Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2022 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2022 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway

  • Authors:
    • Ling-Ling Xie
    • Shan-Shan Li
    • Yong-Jian Fan
    • Man-Man Qi
    • Zhuang-Zhuang Li
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Clinical Lab, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Ultrasonography, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 248
    |
    Published online on: January 31, 2022
       https://doi.org/10.3892/etm.2022.11173
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Melatonin is a hormone produced by the pineal gland. Given its capabilities of neuroprotection and low neurotoxicity, melatonin could be a therapeutic strategy for traumatic brain injury (TBI). The present study was conducted to determine the neuroprotective effects of melatonin on TBI‑induced anxiety and the possible molecular mechanism. Rats were randomly divided into seven groups. The rodent model of TBI was established using the weight‑drop method. Melatonin was administered by intraperitoneal injection at a dose of 10 mg/kg after TBI. H89 (0.02 mg/kg), a special protein kinase A (PKA) inhibitor, or dibutyryl‑cyclic adenosine monophosphate (cAMP; 0.1 mg/kg), an activator of PKA, were administered by stereotactic injection of the brain to evaluate the roles of PKA and cAMP‑response element‑binding protein (CREB) in melatonin‑related mood regulation, respectively. At 30 days post‑TBI, the changes in anxiety‑like behaviors in rats were measured using the open field and elevated plus maze tests. At 24 h post‑TBI, the number of activated astrocytes and neuronal apoptosis were evaluated using immunofluorescence assay. The expression levels of inflammatory cytokines (TNF‑α and IL‑6) in the amygdala were measured using an enzyme‑linked immunosorbent assay. The expression levels of PKA, phosphorylated (p)‑PKA, CREB, p‑CREB, NF‑κB and p‑NF‑κB in the amygdala were detected using western blotting. It was revealed that melatonin partially reversed TBI‑induced anxiety‑like behavior in rats, and decreased the number of activated astrocytes and neuronal apoptosis in the amygdala induced by TBI. H89 partially blocked the neuroprotective effects of melatonin; while dibutyryl‑cAMP not only reduced the H89‑induced emotional disturbance but also enhanced the protective effects of melatonin against TBI. Overall, melatonin can alleviate TBI‑induced anxiety‑like behaviors in rats. Moreover, the underlying mechanism may be associated with the activation of the PKA/CREB signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Studlack PE, Keledjian K, Farooq T, Akintola T, Gerzanich V, Simard JM and Keller A: Blast-induced brain injury in rats leads to transient vestibulomotor deficits and persistent orofacial pain. Brain Inj. 32:1866–1878. 2018.PubMed/NCBI View Article : Google Scholar

2 

Capizzi A, Woo J and Verduzco-Gutierrez M: Traumatic brain injury: An overview of epidemiology, pathophysiology, and medical management. Med Clin North Am. 104:213–238. 2020.PubMed/NCBI View Article : Google Scholar

3 

Yatsiv I, Grigoriadis N, Simeonidou C, Stahel PF, Schmidt OI, Alexandrovitch AG, Tsenter J and Shohami E: Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury. FASEB J. 19:1701–1703. 2005.PubMed/NCBI View Article : Google Scholar

4 

Adibhatla RM and Hatcher JF: Lipid oxidation and peroxidation in CNS health and disease: From molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 12:125–169. 2010.PubMed/NCBI View Article : Google Scholar

5 

Adhikari A, Lerner TN, Finkelstein J, Pak S, Jennings JH, Davidson TJ, Ferenczi E, Gunaydin LA, Mirzabekov JJ, Ye L, et al: Basomedial amygdala mediates top-down control of anxiety and fear. Nature. 527:179–185. 2015.PubMed/NCBI View Article : Google Scholar

6 

Jayakar R, Tone EB, Crosson B, Turner JA, Anderson PL, Phan KL and Klumpp H: Amygdala volume and social anxiety symptom severity: Does segmentation technique matter? Psychiatry Res Neuroimaging. 295(111006)2020.PubMed/NCBI View Article : Google Scholar

7 

Ji J, Kline AE, Amoscato A, Samhan-Arias AK, Sparvero LJ, Tyurin VA, Tyurina YY, Fink B, Manole MD, Puccio AM, et al: Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Nat Neurosci. 15:1407–1413. 2012.PubMed/NCBI View Article : Google Scholar

8 

Hill RL, Singh IN, Wang JA, Kulbe JR and Hall ED: Protective effects of phenelzine administration on synaptic and non-synaptic cortical mitochondrial function and lipid peroxidation-mediated oxidative damage following TBI in young adult male rats. Exp Neurol. 2020(113322)2020.PubMed/NCBI View Article : Google Scholar

9 

Chiu CC, Liao YE, Yang LY and Wang JY, Tweedie D, Karnati HK, Greig NH and Wang JY: Neuroinflammation in animal models of traumatic brain injury. J Neurosci Methods. 272:38–49. 2016.PubMed/NCBI View Article : Google Scholar

10 

Maas AI, Roozenbeek B and Manley GT: Clinical trials in traumatic brain injury: Past experience and current developments. Neurotherapeutics. 7:115–126. 2010.PubMed/NCBI View Article : Google Scholar

11 

Koh PO: Melatonin regulates the calcium-buffering proteins, parvalbumin and hippocalcin, in ischemic brain injury. J Pineal Res. 53:358–365. 2012.PubMed/NCBI View Article : Google Scholar

12 

Ding K, Wang H, Xu J, Li T, Zhang L, Ding Y, Zhu L, He J and Zhou M: Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: The Nrf2-ARE signaling pathway as a potential mechanism. Free Radic Biol Med. 73:1–11. 2014.PubMed/NCBI View Article : Google Scholar

13 

Wang Z, Ma C, Meng CJ, Zhu GQ, Sun XB, Huo L, Zhang J, Liu HX, He WC, Shen XM, et al: Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J Pineal Res. 53:129–137. 2012.PubMed/NCBI View Article : Google Scholar

14 

Osier N, McGreevy E, Pham L, Puccio A, Ren D, Conley YP, Alexander S and Dixon CE: Melatonin as a therapy for traumatic brain injury: A review of published evidence. Int J Mol Sci. 19(1539)2018.PubMed/NCBI View Article : Google Scholar

15 

Rehman SU, Ikram M, Ullah N, Alam SI, Park HY, Badshah H, Choe K and Kim MO: Neurological Enhancement effects of melatonin against brain injury-induced oxidative stress, neuroinflammation, and neurodegeneration via AMPK/CREB signaling. Cells. 8(760)2019.PubMed/NCBI View Article : Google Scholar

16 

Cheung RT, Tipoe GL, Tam S, Ma ES, Zou LY and Chan PS: Preclinical evaluation of pharmacokinetics and safety of melatonin in propylene glycol for intravenous administration. J Pineal Res. 41:337–343. 2006.PubMed/NCBI View Article : Google Scholar

17 

Kaur C, Sivakumar V, Robinson R, Foulds WS, Luu CD and Ling EA: Neuroprotective effect of melatonin against hypoxia-induced retinal ganglion cell death in neonatal rats. J Pineal Res. 54:190–206. 2013.PubMed/NCBI View Article : Google Scholar

18 

Zyuz'kov GN, Miroshnichenko LA, Polyakova TY, Stavrova LA, Simanina EV, Agafonov VI and Zhdanov VV: Participation of cAMP/PKA-Mediated signaling pathways in functional activity of regeneration-competent cells in the nervous tissue under conditions of ethanol-induced neurodegeneration. Bull Exp Biol Med. 167:723–727. 2019.PubMed/NCBI View Article : Google Scholar

19 

Gao X, Zhang X, Cui L, Chen R, Zhang C, Xue J, Zhang L, He W, Li J, Wei S, et al: Ginsenoside Rb1 promotes motor functional recovery and axonal regeneration in post-stroke mice through cAMP/PKA/CREB signaling pathway. Brain Res Bull. 154:51–60. 2020.PubMed/NCBI View Article : Google Scholar

20 

Ye J, Yin Y, Liu H, Fang L, Tao X, Wei L, Zuo Y, Yin Y, Ke D and Wang JZ: Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging Cell. 19(e13055)2020.PubMed/NCBI View Article : Google Scholar

21 

Ma CL, Li L, Yang GM, Zhang ZB, Zhao YN, Zeng XF, Zhang DX, Yu Y, Shi ZJ, Yan QW, et al: Neuroprotective effect of gastrodin in methamphetamine-induced apoptosis through regulating cAMP/PKA/CREB pathway in cortical neuron. Hum Exp Toxicol. 39:1118–1129. 2020.PubMed/NCBI View Article : Google Scholar

22 

Yang L, Shi LJ, Yu J and Zhang YQ: Activation of protein kinase A in the amygdala modulates anxiety-like behaviors in social defeat exposed mice. Mol Brain. 9(3)2016.PubMed/NCBI View Article : Google Scholar

23 

Sung JY, Bae JH, Lee JH, Kim YN and Kim DK: The melatonin signaling pathway in a long-term memory in vitro study. Molecules. 23(737)2018.PubMed/NCBI View Article : Google Scholar

24 

Li C, Chen T, Zhou H, Feng Y, Hoi MPM, Ma D, Zhao C, Zheng Y and Lee SMY: BHDPC is a novel neuroprotectant that provides anti-neuroinflammatory and neuroprotective effects by inactivating NF-κB and activating PKA/CREB. Front Pharmacol. 25(614)2018.PubMed/NCBI View Article : Google Scholar

25 

Ding K, Xu J, Wang H, Zhang L, Wu Y and Li T: Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice. Neurochem Int. 91:46–54. 2015.PubMed/NCBI View Article : Google Scholar

26 

Song J, Cheon SY, Lee WT, Park KA and Lee JE: PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) attenuates synaptic dysfunction and neuronal cell death following ischemic injury. Neural Plast. 2015(374520)2015.PubMed/NCBI View Article : Google Scholar

27 

Salehi F, Hosseini-Zare MS, Aghajani H, Seyedi SY, Hosseini-Zare MS and Sharifzadeh M: Effect of bucladesine, pentoxifylline, and H-89 as cyclic adenosine monophosphate analog, phosphodiesterase, and protein kinase A inhibitor on acute pain. Fundam Clin Pharmacol. 31:411–419. 2017.PubMed/NCBI View Article : Google Scholar

28 

Shishido H, Ueno M, Sato K, Matsumura M, Toyota Y, Kirino Y, Tamiya T, Kawai N and Kishimoto Y: Traumatic brain injury by weight-drop method causes transient amyloid-β deposition and acute cognitive deficits in mice. Behav Neurol. 2019(3248519)2019.PubMed/NCBI View Article : Google Scholar

29 

Oh HM, Lee JS, Kim SW, Oh YT, Kim WY, Lee SB, Cho YR, Jeon YJ, Cho JH and Son CG: Uwhangchungsimwon, A standardized herbal drug, exerts an anti-depressive effect in a social isolation stress-induced mouse model. Front Pharmacol. 10(1674)2020.PubMed/NCBI View Article : Google Scholar

30 

Kondo A, Shahpasand K, Mannix R, Qiu J, Moncaster J, Chen CH, Yao Y, Lin YM, Driver JA, Sun Y, et al: Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy. Nature. 523:431–436. 2015.PubMed/NCBI View Article : Google Scholar

31 

Tajiri N, Acosta SA, Shahaduzzaman M, Ishikawa H, Shinozuka K, Pabon M, Hernandez-Ontiveros D, Kim DW, Metcalf C, Staples M, et al: Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: Cell graft biodistribution and soluble factors in young and aged rats. J Neurosci. 34:313–326. 2014.PubMed/NCBI View Article : Google Scholar

32 

Yu S, Kaneko Y, Bae E, Stahl E, Wang Y, van Loveren H, Sanberg PR and Borlongan CV: Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits. Brain Res. 1287:157–163. 2009.PubMed/NCBI View Article : Google Scholar

33 

Chen H, Sun X, Yang X, Hou Y, Yu X, Wang Y, Wu J, Liu D, Wang H, Yu J and Yi W: Dexmedetomidine reduces ventilator-induced lung injury (VILI) by inhibiting Toll-like receptor 4 (TLR4)/nuclear factor (NF)-κB signaling pathway. Bosn J Basic Med Sci. 18:162–169. 2018.PubMed/NCBI View Article : Google Scholar

34 

Popovitz J, Mysore SP and Adwanikar H: Long-term effects of traumatic brain injury on anxiety-like behaviors in mice: Behavioral and neural correlates. Front Behav Neurosci. 13(6)2019.PubMed/NCBI View Article : Google Scholar

35 

Chitturi J, Li Y, Santhakumar V and Kannurpatti SS: Early behavioral and metabolomic change after mild to moderate traumatic brain injury in the developing brain. Neurochem Int. 120:75–86. 2018.PubMed/NCBI View Article : Google Scholar

36 

Šimić G, Tkalčić M, Vukić V, Mulc D, Španić E, Šagud M, Olucha-Bordonau FE, Vukšić M and R Hof P: Understanding emotions: Origins and roles of the amygdala. Biomolecules. 11(823)2021.PubMed/NCBI View Article : Google Scholar

37 

Herrington JD, Miller JS, Pandey J and Schultz RT: Anxiety and social deficits have distinct relationships with amygdala function in autism spectrum disorder. Soc Cogn Affect Neurosci. 11:907–914. 2016.PubMed/NCBI View Article : Google Scholar

38 

Sullivan PG, Sebastian AH and Hall ED: Therapeutic window analysis of the neuroprotective effects of cyclosporine A after traumatic brain injury. J Neurotrauma. 28:311–318. 2011.PubMed/NCBI View Article : Google Scholar

39 

Neal M and Richardson JR: Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration. Biochim Biophys Acta Mol Basis Dis. 1864:432–443. 2018.PubMed/NCBI View Article : Google Scholar

40 

Chávez CE, Oyarzún JE, Avendaño BC, Mellado LA, Inostroza CA, Alvear TF and Orellana JA: The opening of connexin 43 hemichannels alters hippocampal astrocyte function and neuronal survival in prenatally LPS-Exposed adult offspring. Front Cell Neurosci. 13(460)2019.PubMed/NCBI View Article : Google Scholar

41 

Fujita A, Yamaguchi H, Yamasaki R, Cui Y, Matsuoka Y, Yamada KI and Kira JI: Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson's disease animal model. J Neuroinflammation. 15(227)2018.PubMed/NCBI View Article : Google Scholar

42 

Witcher KG, Bray CE, Dziabis JE, McKim DB, Benner BN, Rowe RK, Kokiko-Cochran ON, Popovich PG, Lifshitz J, Eiferman DS and Godbout JP: Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation. Glia. 66:2719–2736. 2018.PubMed/NCBI View Article : Google Scholar

43 

Gao TL, Yuan XT, Yang D, Dai HL, Wang WJ, Peng X, Shao HJ, Jin ZF and Fu ZJ: Expression of HMGB1 and RAGE in rat and human brains after traumatic brain injury. J Trauma Acute Care Surg. 72:643–649. 2012.PubMed/NCBI View Article : Google Scholar

44 

Hirsch EC, Breidert T, Rousselet E, Hunot S, Hartmann A and Michel PP: The role of glial reaction and inflammation in Parkinson's disease. Ann N Y Acad Sci. 991:214–228. 2003.PubMed/NCBI View Article : Google Scholar

45 

Ley EJ, Clond MA, Singer MB, Shouhed D and Salim A: IL6 deficiency affects function after traumatic brain injury. J Surg Res. 170:253–256. 2011.PubMed/NCBI View Article : Google Scholar

46 

Baratz R, Tweedie D, Wang JY, Rubovitch V, Luo W, Hoffer BJ, Greig NH and Pick CG: Transiently lowering tumor necrosis factor-alpha synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in mice. J Neuroinflammation. 12(45)2015.PubMed/NCBI View Article : Google Scholar

47 

Xing J, Han D, Xu D, Li X and Sun L: CREB Protects against temporal lobe epilepsy associated with cognitive impairment by controlling oxidative neuronal damage. Neurodegener Dis. 19:225–237. 2019.PubMed/NCBI View Article : Google Scholar

48 

Yang Y, Ma S, Wei F, Liang G, Yang X, Huang Y, Wang J and Zou Y: Pivotal role of cAMP-PKA-CREB signaling pathway in manganese-induced neurotoxicity in PC12 cells. Environ Toxicol. 34:1052–1062. 2019.PubMed/NCBI View Article : Google Scholar

49 

Ciani E, Guidi S, Della Valle G, Perini G, Bartesaghi R and Contestabile A: Withdrawal: Nitric oxide protects neuroblastoma cells from apoptosis induced by serum deprivation through cAMP-response element-binding protein (CREB) activation. J Biol Chem. 295(3391)2020.PubMed/NCBI View Article : Google Scholar

50 

Purves GI, Kamishima T, Davies LM, Quayle JM and Dart C: Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. J Physiol. 587:3639–3650. 2009.PubMed/NCBI View Article : Google Scholar

51 

Aesoy R, Muwonge H, Asrud KS, Sabir M, Witsoe SL, Bjornstad R, Kopperud RK, Hoivik EA, Doskeland SO and Bakke M: Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PLoS One. 13(e0200935)2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie L, Li S, Fan Y, Qi M and Li Z: Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway. Exp Ther Med 23: 248, 2022.
APA
Xie, L., Li, S., Fan, Y., Qi, M., & Li, Z. (2022). Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway. Experimental and Therapeutic Medicine, 23, 248. https://doi.org/10.3892/etm.2022.11173
MLA
Xie, L., Li, S., Fan, Y., Qi, M., Li, Z."Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway". Experimental and Therapeutic Medicine 23.4 (2022): 248.
Chicago
Xie, L., Li, S., Fan, Y., Qi, M., Li, Z."Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway". Experimental and Therapeutic Medicine 23, no. 4 (2022): 248. https://doi.org/10.3892/etm.2022.11173
Copy and paste a formatted citation
x
Spandidos Publications style
Xie L, Li S, Fan Y, Qi M and Li Z: Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway. Exp Ther Med 23: 248, 2022.
APA
Xie, L., Li, S., Fan, Y., Qi, M., & Li, Z. (2022). Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway. Experimental and Therapeutic Medicine, 23, 248. https://doi.org/10.3892/etm.2022.11173
MLA
Xie, L., Li, S., Fan, Y., Qi, M., Li, Z."Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway". Experimental and Therapeutic Medicine 23.4 (2022): 248.
Chicago
Xie, L., Li, S., Fan, Y., Qi, M., Li, Z."Melatonin alleviates traumatic brain injury‑induced anxiety‑like behaviors in rats: Roles of the protein kinase A/cAMP‑response element binding signaling pathway". Experimental and Therapeutic Medicine 23, no. 4 (2022): 248. https://doi.org/10.3892/etm.2022.11173
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team