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Article

Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance

  • Authors:
    • Chaosheng Li
    • Lingling Hu
    • Jilai Zhao
    • Meiqi Di
    • Changyan Fan
    • Likun Han
    • Xuying Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Wuxi Third People's Hospital, Wuxi, Jiangsu 214000, P.R. China, Department of Neurology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China
  • Article Number: 223
    |
    Published online on: January 17, 2022
       https://doi.org/10.3892/etm.2022.11147
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Abstract

The present study aimed to explore the effects and clinical importance of serum interleukin (IL) IL‑1β, IL‑6, C‑reactive protein (CRP), intercellular adhesion molecule (ICAM)‑1 and matrix metalloproteinase (MMP)‑2 in patients with acute cerebral infarction undergoing intravenous thrombolysis during simultaneous hypothermia therapy. A total of 80 patients with acute cerebral infarction who were treated at our hospital were randomly selected. They were divided into groups A and B. The two groups were treated with intravenous thrombolysis, while group B received sub‑hypothermia treatment. Prior to treatment and at 7 days after treatment, 5 ml of venous blood was collected and stored in a freezer at ‑80˚C. IL‑1β, IL‑6, CRP, ICAM‑1 and MMP‑2 levels were detected by ELISA and compared between the groups and time‑points. The results were as follows: i) At 7 days after treatment, the levels of IL‑1β, IL‑6, CRP, ICAM‑1 and MMP‑2 in group B were significantly decreased compared with those in group A (P<0.05), while there was no significant difference of these levels between group A and B before treatment (P>0.05). The incidence of adverse reactions in group A and group B was 35 and 20% respectively, and the mortality rate was 10 and 5%, respectively. There were no significant differences in adverse events and mortality between the two groups (P>0.05). In addition, a positive correlation of the level of IL‑1β, IL‑6, CRP, ICAM‑1 and MMP‑2 with the National Institutes of Health Stroke Scale score was determined in the patients prior to treatment. In conclusion, mild hypothermia treatment in addition to intravenous thrombolysis significantly reduced the levels of IL‑1β, IL‑6, CRP, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and reduced inflammation, and should therefore be incorporated in clinical practice.
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Copy and paste a formatted citation
Spandidos Publications style
Li C, Hu L, Zhao J, Di M, Fan C, Han L and Zhu X: Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance. Exp Ther Med 23: 223, 2022.
APA
Li, C., Hu, L., Zhao, J., Di, M., Fan, C., Han, L., & Zhu, X. (2022). Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance. Experimental and Therapeutic Medicine, 23, 223. https://doi.org/10.3892/etm.2022.11147
MLA
Li, C., Hu, L., Zhao, J., Di, M., Fan, C., Han, L., Zhu, X."Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance". Experimental and Therapeutic Medicine 23.3 (2022): 223.
Chicago
Li, C., Hu, L., Zhao, J., Di, M., Fan, C., Han, L., Zhu, X."Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance". Experimental and Therapeutic Medicine 23, no. 3 (2022): 223. https://doi.org/10.3892/etm.2022.11147
Copy and paste a formatted citation
x
Spandidos Publications style
Li C, Hu L, Zhao J, Di M, Fan C, Han L and Zhu X: Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance. Exp Ther Med 23: 223, 2022.
APA
Li, C., Hu, L., Zhao, J., Di, M., Fan, C., Han, L., & Zhu, X. (2022). Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance. Experimental and Therapeutic Medicine, 23, 223. https://doi.org/10.3892/etm.2022.11147
MLA
Li, C., Hu, L., Zhao, J., Di, M., Fan, C., Han, L., Zhu, X."Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance". Experimental and Therapeutic Medicine 23.3 (2022): 223.
Chicago
Li, C., Hu, L., Zhao, J., Di, M., Fan, C., Han, L., Zhu, X."Effect of intravenous thrombolysis combined with mild hypothermia on the levels of IL‑1β, IL‑6, ICAM‑1 and MMP‑2 in patients with acute cerebral infarction and clinical significance". Experimental and Therapeutic Medicine 23, no. 3 (2022): 223. https://doi.org/10.3892/etm.2022.11147
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