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Review

New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review)

  • Authors:
    • Aida Petca
    • Ruxandra Diana Sinescu
    • Florica Sandru
    • Razvan-Cosmin Petca
    • Mihai Cristian Dumitrascu
    • Claudia Mehedintu
    • Mona Elena Zvanca
  • View Affiliations / Copyright

    Affiliations: Deparment of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Plastic Surgery and Reconstructive Microsurgery, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
  • Article Number: 270
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    Published online on: February 8, 2022
       https://doi.org/10.3892/etm.2022.11196
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Abstract

Preeclampsia (PE), a complication of pregnancy that is characterized by de novo hypertension and proteinuria, remains a leading cause of morbidity and mortality during pregnancy, influencing 2.5-7% of singleton and 7-21% of twin pregnancies. At present, diagnosis is based on traditional but unreliable and nonspecific clinical markers, and treatment of PE is suboptimal, with minimal effect on maternal and fetal mortality and morbidity. With the hope of developing an affordable and simple procedure for PE prediction for developing countries, a previous study examined the use of Congo red staining of misfolded and damaged proteins in the urine of women with PE. This feature has diagnostic and prognostic potential since it precedes the onset of clinical manifestations and correlates with disease severity. The test is inexpensive, popular within the medical staff, easy to use, and identifies women with PE in only 3 min. Obstetrical providers benefit from the Congo Red Dot Paper Test analysis, since a negative result promotes lesser waiting times in triage, prevents unneeded admissions, and diminishes the health costs associated per case.
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Copy and paste a formatted citation
Spandidos Publications style
Petca A, Sinescu RD, Sandru F, Petca R, Dumitrascu MC, Mehedintu C and Zvanca ME: New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review). Exp Ther Med 23: 270, 2022.
APA
Petca, A., Sinescu, R.D., Sandru, F., Petca, R., Dumitrascu, M.C., Mehedintu, C., & Zvanca, M.E. (2022). New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review). Experimental and Therapeutic Medicine, 23, 270. https://doi.org/10.3892/etm.2022.11196
MLA
Petca, A., Sinescu, R. D., Sandru, F., Petca, R., Dumitrascu, M. C., Mehedintu, C., Zvanca, M. E."New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review)". Experimental and Therapeutic Medicine 23.4 (2022): 270.
Chicago
Petca, A., Sinescu, R. D., Sandru, F., Petca, R., Dumitrascu, M. C., Mehedintu, C., Zvanca, M. E."New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review)". Experimental and Therapeutic Medicine 23, no. 4 (2022): 270. https://doi.org/10.3892/etm.2022.11196
Copy and paste a formatted citation
x
Spandidos Publications style
Petca A, Sinescu RD, Sandru F, Petca R, Dumitrascu MC, Mehedintu C and Zvanca ME: New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review). Exp Ther Med 23: 270, 2022.
APA
Petca, A., Sinescu, R.D., Sandru, F., Petca, R., Dumitrascu, M.C., Mehedintu, C., & Zvanca, M.E. (2022). New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review). Experimental and Therapeutic Medicine, 23, 270. https://doi.org/10.3892/etm.2022.11196
MLA
Petca, A., Sinescu, R. D., Sandru, F., Petca, R., Dumitrascu, M. C., Mehedintu, C., Zvanca, M. E."New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review)". Experimental and Therapeutic Medicine 23.4 (2022): 270.
Chicago
Petca, A., Sinescu, R. D., Sandru, F., Petca, R., Dumitrascu, M. C., Mehedintu, C., Zvanca, M. E."New approaches in predicting and diagnosing preeclampsia: Congo Red Dot Paper Test (Review)". Experimental and Therapeutic Medicine 23, no. 4 (2022): 270. https://doi.org/10.3892/etm.2022.11196
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