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Review Open Access

Benefits and adverse events of melatonin use in the elderly (Review)

  • Authors:
    • Lucreția Anghel
    • Liliana Baroiu
    • Corina Rișcă Popazu
    • Diana Pătraș
    • Silvia Fotea
    • Alexandru Nechifor
    • Anamaria Ciubara
    • Luiza Nechita
    • Carmina Liana Mușat
    • Ioana Anca Stefanopol
    • Alin Laurențiu Tatu
    • Alexandru Bogdan Ciubara
  • View Affiliations / Copyright

    Affiliations: Clinical Medical Department, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800008 Galați, Romania, Internal Medicine Department, St. Andrew The Apostle Clinical Emergency County Hospital, 800578 Galați, Romania, Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunărea de Jos’ University, 800008 Galați, Romania
    Copyright: © Anghel et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 219
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    Published online on: January 14, 2022
       https://doi.org/10.3892/etm.2022.11142
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Abstract

Melatonin is a hormone secreted by the pineal gland in accordance with the circadian rhythm when the light level decreases. Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting the suprachiasmatic nucleus or of the neuronal pathways of transmission to the pineal gland. A significant decrease in melatonin synthesis has been reported in various disorders and diseases, including cardiovascular diseases, metabolic disorders (particularly diabetes type 2), cancer and endocrine diseases. In addition to the fact, that melatonin is a sleep inducer, it also exerts cytoprotective properties as an antioxidant and free radical scavenger. The therapeutic role of melatonin has been demonstrated in sleep disorders, eye damage and cardiovascular disease. The association between melatonin and β‑blockers has had a positive impact on sleep disorders in clinical trials. Previous studies have reported the anti‑inflammatory effect of melatonin by adjusting levels of pro‑inflammatory cytokines, including interleukin (IL)‑6, IL‑1β and tumor necrosis factor‑α. Melatonin treatment has been demonstrated to decrease IL‑6 and IL‑10 expression levels and efficiently attenuate T‑cell proliferation. Currently, there is an inconsistency of scientific data regarding the lowest optimal dose and safety of melatonin for long‑term use. The aim of the present review was to summarize the evidence on the role of melatonin in various clinical conditions and highlight the future research in this area.
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Copy and paste a formatted citation
Spandidos Publications style
Anghel L, Baroiu L, Popazu CR, Pătraș D, Fotea S, Nechifor A, Ciubara A, Nechita L, Mușat CL, Stefanopol IA, Stefanopol IA, et al: Benefits and adverse events of melatonin use in the elderly (Review). Exp Ther Med 23: 219, 2022.
APA
Anghel, L., Baroiu, L., Popazu, C.R., Pătraș, D., Fotea, S., Nechifor, A. ... Ciubara, A.B. (2022). Benefits and adverse events of melatonin use in the elderly (Review). Experimental and Therapeutic Medicine, 23, 219. https://doi.org/10.3892/etm.2022.11142
MLA
Anghel, L., Baroiu, L., Popazu, C. R., Pătraș, D., Fotea, S., Nechifor, A., Ciubara, A., Nechita, L., Mușat, C. L., Stefanopol, I. A., Tatu, A. L., Ciubara, A. B."Benefits and adverse events of melatonin use in the elderly (Review)". Experimental and Therapeutic Medicine 23.3 (2022): 219.
Chicago
Anghel, L., Baroiu, L., Popazu, C. R., Pătraș, D., Fotea, S., Nechifor, A., Ciubara, A., Nechita, L., Mușat, C. L., Stefanopol, I. A., Tatu, A. L., Ciubara, A. B."Benefits and adverse events of melatonin use in the elderly (Review)". Experimental and Therapeutic Medicine 23, no. 3 (2022): 219. https://doi.org/10.3892/etm.2022.11142
Copy and paste a formatted citation
x
Spandidos Publications style
Anghel L, Baroiu L, Popazu CR, Pătraș D, Fotea S, Nechifor A, Ciubara A, Nechita L, Mușat CL, Stefanopol IA, Stefanopol IA, et al: Benefits and adverse events of melatonin use in the elderly (Review). Exp Ther Med 23: 219, 2022.
APA
Anghel, L., Baroiu, L., Popazu, C.R., Pătraș, D., Fotea, S., Nechifor, A. ... Ciubara, A.B. (2022). Benefits and adverse events of melatonin use in the elderly (Review). Experimental and Therapeutic Medicine, 23, 219. https://doi.org/10.3892/etm.2022.11142
MLA
Anghel, L., Baroiu, L., Popazu, C. R., Pătraș, D., Fotea, S., Nechifor, A., Ciubara, A., Nechita, L., Mușat, C. L., Stefanopol, I. A., Tatu, A. L., Ciubara, A. B."Benefits and adverse events of melatonin use in the elderly (Review)". Experimental and Therapeutic Medicine 23.3 (2022): 219.
Chicago
Anghel, L., Baroiu, L., Popazu, C. R., Pătraș, D., Fotea, S., Nechifor, A., Ciubara, A., Nechita, L., Mușat, C. L., Stefanopol, I. A., Tatu, A. L., Ciubara, A. B."Benefits and adverse events of melatonin use in the elderly (Review)". Experimental and Therapeutic Medicine 23, no. 3 (2022): 219. https://doi.org/10.3892/etm.2022.11142
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