential expression of those genes were detected among vestibular schwannoma tissues compared with normal nerve tissues. In conclusion, BCL2, AGT, IL6 and ITGA2 are significantly higher expressed in vestibular schwannoma tissues compared with human Schwann tissues. The DEGs identified in the present study provide novel targets for the diagnosis and treatment of vestibular schwannoma.
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1 

Ramaswamy AT and Golub JS: Management of vestibular schwannomas for the radiologist. Neuroimaging Clin N Am. 29:173–182. 2019.PubMed/NCBI View Article : Google Scholar

2 

Mahaley MS Jr, Mettlin C, Natarajan N, Laws ER Jr and Peace BB: Analysis of patterns of care of brain tumor patients in the United States: A study of the brain tumor section of the AANS and the CNS and the commission on cancer of the ACS. Clin Neurosurg. 36:347–352. 1990.PubMed/NCBI

3 

Basu S, Youngs R and Mitchell-Innes A: Screening for vestibular schwannoma in the context of an ageing population. J Laryngol Otol. 133:640–649. 2019.PubMed/NCBI View Article : Google Scholar

4 

Kaul V and Cosetti MK: Management of vestibular schwannoma (Including NF2): Facial nerve considerations. Otolaryng Clin North Am. 51:1193–1212. 2018.PubMed/NCBI View Article : Google Scholar

5 

Martini A, Marioni G, Zanoletti E, Cappellesso R, Stramare R, Fasanaro E, Faccioli C, Giacomelli L, Denaro L, D'Avella D, et al: YAP, TAZ and AREG expression in eighth cranial nerve schwannoma. Int J Biol Markers. 32:e319–e324. 2017.PubMed/NCBI View Article : Google Scholar

6 

Zhang Z, Wang Z, Sun L, Li X, Huang Q, Yang T and Wu H: Mutation spectrum and differential gene expression in cystic and solid vestibular schwannoma. Genet Med. 16:264–270. 2014.PubMed/NCBI View Article : Google Scholar

7 

Torres-Martin M, Lassaletta L, Isla A, De Campos JM, Pinto GR, Burbano RR, Castresana JS, Melendez B and Rey JA: Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue. Oncol Rep. 32:2327–2334. 2014.PubMed/NCBI View Article : Google Scholar

8 

Torres-Martin M, Lassaletta L, San-Roman-Montero J, De Campos JM, Isla A, Gavilan J, Melendez B, Pinto GR, Burbano RR, Castresana JS and Rey JA: Microarray analysis of gene expression in vestibular schwannomas reveals SPP1/MET signaling pathway and androgen receptor deregulation. Int J Oncol. 42:848–862. 2013.PubMed/NCBI View Article : Google Scholar

9 

Torres-Martín M, Lassaletta L, de Campos JM, Isla A, Pinto GR, Burbano RR, Melendez B, Castresana JS and Rey JA: Genome-wide methylation analysis in vestibular schwannomas shows putative mechanisms of gene expression modulation and global hypomethylation at the HOX gene cluster. Genes Chromosomes Cancer. 54:197–209. 2015.PubMed/NCBI View Article : Google Scholar

10 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003.PubMed/NCBI View Article : Google Scholar

11 

Otasek D, Morris JH, Bouças J, Pico AR and Demchak B: Cytoscape automation: Empowering workflow-based network analysis. Genome Biol. 20(185)2019.PubMed/NCBI View Article : Google Scholar

12 

Leng J, Song Q, Zhao Y and Wang Z: miR-15a represses cancer cell migration and invasion under conditions of hypoxia by targeting and downregulating Bcl2 expression in human osteosarcoma cells. Int J Oncol. 52:1095–1104. 2018.PubMed/NCBI View Article : Google Scholar

13 

Mehrian-Shai R, Freedman S, Shams S, Doherty J, Slattery W, Hsu NY, Reichardt JK, Andalibi A and Toren A: Schwannomas exhibit distinct size-dependent gene-expression patterns. Future Oncol. 11:1751–1758. 2015.PubMed/NCBI View Article : Google Scholar

14 

Schulz A, Büttner R, Hagel C, Baader SL, Kluwe L, Salamon J, Mautner VF, Mindos T, Parkinson DB, Gehlhausen JR, et al: The importance of nerve microenvironment for schwannoma development. Acta Neuropathol. 132:289–307. 2016.PubMed/NCBI View Article : Google Scholar

15 

Roche PH, Figarella-Branger D, Daniel L, Bianco N, Pellet W and Pellissier JF: Expression of cell adhesion molecules in normal nerves, chronic axonal neuropathies and Schwann cell tumors. J Neurol Sci. 151:127–133. 1997.PubMed/NCBI View Article : Google Scholar

16 

Padmanaban V, Krol I, Suhail Y, Szczerba BM, Aceto N, Bader JS and Ewald AJ: E-cadherin is required for metastasis in multiple models of breast cancer. Nature. 573:439–444. 2019.PubMed/NCBI View Article : Google Scholar

17 

Wen ZF, Liu H, Gao R, Zhou M, Ma J, Zhang Y, Zhao J, Chen Y, Zhang T, Huang F, et al: Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1. J Immunother Cancer. 6(151)2018.PubMed/NCBI View Article : Google Scholar

18 

Wang S, Liechty B, Patel S, Weber JS, Hollmann TJ, Snuderl M and Karajannis MA: Programmed death ligand 1 expression and tumor infiltrating lymphocytes in neurofibromatosi type 1 and 2 associated tumors. J Neurooncol. 138:183–190. 2018.PubMed/NCBI View Article : Google Scholar

19 

Liang B, Li C and Zhao J: Identification of key pathways and genes in colorectal cancer using bioinformatics analysis. Med Oncol. 33(111)2016.PubMed/NCBI View Article : Google Scholar

20 

Ni X, Ou C, Guo J, Liu B, Zhang J, Wu Z, Li H and Chen M: Lentiviral vector-mediated co-overexpression of VEGF and Bcl-2 improves mesenchymal stem cell survival and enhances paracrine effects in vitro. Int J Mol Med. 40:418–426. 2017.PubMed/NCBI View Article : Google Scholar

21 

Edison N, Curtz Y, Paland N, Mamriev D, Chorubczyk N, Haviv-Reingewertz T, Kfir N, Morgenstern D, Kupervaser M, Kagan J, et al: Degradation of Bcl-2 by XIAP and ARTS promotes apoptosis. Cell Rep. 21:442–454. 2017.PubMed/NCBI View Article : Google Scholar

22 

Ozretic P, Alvir I, Sarcevic B, Vujaskovic Z, Rendic-Miocevic Z, Roguljic A and Beketic-Oreskovic L: Apoptosis regulator Bcl-2 is an independent prognostic marker for worse overall survival in triple-negative breast cancer patients. Int J Biol Markers. 33:109–115. 2018.PubMed/NCBI View Article : Google Scholar

23 

Yan F, Wang C, Li T, Cai W and Sun J: Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma. Mol Med Rep. 17:4237–4244. 2018.PubMed/NCBI View Article : Google Scholar

24 

Butler MJ and Aguiar RCT: Biology informs treatment choices in diffuse large B cell lymphoma. Trends Cancer. 3:871–882. 2017.PubMed/NCBI View Article : Google Scholar

25 

Feng L, Zhu J, Sun W, Zhao J and Liu Y: Expressions of gastrin and apoptosis-associated proteins involved in mitochondrial pathway in gastric cancer tissues and the clinical significance. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 33:1557–1561. 2017.PubMed/NCBI(In Chinese).

26 

You ML, Chen YJ, Chong QY, Wu MM, Pandey V, Chen RM, Liu L, Ma L, Wu ZS, Zhu T and Lobie PE: Trefoil factor 3 mediation of oncogenicity and chemoresistance in hepatocellular carcinoma is AKT-BCL-2 dependent. Oncotarget. 8:39323–39344. 2017.PubMed/NCBI View Article : Google Scholar

27 

Liu F, Tong D, Li H, Liu M, Li J, Wang Z and Cheng X: Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway. Oncotarget. 7:8896–8907. 2016.PubMed/NCBI View Article : Google Scholar

28 

Sato Y, Kubo T, Morimoto K, Yanagihara K and Seyama T: High mannose-binding Pseudomonas fluorescens lectin (PFL) downregulates cell surface integrin/EGFR and induces autophagy in gastric cancer cells. BMC Cancer. 16(63)2016.PubMed/NCBI View Article : Google Scholar

29 

Wu SJ, Soulez M, Yang YH, Chu CS, Shih SC, Hebert MJ, Kuo MC and Hsieh YJ: Local augmented angiotensinogen secreted from apoptotic vascular endothelial cells is a vital mediator of vascular remodelling. PLoS One. 10(e0132583)2015.PubMed/NCBI View Article : Google Scholar

30 

Meinert C, Gembardt F, Bohme I, Tetzner A, Wieland T, Greenberg B and Walther T: Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7). J Proteomics. 130:129–139. 2016.PubMed/NCBI View Article : Google Scholar

31 

Citron M, Decker R, Chen S, Schneider S, Graver M, Kleynerman L, Kahn LB, White A, Schoenhaus M and Yarosh D: O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary. Cancer Res. 51:4131–4134. 1991.PubMed/NCBI

32 

Deckers IA, van den Brandt PA, van Engeland M, van Schooten FJ, Godschalk RW, Keszei AP and Schouten LJ: Polymorphisms in genes of the renin-angiotensin-aldosterone system and renal cell cancer risk: Interplay with hypertension and intakes of sodium, potassium and fluid. Int J Cancer. 136:1104–1116. 2015.PubMed/NCBI View Article : Google Scholar

33 

Martin P, Noonan S, Mullen MP, Scaife C, Tosetto M, Nolan B, Wynne K, Hyland J, Sheahan K, Elia G, et al: Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer. BMC Cancer. 14(887)2014.PubMed/NCBI View Article : Google Scholar

34 

Deng G, Kakar S, Okudiara K, Choi E, Sleisenger MH and Kim YS: Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs. Clin Cancer Res. 15:1519–1526. 2009.PubMed/NCBI View Article : Google Scholar

35 

Sameni M, Cavallo-Medved D, Franco OE, Chalasani A, Ji K, Aggarwal N, Anbalagan A, Chen X, Mattingly RR, Hayward SW and Sloane BF: Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ. Breast Cancer Res. 19(56)2017.PubMed/NCBI View Article : Google Scholar

36 

Chen C and Zhang X: IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling. J Transl Med. 15(42)2017.PubMed/NCBI View Article : Google Scholar

37 

Ortiz-Montero P, Londono-Vallejo A and Vernot JP: Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line. Cell Commun Signal. 15(17)2017.PubMed/NCBI View Article : Google Scholar

38 

Zhou J, Zhang C, Pan J, Chen L and Qi ST: Interleukin6 induces an epithelialmesenchymal transition phenotype in human adamantinomatous craniopharyngioma cells and promotes tumor cell migration. Mol Med Rep. 15:4123–4131. 2017.PubMed/NCBI View Article : Google Scholar

39 

Albino D, Civenni G, Rossi S, Mitra A, Catapano CV and Carbone GM: The ETS factor ESE3/EHF represses IL-6 preventing STAT3 activation and expansion of the prostate cancer stem-like compartment. Oncotarget. 7:76756–76768. 2016.PubMed/NCBI View Article : Google Scholar

40 

Thomsen M, Kersten C, Sorbye H, Skovlund E, Glimelius B, Pfeiffer P, Johansen JS, Kure EH, Ikdahl T, Tveit KM, et al: Interleukin-6 and C-reactive protein as prognostic biomarkers in metastatic colorectal cancer. Oncotarget. 7:75013–75022. 2016.PubMed/NCBI View Article : Google Scholar

41 

Adams EF, Rafferty B, Mower J, Ward H, Petersen B and Fahlbusch R: Human acoustic neuromas secrete interleukin-6 in cell culture: Possible autocrine regulation of cell proliferation. Neurosurgery. 35:434–438. 1994.PubMed/NCBI View Article : Google Scholar

42 

Taurone S, Bianchi E, Attanasio G, Di Gioia C, Ierinó R, Carubbi C, Galli D, Pastore FS, Giangaspero F, Filipo R, et al: Immunohistochemical profile of cytokines and growth factors expressed in vestibular schwannoma and in normal vestibular nerve tissue. Mol Med Rep. 12:737–745. 2015.PubMed/NCBI View Article : Google Scholar

43 

Ferraro A, Boni T and Pintzas A: EZH2 regulates cofilin activity and colon cancer cell migration by targeting ITGA2 gene. PLoS One. 9(e115276)2014.PubMed/NCBI View Article : Google Scholar

44 

Yang Q, Bavi P, Wang JY and Roehrl MH: Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases. J Proteomics. 168:53–65. 2017.PubMed/NCBI View Article : Google Scholar

45 

Dong J, Wang R, Ren G, Li X, Wang J, Sun Y, Liang J, Nie Y, Wu K, Feng B, et al: HMGA2-FOXL2 axis regulates metastases and epithelial-to-mesenchymal transition of chemoresistant gastric cancer. Clin Cancer Res. 23:3461–3473. 2017.PubMed/NCBI View Article : Google Scholar

46 

Ban EZ, Lye MS, Chong PP, Yap YY, Lim SYC and Abdul Rahman H: Haplotype CGC from XPD, hOGG1 and ITGA2 polymorphisms increases the risk of nasopharyngeal carcinoma in Malaysia. PLoS One. 12(e0187200)2017.PubMed/NCBI View Article : Google Scholar

47 

Liu X, Liang Z, Gao K, Li H, Zhao G, Wang S and Fang J: MicroRNA-128 inhibits EMT of human osteosarcoma cells by directly targeting integrin α2. Tumour Biol. 37:7951–7957. 2016.PubMed/NCBI View Article : Google Scholar

48 

Ding W, Fan XL, Xu X, Huang JZ, Xu SH, Geng Q, Li R, Chen D and Yan GR: Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancer. PLoS One. 10(e0135128)2015.PubMed/NCBI View Article : Google Scholar

49 

Ma HY, Liu XZ and Liang CM: Inflammatory microenvironment contributes to epithelial-mesenchymal transition in gastric cancer. World J Gastroenterol. 22:6619–6628. 2016.PubMed/NCBI View Article : Google Scholar

50 

McNab F, Mayer-Barber K, Sher A, Wack A and O'Garra A: Type I interferons in infectious disease. Nat Rev Immunol. 15:87–103. 2015.PubMed/NCBI View Article : Google Scholar

51 

Wang Y, Li P, Wang B, Wang S and Liu P: Identification of myeloid-derived suppressor cells that have an immunosuppressive function in NF2 patients. J Cancer Res Clin Oncol. 145:523–533. 2019.PubMed/NCBI View Article : Google Scholar

52 

Bonetti B, Valdo P, Ossi G, De Toni L, Masotto B, Marconi S, Rizzuto N, Nardelli E and Moretto G: T-cell cytotoxicity of human Schwann cells: TNFalpha promotes fasL-mediated apoptosis and IFN gamma perforin-mediated lysis. Glia. 43:141–148. 2003.PubMed/NCBI View Article : Google Scholar

53 

Cao L, Yang G, Gao S, Jing C, Montgomery RR, Yin Y, Wang P, Fikrig E and You F: HIPK2 is necessary for type I interferon-mediated antiviral immunity. Sci Signal. 12(eaau4604)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wu B, Dou G, Zhang Y, Wang J, Wang X, Jiang S, Zhong S, Ren J, Zhang Z, Li J, Li J, et al: Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis. Exp Ther Med 23: 217, 2022.
APA
Wu, B., Dou, G., Zhang, Y., Wang, J., Wang, X., Jiang, S. ... Zhao, L. (2022). Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis. Experimental and Therapeutic Medicine, 23, 217. https://doi.org/10.3892/etm.2022.11141
MLA
Wu, B., Dou, G., Zhang, Y., Wang, J., Wang, X., Jiang, S., Zhong, S., Ren, J., Zhang, Z., Li, J., Sheng, C., Zhao, G., Zhao, L."Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis". Experimental and Therapeutic Medicine 23.3 (2022): 217.
Chicago
Wu, B., Dou, G., Zhang, Y., Wang, J., Wang, X., Jiang, S., Zhong, S., Ren, J., Zhang, Z., Li, J., Sheng, C., Zhao, G., Zhao, L."Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis". Experimental and Therapeutic Medicine 23, no. 3 (2022): 217. https://doi.org/10.3892/etm.2022.11141
Copy and paste a formatted citation
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Spandidos Publications style
Wu B, Dou G, Zhang Y, Wang J, Wang X, Jiang S, Zhong S, Ren J, Zhang Z, Li J, Li J, et al: Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis. Exp Ther Med 23: 217, 2022.
APA
Wu, B., Dou, G., Zhang, Y., Wang, J., Wang, X., Jiang, S. ... Zhao, L. (2022). Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis. Experimental and Therapeutic Medicine, 23, 217. https://doi.org/10.3892/etm.2022.11141
MLA
Wu, B., Dou, G., Zhang, Y., Wang, J., Wang, X., Jiang, S., Zhong, S., Ren, J., Zhang, Z., Li, J., Sheng, C., Zhao, G., Zhao, L."Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis". Experimental and Therapeutic Medicine 23.3 (2022): 217.
Chicago
Wu, B., Dou, G., Zhang, Y., Wang, J., Wang, X., Jiang, S., Zhong, S., Ren, J., Zhang, Z., Li, J., Sheng, C., Zhao, G., Zhao, L."Identification of key pathways and genes in vestibular schwannoma using bioinformatics analysis". Experimental and Therapeutic Medicine 23, no. 3 (2022): 217. https://doi.org/10.3892/etm.2022.11141
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