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Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway

  • Authors:
    • Wen-Xi Wang
    • Zhen-Ru Zhao
    • Ying Bai
    • Ya-Xing Li
    • Xiao-Ning Gao
    • Sen Zhang
    • Yan-Bin Sun
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Chengde Central Hospital, Chengde, Hebei 067000, P.R. China, State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 303
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    Published online on: February 22, 2022
       https://doi.org/10.3892/etm.2022.11232
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Abstract

Oxidative stress, caused by renal ischemia reperfusion (IR)/hypoperfusion, is one of the main causes of acute kidney injury (AKI). Previous studies have demonstrated that sevoflurane (SEV) protects organs from the damage caused by oxidative stress. In the present study, mice were randomly assigned to a sham operation group (Sham), IR‑vehicle group (IR+ vehicle), IR + SEV low‑dose preconditioning group and an IR + SEV high‑dose preconditioning group. The effect of SEV on nuclear factor E2‑related factor 2 (Nrf2), a key regulatory protein of the endogenous antioxidant defense system and, consequently oxidative stress, inflammation and apoptosis‑related factors, were all quantified using commercial kits or by western blotting. SEV preconditioning was demonstrated to ameliorate kidney injury as a result of decreased blood urine nitrogen and serum creatinine levels, activated Nrf2 expression in the kidney and decreased oxidative stress and inflammatory index levels an AKI mouse model. SEV preconditioning also protected injured kidney via the downregulation of caspase‑3 protein expression levels. In addition, using the Nrf2 inhibitor, Brusatol, significantly abolished the SEV preconditioning renal protective effect. Using an in vitro HK‑2 cell model of hypoxia/reoxygenation, it was also demonstrated that Nrf2 pathway activation was necessary for SEV to exert its beneficial effect for tubular cell injury caused by hypoxia/reoxygenation. These results indicated that SEV may protect against renal injury caused by IR via Nrf2 upregulation.
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1 

Verma S and Kellum JA: Defining acute kidney injury. Crit Care Clin. 37:251–266. 2021.PubMed/NCBI View Article : Google Scholar

2 

Bidani A and Churchill PC: Acute renal failure. Dis Mon. 35:57–132. 1989.PubMed/NCBI View Article : Google Scholar

3 

Kulvichit W, Kellum JA and Srisawat N: Biomarkers in acute kidney injury. Crit Care Clin. 37:385–398. 2021.PubMed/NCBI View Article : Google Scholar

4 

Yang L, Xing G, Wang L, Wu Y, Li S, Xu G, He Q, Chen J, Chen M, Liu X, et al: Acute kidney injury in China: A cross-sectional survey. Lancet. 386:1465–1471. 2015.PubMed/NCBI View Article : Google Scholar

5 

Hilton R: Acute renal failure. BMJ. 333:786–790. 2006.PubMed/NCBI View Article : Google Scholar

6 

Han SJ and Lee HT: Mechanisms and therapeutic targets of ischemic acute kidney injury. Kidney Res Clin Pract. 38:427–440. 2019.PubMed/NCBI View Article : Google Scholar

7 

Jan R and Chaudhry GE: Understanding apoptosis and apoptotic pathways targeted cancer therapeutics. Adv Pharm Bull. 9:205–218. 2019.PubMed/NCBI View Article : Google Scholar

8 

Chatterjee PK, Todorovic Z, Sivarajah A, Mota-Filipe H, Brown PA, Stewart KN, Cuzzocrea S and Thiemermann C: Differential effects of caspase inhibitors on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney. Eur J Pharmacol. 503:173–183. 2004.PubMed/NCBI View Article : Google Scholar

9 

Xiao Z, Shan J, Li C, Luo L, Lu J, Li S, Long D and Li Y: Mechanisms of cyclosporine-induced renal cell apoptosis: A systematic review. Am J Nephrol. 37:30–40. 2013.PubMed/NCBI View Article : Google Scholar

10 

Wu TJ, Hsieh YJ, Lu CW, Lee CJ and Hsu BG: Linagliptin protects against endotoxin-induced acute kidney injury in rats by decreasing inflammatory cytokines and reactive oxygen species. Int J Mol Sci. 22(11190)2021.PubMed/NCBI View Article : Google Scholar

11 

Vomund S, Schäfer A, Parnham MJ, Brüne B and von Knethen A: Nrf2, the master regulator of anti-oxidative responses. Int J Mol Sci. 18(2772)2017.PubMed/NCBI View Article : Google Scholar

12 

Abdo S, Zhang SL and Chan JS: Reactive oxygen species and nuclear factor erythroid 2-related factor 2 activation in diabetic nephropathy: A hidden target. J Diabetes Metab 6: 10.4172/2155-6156.1000547, 2015.

13 

Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S and Yamamoto M: Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 275:16023–16029. 2000.PubMed/NCBI View Article : Google Scholar

14 

Bolignano D, Donato V, Coppolino G, Campo S, Buemi A, Lacquaniti A and Buemi M: Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis. 52:595–605. 2008.PubMed/NCBI View Article : Google Scholar

15 

Rhee H, Shin N, Shin MJ, Yang BY, Kim IY, Song SH, Lee DW, Lee SB, Kwak IS and Seong EY: High serum and urine neutrophil gelatinase-associated lipocalin levels are independent predictors of renal progression in patients with immunoglobulin A nephropathy. Korean J Intern Med. 30:354–361. 2015.PubMed/NCBI View Article : Google Scholar

16 

Albert C, Zapf A, Haase M, Röver C, Pickering JW, Albert A, Bellomo R, Breidthardt T, Camou F, Chen Z, et al: Neutrophil gelatinase-associated lipocalin measured on clinical laboratory platforms for the prediction of acute kidney injury and the associated need for dialysis therapy: A systematic review and meta-analysis. Am J Kidney Dis. 76:826–841.e1. 2020.PubMed/NCBI View Article : Google Scholar

17 

Naunova-Timovska S, Cekovska S, Sahpazova E and Tasić V: Neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in newborns. Acta Clin Croat. 59:55–62. 2020.PubMed/NCBI View Article : Google Scholar

18 

Albeladi FI and Algethamy HM: Urinary neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury, severe kidney injury, and the need for renal replacement therapy in the intensive care unit. Nephron Extra. 7:62–77. 2017.PubMed/NCBI View Article : Google Scholar

19 

Jose RL, Damayanathi D, Unnikrishnan KP and Suneel PR: A comparison of sevoflurane versus sevoflurane-propofol combination on renal function in patients undergoing valvular heart surgery-A prospective randomized controlled pilot study. Ann Card Anaesth. 24:172–177. 2021.PubMed/NCBI View Article : Google Scholar

20 

Li H, Weng Y, Yuan S, Liu W, Yu H and Yu W: Effect of sevoflurane and propofol on acute kidney injury in pediatric living donor liver transplantation. Ann Transl Med. 7(340)2019.PubMed/NCBI View Article : Google Scholar

21 

Ministry of Science and Technology of the PRC. Available from: https://www.puh3.net.cn/images/dwsyzx/zc/2020/5/30/227A82A9E2B44976986A1EB84BB39836.pdf.

22 

Zhang S, Xin H, Li Y, Zhang D, Shi J, Yang J and Chen X: Skimmin, a coumarin from hydrangea paniculata, slows down the progression of membranous glomerulonephritis by anti-inflammatory effects and inhibiting immune complex deposition. Evid Based Complement Alternat Med. 2013(819296)2013.PubMed/NCBI View Article : Google Scholar

23 

Zhang S, Ma J, Sheng L, Zhang D, Chen X, Yang J and Wang D: Total coumarins from hydrangea paniculata show renal protective effects in lipopolysaccharide-induced acute kidney injury via anti-inflammatory and antioxidant activities. Front Pharmacol. 8(872)2017.PubMed/NCBI View Article : Google Scholar

24 

Han SJ, Kim JH, Kim JI and Park KM: Inhibition of microtubule dynamics impedes repair of kidney ischemia/reperfusion injury and increases fibrosis. Sci Rep. 6(27775)2016.PubMed/NCBI View Article : Google Scholar

25 

Gonul Y, Ozsoy M, Kocak A, Ozkececi ZT, Karavelioglu A, Bozkurt MF, Cartilli O, Keles I, Kocak H and Celik S: Antioxidant, antiapoptotic and inflammatory effects of interleukin-18 binding protein on kidney damage induced by hepatic ischemia reperfusion. Am J Med Sci. 351:607–615. 2016.PubMed/NCBI View Article : Google Scholar

26 

Linas SL, Whittenburg D and Repine JE: Role of xanthine oxidase in ischemia/reperfusion injury. Am J Physiol. 258:F711–F716. 1990.PubMed/NCBI View Article : Google Scholar

27 

Granger DN and Kvietys PR: Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol. 6:524–551. 2015.PubMed/NCBI View Article : Google Scholar

28 

Granger DN, Rutili G and McCord JM: Superoxide radicals in feline intestinal ischemia. Gastroenterology. 81:22–29. 1981.PubMed/NCBI

29 

Nuñez G, Benedict MA, Hu Y and Inohara N: Caspases: The proteases of the apoptotic pathway. Oncogene. 17:3237–3245. 1998.PubMed/NCBI View Article : Google Scholar

30 

Ighodaro OM and Akinloye OA: First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alex J Med. 54:287–293. 2018.

31 

Silva-Islas CA and Maldonado PD: Canonical and non-canonical mechanisms of Nrf2 activation. Pharmacol Res. 134:92–99. 2018.PubMed/NCBI View Article : Google Scholar

32 

Loboda A, Damulewicz M, Pyza E, Jozkowicz A and Dulak J: Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: An evolutionarily conserved mechanism. Cell Mol Life Sci. 73:3221–3247. 2016.PubMed/NCBI View Article : Google Scholar

33 

Ruan H, Luo J, Wang L, Wang J, Wang Z and Zhang J: Sika deer antler protein against acetaminophen-induced nephrotoxicity by activating Nrf2 and inhibition FoxO1 via PI3K/Akt signaling. Int J Biol Macromol. 141:961–987. 2019.PubMed/NCBI View Article : Google Scholar

34 

Meng XM, Nikolic-Paterson DJ and Lan HY: Inflammatory processes in renal fibrosis. Nat Rev Nephrol. 10:493–503. 2014.PubMed/NCBI View Article : Google Scholar

35 

Sun L and Kanwar YS: Relevance of TNF-α in the context of other inflammatory cytokines in the progression of diabetic nephropathy. Kidney Int. 88:662–665. 2015.PubMed/NCBI View Article : Google Scholar

36 

Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ and Lichtman AH: IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol. 188:6287–6299. 2012.PubMed/NCBI View Article : Google Scholar

37 

Tanaka T, Narazaki M and Kishimoto T: IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol. 6(a016295)2014.PubMed/NCBI View Article : Google Scholar

38 

Neag MA, Mitre AO, Catinean A and Mitre CI: An overview on the mechanisms of neuroprotection and neurotoxicity of isoflurane and sevoflurane in experimental studies. Brain Res Bull. 165:281–289. 2020.PubMed/NCBI View Article : Google Scholar

39 

Fang FQ, Sun JH, Wu QL, Feng LY, Fan YX, Ye JX, Gao W, He GL and Wang WJ: Protective effect of sevoflurane on vascular endothelial glycocalyx in patients undergoing heart valve surgery: A randomised controlled trial. Eur J Anaesthesiol. 38:477–486. 2021.PubMed/NCBI View Article : Google Scholar

40 

Sen Z, Jie M, Jingzhi Y, Dongjie W, Dongming Z and Xiaoguang C: Total coumarins from hydrangea paniculata protect against cisplatin-induced acute kidney damage in mice by suppressing renal inflammation and apoptosis. Evid Based Complement Alternat Med. 2017(5350161)2017.PubMed/NCBI View Article : Google Scholar

41 

Chung CH, Fan J, Lee EY, Kang JS, Lee SJ, Pyagay PE, Khoury CC, Yeo TK, Khayat MF, Wang A and Chen S: Effects of tumor necrosis factor-α on podocyte expression of monocyte chemoattractant protein-1 and in diabetic nephropathy. Nephron Extra. 5:1–18. 2015.PubMed/NCBI View Article : Google Scholar

42 

Haller H, Bertram A, Nadrowitz F and Menne J: Monocyte chemoattractant protein-1 and the kidney. Curr Opin Nephrol Hypertens. 25:42–49. 2016.PubMed/NCBI View Article : Google Scholar

43 

Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR and Girkontaite I: Immunosuppressive effects of apoptotic cells. Nature. 390:350–351. 1997.PubMed/NCBI View Article : Google Scholar

44 

Fadok VA, Bratton DL, Konowal A, Freed PW, Westcott JY and Henson PM: Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest. 101:890–898. 1998.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang W, Zhao Z, Bai Y, Li Y, Gao X, Zhang S and Sun Y: Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway. Exp Ther Med 23: 303, 2022.
APA
Wang, W., Zhao, Z., Bai, Y., Li, Y., Gao, X., Zhang, S., & Sun, Y. (2022). Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway. Experimental and Therapeutic Medicine, 23, 303. https://doi.org/10.3892/etm.2022.11232
MLA
Wang, W., Zhao, Z., Bai, Y., Li, Y., Gao, X., Zhang, S., Sun, Y."Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway". Experimental and Therapeutic Medicine 23.4 (2022): 303.
Chicago
Wang, W., Zhao, Z., Bai, Y., Li, Y., Gao, X., Zhang, S., Sun, Y."Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway". Experimental and Therapeutic Medicine 23, no. 4 (2022): 303. https://doi.org/10.3892/etm.2022.11232
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Zhao Z, Bai Y, Li Y, Gao X, Zhang S and Sun Y: Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway. Exp Ther Med 23: 303, 2022.
APA
Wang, W., Zhao, Z., Bai, Y., Li, Y., Gao, X., Zhang, S., & Sun, Y. (2022). Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway. Experimental and Therapeutic Medicine, 23, 303. https://doi.org/10.3892/etm.2022.11232
MLA
Wang, W., Zhao, Z., Bai, Y., Li, Y., Gao, X., Zhang, S., Sun, Y."Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway". Experimental and Therapeutic Medicine 23.4 (2022): 303.
Chicago
Wang, W., Zhao, Z., Bai, Y., Li, Y., Gao, X., Zhang, S., Sun, Y."Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway". Experimental and Therapeutic Medicine 23, no. 4 (2022): 303. https://doi.org/10.3892/etm.2022.11232
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