Open Access

Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non‑smokers

  • Authors:
    • Razvan Mercut
    • Irina Maria Mercut
    • Adina Dorina Glodeanu
    • Mihaela Ionescu
    • Adina Turcu
    • Alin Stefanescu‑Dima
    • Marius Eugen Ciurea
  • View Affiliations

  • Published online on: January 21, 2022     https://doi.org/10.3892/etm.2022.11159
  • Article Number: 234
  • Copyright: © Mercut et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

During the past few years, several studies have demonstrated that head and neck carcinomas present more aggressive forms for smokers, relative to non‑smokers. Our aim was to investigate the tumor aggressiveness for patients with eyelid carcinomas, in relation to tobacco consumption, as well as other demographic and clinical data. For 98 patients with eyelid carcinomas, we studied the relationship between the duration of their symptoms and their tumor stage at first diagnosis, trying to determine potential correlations with smoking status and several other clinical parameters. Our data revealed that, for the same duration of symptoms, tobacco consumers tended to have higher tumor stages, which did not correlate with other variables. For early diagnosed tumors, within the first year of symptoms, smokers presented 6.044 times higher odds to exhibit more advanced tumor stages, compared to non‑smokers, and this value decreased to 4.501, up to 5 years of the presence of symptoms (P<0.05). We also noted that, for smokers, an increased age was associated with increased tumor stages, which was opposed to non‑smokers, regardless of their symptom duration [average odds ratio (OR) 1.122, P<0.05]. Tumor aggressiveness was therefore associated with tobacco consumption, leading to an increased risk of developing more aggressive forms of eyelid carcinomas for smokers, compared to non‑smokers.
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March-2022
Volume 23 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Mercut R, Mercut IM, Glodeanu AD, Ionescu M, Turcu A, Stefanescu‑Dima A and Ciurea ME: Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non‑smokers. Exp Ther Med 23: 234, 2022
APA
Mercut, R., Mercut, I.M., Glodeanu, A.D., Ionescu, M., Turcu, A., Stefanescu‑Dima, A., & Ciurea, M.E. (2022). Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non‑smokers. Experimental and Therapeutic Medicine, 23, 234. https://doi.org/10.3892/etm.2022.11159
MLA
Mercut, R., Mercut, I. M., Glodeanu, A. D., Ionescu, M., Turcu, A., Stefanescu‑Dima, A., Ciurea, M. E."Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non‑smokers". Experimental and Therapeutic Medicine 23.3 (2022): 234.
Chicago
Mercut, R., Mercut, I. M., Glodeanu, A. D., Ionescu, M., Turcu, A., Stefanescu‑Dima, A., Ciurea, M. E."Eyelid carcinomas: Tumor aggressiveness tendencies for smokers compared to non‑smokers". Experimental and Therapeutic Medicine 23, no. 3 (2022): 234. https://doi.org/10.3892/etm.2022.11159