Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
March-2022 Volume 23 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2022 Volume 23 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors

  • Authors:
    • Tao Feng
    • Qinqin Zhang
    • Jiasha Wei
    • Xiao Wang
    • Yang Geng
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China
    Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 242
    |
    Published online on: January 27, 2022
       https://doi.org/10.3892/etm.2022.11167
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The causes of sudden sensorineural hearing loss (SSNHL) are unclear, and the condition cannot be treated with specific regimens. The present study was designed to explore the effects of alprostadil combined with hyperbaric oxygen (HBO) on hearing recovery and hemorheology in patients with SSNHL, and to analyze factors influencing treatment efficacy. in total, 104 patients with SSNHL were enrolled between January 2015 and July 2018 in a randomized controlled trial. Group A (n=52) received alprostadil treatment and Group B (n=52) were treated with HBO plus alprostadil. Following treatment, the overall recovery rates of tinnitus, aural fullness and vertigo in Group B were significantly higher than those in Group A (P<0.05). Low‑, middle‑ and high‑shear whole blood viscosity and whole blood viscosity in the two groups significantly decreased, and those in Group B were significantly lower than those in Group A (P<0.05). The present results indicated that the combination of alprostadil with HBO can improve the therapeutic effect on SSNHL, reduce blood viscosity and improve coagulation function, thus significantly promoting hearing recovery. Further, SSNHL treatment efficacy was influenced by age, time of onset, hearing threshold, presence or absence of tinnitus, plasma viscosity and serum C‑reactive protein levels. The trial registration number for the present study was: NCT02563872.
View Figures

Figure 1

Figure 2

View References

1 

Furuhashi A, Matsuda K, Asahi K and Nakashima T: Sudden deafness: Long-term follow-up and recurrence. Clin Otolaryngol Allied Sci. 27:458–463. 2002.PubMed/NCBI View Article : Google Scholar

2 

Research on deafness. Doctoral dissertations. Am Ann Deaf. 147:230–233. 2002.PubMed/NCBI

3 

Hirayama M, Shitara T, Okamoto M and Sano H: Idiopathic bilateral sensorineural hearing loss: Its clinical study in cases with rapidly progressed deafness. Acta Otolaryngol Suppl. 534:39–42. 1996.PubMed/NCBI View Article : Google Scholar

4 

Qiu L, Zheng X, Xie F, Zhang M, Zhang J, Yuan SB and Zeng GZ: Clinical observation on the different frequency hearing damages in sudden deafness treated by electroacupuncture combined with western medicine comprehensive therapy. World J Acupunct Moxibustion. 22:22–27. 2012.

5 

Inagaki T, Cureoglu S, Morita N, Terao K, Sato T, Suzuki M and Paparella MM: Vestibular system changes in sudden deafness with and without vertigo: A human temporal bone study. Otol Neurotol. 33:1151–1155. 2012.PubMed/NCBI View Article : Google Scholar

6 

Ersoy Callioglu E, Tuzuner A, Demirci S, Cengiz C and Caylan R: Comparison of simultaneous systemic steroid and hyperbaric oxygen treatment versus only steroid in idiopathic sudden sensorineural hearing loss. Int J Clin Exp Med. 8:9876–9682. 2015.PubMed/NCBI

7 

Augustin AJ, Diehm C, Grieger F and Bentz J: Alprostadil infusion in patients with dry age related macular degeneration: A randomized controlled clinical trial. Expert Opin Investig Drugs. 22:803–812. 2013.PubMed/NCBI View Article : Google Scholar

8 

Güneysu E, Koçman AE, Özatik O, Ovali C, Can B, Alataş İÖ and Sevin MB: The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle. Turk J Med Sci. 47:1028–1036. 2017.PubMed/NCBI View Article : Google Scholar

9 

de Pont AC, de Jonge E and Vroom MB: Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med. 348:557–560. 2003.PubMed/NCBI View Article : Google Scholar

10 

Li J, Shi Q, Wei Q and Han P: Re: Efficacy and safety of mirodenafil for patients with erectile dysfunction: A meta-analysis of three multicenter, randomized, double-blind, placebo-controlled clinical trials. Aging Male. 18(71)2015.PubMed/NCBI View Article : Google Scholar

11 

Wei KU, Liu Y, Jing WU, Wang Q, Tong B and Duan M: Meta-analysis of the clinical efficacy of treatment of sudden deafness using hyperbaric oxygen combined with drug in China. Chin J Otol. 12:93–98. 2014.

12 

Arndt S, Laszig R, Aschendorff A, Hassepass F, Beck R and Wesarg T: Cochlear implant treatment of patients with single-sided deafness or asymmetric hearing loss. German version. HNO. 65:586–598. 2017.PubMed/NCBI View Article : Google Scholar : (In German).

13 

Weiss D, Böcker AJ, Koopmann M, Savvas E, Borowski M and Rudack C: Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss. J Otolaryngol Head Neck Surg. 46(27)2017.PubMed/NCBI View Article : Google Scholar

14 

Zhai S, Ning Y, Guiliang Z, Yuhua Z and He Q: Effect of retreatment on the end-stage sudden deafness. Cell Biochem Biophys. 62:403–406. 2012.PubMed/NCBI View Article : Google Scholar

15 

Merchant SN, Durand ML and Adams JC: Sudden deafness: Is it viral? ORL J Otorhinolaryngol Relat Spec. 70:52–62. 2008.PubMed/NCBI View Article : Google Scholar

16 

Ban JH, Hong SJ, Lee SY, Lee KC and Kim CG: A clinical analysis of psychogenic hearing loss presenting as sudden deafness. Korean J Otolaryngol Head Neck Surg. 48:572–576. 2005.PubMed/NCBI View Article : Google Scholar

17 

Domachevsky L, Keynan Y, Shupak A and Adir Y: Hyperbaric oxygen in the treatment of sudden deafness. Eur Arch Otorhinolaryngol. 264:951–953. 2007.PubMed/NCBI View Article : Google Scholar

18 

Kornberg A: Letter: Prostaglandin E1 therapy with alprostadil and risk reduction of early hepatic cellular carcinoma after liver transplantation-authors' reply. Aliment Pharmacol Ther. 43:173–174. 2016.PubMed/NCBI View Article : Google Scholar

19 

Liu Y, Sun D, Shao S, Jiang W, Sun Z and Li Z: The effect of hyperbaric oxygen therapy to different degree of hearing loss and types of threshold curve in sudden deafness patients. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 24:890–894. 2010.PubMed/NCBI(In Chinese).

20 

Tatar S, Orhan N, Yilmaz CU, Arican N, Ahishali B, Kucuk M, Elmas I, Kaya M and Toklu AS: Hyperbaric oxygen therapy for five days increases blood-brain barrier permeability. Undersea Hyperb Med. 44:345–355. 2017.PubMed/NCBI View Article : Google Scholar

21 

Jiang J, Wang S and Tong K: Synergic effect of alprostadil injection and ginaton in treating sudden deafness. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 25:597–599. 2011.PubMed/NCBI(In Chinese).

22 

Xin W, Wen HL, Zhao Q and Zhao ZW: Blood dilution, hyperbaric oxygen, anticoagulation treatment for acute carbon monoxide poisoning 115 patients. Chinese Journal of Medicinal Guide. 45–47. 2008.

23 

Hernández-Tejedor A, Cabré-Pericas L, Martín-Delgado MC, Leal-Micharet AM and Algora-Weber A: EPIPUSE study group. Evolution and prognosis of long intensive care unit stay patients suffering a deterioration: A multicenter study. J Crit Care. 30:654.e1–e7. 2015.PubMed/NCBI View Article : Google Scholar

24 

Ren J and Lu Y: Sudden deafness in the elderly. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 12:257–259. 1998.PubMed/NCBI(In Chinese).

25 

Liberman MC: Noise-induced hearing loss: Permanent versus temporary threshold shifts and the effects of hair cell versus neuronal degeneration. Adv Exp Med Biol. 875:1–7. 2016.PubMed/NCBI View Article : Google Scholar

26 

Gao D, Shao J, Jin W, Xia X and Qu Y: Correlations of serum cystatin C and hs-CRP with vascular endothelial cell injury in patients with systemic lupus erythematosus. Panminerva Med. 60:151–155. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Feng T, Zhang Q, Wei J, Wang X and Geng Y: Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors. Exp Ther Med 23: 242, 2022.
APA
Feng, T., Zhang, Q., Wei, J., Wang, X., & Geng, Y. (2022). Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors. Experimental and Therapeutic Medicine, 23, 242. https://doi.org/10.3892/etm.2022.11167
MLA
Feng, T., Zhang, Q., Wei, J., Wang, X., Geng, Y."Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors". Experimental and Therapeutic Medicine 23.3 (2022): 242.
Chicago
Feng, T., Zhang, Q., Wei, J., Wang, X., Geng, Y."Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors". Experimental and Therapeutic Medicine 23, no. 3 (2022): 242. https://doi.org/10.3892/etm.2022.11167
Copy and paste a formatted citation
x
Spandidos Publications style
Feng T, Zhang Q, Wei J, Wang X and Geng Y: Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors. Exp Ther Med 23: 242, 2022.
APA
Feng, T., Zhang, Q., Wei, J., Wang, X., & Geng, Y. (2022). Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors. Experimental and Therapeutic Medicine, 23, 242. https://doi.org/10.3892/etm.2022.11167
MLA
Feng, T., Zhang, Q., Wei, J., Wang, X., Geng, Y."Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors". Experimental and Therapeutic Medicine 23.3 (2022): 242.
Chicago
Feng, T., Zhang, Q., Wei, J., Wang, X., Geng, Y."Effects of alprostadil combined with hyperbaric oxygen on hearing recovery and hemorheology in patients with sudden sensorineural hearing loss and analysis of related influencing factors". Experimental and Therapeutic Medicine 23, no. 3 (2022): 242. https://doi.org/10.3892/etm.2022.11167
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team