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Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

  • Authors:
    • Mihaela Jana Tuculina
    • Paula Perlea
    • Mircea Gheorghiță
    • Cristian Niky Cumpătă
    • Ionela Teodora Dascălu
    • Adina Turcu
    • Andreea Gabriela Nicola
    • Lelia Mihaela Gheorghiță
    • Oana Andreea Diaconu
    • Ana Valea
    • Adina Ghemigian
    • Mara Carsote
  • View Affiliations / Copyright

    Affiliations: Department of Orthodontics, Faculty of Dental Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Endodontology, Faculty of Dental Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Faculty of Dental Medicine, ‘Titu Maiorescu’ University of Bucharest, 031593 Bucharest, Romania, Departement of Endocrinology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400337 Cluj‑Napoca, Romania, Department of Endocrinology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
  • Article Number: 288
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    Published online on: February 16, 2022
       https://doi.org/10.3892/etm.2022.11217
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Abstract

Various plasticizers and nanomaterials have been linked to endocrine disruptors or endocrine‑disrupting chemicals (EDCs) which represent a large, heterogeneous, yet incompletely understood group of structures acting on normal and pathological body pathways such as hormonal production, secretion, transport and receptor binding. By contrast, various applications of nanoparticles are currently under investigation since the delivery of useful drugs, particularly insulin in diabetes mellitus, is essential in case of insulin deficiency. The aim of the present review was to introduce and examine different plasticizers and nanomaterials with potential applications for diabetic patients (such as selenium or gold‑based nanoparticles that help the oral delivery of insulin) or plasticizers/nanomaterials acting similarly to EDCs in relation to the human and animal body, particularly glucose metabolism impairment such as diabetes mellitus (DM). Bisphenol A is a chemical used worldwide; however, the effect of exposure varies with regard to the source, environment, time of exposure and the age of the organism. Daily exposure is mostly related to food and drinks stored in polycarbonate plastics. However, exposure may also be through the skin or through the maternal placenta or breast milk which are risk factors for the fetus and for the newborn. It exerts an estrogen‑like profile, but it also induces insulin resistance by impairing peripheral insulin receptors or it decreases insulin secretion by acting at the level of insulin‑secreting pancreatic β‑cells. Phthalates, compounds of flexible plastics, act as EDCs via their human metabolites such as diethyl phthalate and derivative monoethyl phthalate. Their role in inducing gestational DM and weight gain/obesity during pregnancy has been showcased. The vast field of plasticizers and nanomolecules acting as endocrine disruptors is widely linked to clinical aspects of DM, a serious condition with a major population impact. The importance of understanding and using these agents and applications is reflected in saving numerous human lives.
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Copy and paste a formatted citation
Spandidos Publications style
Tuculina MJ, Perlea P, Gheorghiță M, Cumpătă CN, Dascălu IT, Turcu A, Nicola AG, Gheorghiță LM, Diaconu OA, Valea A, Valea A, et al: Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review). Exp Ther Med 23: 288, 2022.
APA
Tuculina, M.J., Perlea, P., Gheorghiță, M., Cumpătă, C.N., Dascălu, I.T., Turcu, A. ... Carsote, M. (2022). Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review). Experimental and Therapeutic Medicine, 23, 288. https://doi.org/10.3892/etm.2022.11217
MLA
Tuculina, M. J., Perlea, P., Gheorghiță, M., Cumpătă, C. N., Dascălu, I. T., Turcu, A., Nicola, A. G., Gheorghiță, L. M., Diaconu, O. A., Valea, A., Ghemigian, A., Carsote, M."Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)". Experimental and Therapeutic Medicine 23.4 (2022): 288.
Chicago
Tuculina, M. J., Perlea, P., Gheorghiță, M., Cumpătă, C. N., Dascălu, I. T., Turcu, A., Nicola, A. G., Gheorghiță, L. M., Diaconu, O. A., Valea, A., Ghemigian, A., Carsote, M."Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)". Experimental and Therapeutic Medicine 23, no. 4 (2022): 288. https://doi.org/10.3892/etm.2022.11217
Copy and paste a formatted citation
x
Spandidos Publications style
Tuculina MJ, Perlea P, Gheorghiță M, Cumpătă CN, Dascălu IT, Turcu A, Nicola AG, Gheorghiță LM, Diaconu OA, Valea A, Valea A, et al: Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review). Exp Ther Med 23: 288, 2022.
APA
Tuculina, M.J., Perlea, P., Gheorghiță, M., Cumpătă, C.N., Dascălu, I.T., Turcu, A. ... Carsote, M. (2022). Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review). Experimental and Therapeutic Medicine, 23, 288. https://doi.org/10.3892/etm.2022.11217
MLA
Tuculina, M. J., Perlea, P., Gheorghiță, M., Cumpătă, C. N., Dascălu, I. T., Turcu, A., Nicola, A. G., Gheorghiță, L. M., Diaconu, O. A., Valea, A., Ghemigian, A., Carsote, M."Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)". Experimental and Therapeutic Medicine 23.4 (2022): 288.
Chicago
Tuculina, M. J., Perlea, P., Gheorghiță, M., Cumpătă, C. N., Dascălu, I. T., Turcu, A., Nicola, A. G., Gheorghiță, L. M., Diaconu, O. A., Valea, A., Ghemigian, A., Carsote, M."Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)". Experimental and Therapeutic Medicine 23, no. 4 (2022): 288. https://doi.org/10.3892/etm.2022.11217
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