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Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells

  • Authors:
    • Min Yi
    • Guanglei Wang
    • Jianhua Niu
    • Minghui Peng
    • Yi Liu
  • View Affiliations / Copyright

    Affiliations: Department of Integrative Therapy, Shanghai Huangpu District 2nd Dental Disease Prevention and Treatment Institute, Shanghai 200001, P.R. China, Department of Stomatology, Jiading District Central Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Shanghai 201800, P.R. China
    Copyright: © Yi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 304
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    Published online on: February 22, 2022
       https://doi.org/10.3892/etm.2022.11233
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Abstract

Periodontitis is a common chronic inflammatory oral disease. The objective of periodontal treatment is to control infection whilst regenerating damaged periodontal tissue. The present study aimed to determine the potential effects of pterostilbene (PTE), a representative stilbene compound, on the proliferation and differentiation of human periodontal ligament stem cells (hPDLSCs). Different concentrations (1, 5, 10 and 20 µM) of PTE were applied to hPDLSCs, after which Cell Counting Kit‑8 and western blotting assays were performed to examine the protein levels of Ki67, PCNA, p‑IκBα, IκBα, Bcl‑2, Bax, cleaved caspase3. The effect of PTE on the release of inflammatory factors, including IL‑1β, IL‑6 and IL‑10 was assessed by RT‑qPCR. The apoptosis of TNF‑α‑induced hPDLSCs was evaluated by TUNEL assay and western blotting. Additionally, the role of PTE in hPDLSC mineralization was evaluated using alizarin red staining. The expression levels of mineralization indices, including RUNX2 and ALP were subsequently determined using western blotting. Subsequently, the target of PTE was predicted using TargetNet database and AutoDock v4.2 software and verified using western blotting. The results of the present study revealed that PTE promoted the proliferation of hPDLSCs in a concentration‑dependent manner. Furthermore, PTE treatment decreased the release of inflammatory factors and alleviated the apoptosis of TNF‑α‑induced hPDLSCs. PTE was also demonstrated to promote the formation of mineral nodules in TNF‑α‑induced hPDLSCs. The Targetnet database, along with molecular docking, indicated that histone deacetylases (HDACs) were the probable targets of PTE upstream of regulating periodontitis. The results of western blotting implied that TNF‑α significantly increased expression levels of HDAC2, 4, 6 and 8, whilst PTE treatment markedly decreased HDAC4, 6 and 8 expression in a concentration‑dependent manner compared with the TNF‑α group, which further confirmed these conclusions. In summary, results of the present study revealed that PTE promoted TNF‑α‑induced hPDLSC proliferation and differentiation, whilst alleviating inflammation and apoptosis. PTE also inhibited the expression of HDACs, which may be involved in the mechanism of periodontitis.
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1 

Hoare A, Soto C, Rojas-Celis V and Bravo D: Chronic inflammation as a link between periodontitis and carcinogenesis. Mediators Inflamm. 2019(1029857)2019.PubMed/NCBI View Article : Google Scholar

2 

Gasner NS and Schure RS: Periodontal disease. In: StatPearls. StatPearls Publishing, Treasure Island, FL, 2021.

3 

Liu J, Ruan J, Weir MD, Ren K, Schneider A, Wang P, Oates TW, Chang X and Xu HHK: Periodontal bone-ligament-cementum regeneration via scaffolds and stem cells. Cells. 8(537)2019.PubMed/NCBI View Article : Google Scholar

4 

Graziani F, Karapetsa D, Alonso B and Herrera D: Nonsurgical and surgical treatment of periodontitis: How many options for one disease? Periodontol 2000. 75:152–188. 2017.PubMed/NCBI View Article : Google Scholar

5 

Deas DE, Moritz AJ, Sagun RS Jr, Gruwell SF and Powell CA: Scaling and root planing vs. conservative surgery in the treatment of chronic periodontitis. Periodontol 2000. 71:128–139. 2016.PubMed/NCBI View Article : Google Scholar

6 

Reynolds MA, Kao RT, Camargo PM, Caton JG, Clem DS, Fiorellini JP, Geisinger ML, Mills MP, Nares S and Nevins ML: Periodontal regeneration-intrabony defects: A consensus report from the AAP regeneration workshop. J Periodontol. 86 (Suppl 2):S105–S107. 2015.PubMed/NCBI View Article : Google Scholar

7 

Rojas MA, Marini L, Pilloni A and Sahrmann P: Early wound healing outcomes after regenerative periodontal surgery with enamel matrix derivatives or guided tissue regeneration: A systematic review. BMC Oral Health. 19(76)2019.PubMed/NCBI View Article : Google Scholar

8 

Gao F, Chiu SM, Motan DA, Zhang Z, Chen L, Ji HL, Tse HF, Fu QL and Lian Q: Mesenchymal stem cells and immunomodulation: Current status and future prospects. Cell Death Dis. 7(e2062)2016.PubMed/NCBI View Article : Google Scholar

9 

Moradi SL, Golchin A, Hajishafieeha Z, Khani MM and Ardeshirylajimi A: Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds. J Cell Physiol. 233:6509–6522. 2018.PubMed/NCBI View Article : Google Scholar

10 

Ouchi T and Nakagawa T: Mesenchymal stem cell-based tissue regeneration therapies for periodontitis. Regen Ther. 14:72–78. 2020.PubMed/NCBI View Article : Google Scholar

11 

Yoshida T, Washio K, Iwata T, Okano T and Ishikawa I: Current status and future development of cell transplantation therapy for periodontal tissue regeneration. Int J Dent. 2012(307024)2012.PubMed/NCBI View Article : Google Scholar

12 

Huang GT, Gronthos S and Shi S: Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in regenerative medicine. J Dent Res. 88:792–806. 2009.PubMed/NCBI View Article : Google Scholar

13 

Pecyna P, Wargula J, Murias M and Kucinska M: More than resveratrol: New insights into stilbene-based compounds. Biomolecules. 10(1111)2020.PubMed/NCBI View Article : Google Scholar

14 

Cassiano C, Eletto D, Tosco A, Riccio R, Monti MC and Casapullo A: Determining the effect of pterostilbene on insulin secretion using chemoproteomics. Molecules. 25(2885)2020.PubMed/NCBI View Article : Google Scholar

15 

Kim H, Seo KH and Yokoyama W: Chemistry of pterostilbene and its metabolic effects. J Agric Food Chem. 68:12836–12841. 2020.PubMed/NCBI View Article : Google Scholar

16 

Lange KW and Li S: Resveratrol, pterostilbene, and dementia. Biofactors. 44:83–90. 2018.PubMed/NCBI View Article : Google Scholar

17 

Ma Z, Zhang X, Xu L, Liu D, Di S, Li W, Zhang J, Zhang H, Li X, Han J and Yan X: Pterostilbene: Mechanisms of its action as oncostatic agent in cell models and in vivo studies. Pharmacol Res. 145(104265)2019.PubMed/NCBI View Article : Google Scholar

18 

Guo Y, Zhang L, Li F, Hu CP and Zhang Z: Restoration of sirt1 function by pterostilbene attenuates hypoxia-reoxygenation injury in cardiomyocytes. Eur J Pharmacol. 776:26–33. 2016.PubMed/NCBI View Article : Google Scholar

19 

Wu M, Lu S, Zhong J, Huang K and Zhang S: Protective effects of pterostilbene against myocardial ischemia/reperfusion injury in rats. Inflammation. 40:578–588. 2017.PubMed/NCBI View Article : Google Scholar

20 

Zhang Y and Zhang Y: Pterostilbene, a novel natural plant conduct, inhibits high fat-induced atherosclerosis inflammation via NF-κB signaling pathway in Toll-like receptor 5 (TLR5) deficient mice. Biomed Pharmacother. 81:345–355. 2016.PubMed/NCBI View Article : Google Scholar

21 

Lim YRI, Preshaw PM, Lim LP, Ong MMA, Lin HS and Tan KS: Pterostilbene complexed with cyclodextrin exerts antimicrobial and anti-inflammatory effects. Sci Rep. 10(9072)2020.PubMed/NCBI View Article : Google Scholar

22 

Kitaura H, Kimura K, Ishida M, Kohara H, Yoshimatsu M and Takano-Yamamoto T: Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo. Clin Dev Immunol. 2013(181849)2013.PubMed/NCBI View Article : Google Scholar

23 

Liu H, Wu X, Luo J, Wang X, Guo H, Feng D, Zhao L, Bai H, Song M, Liu X, et al: Pterostilbene attenuates astrocytic inflammation and neuronal oxidative injury after ischemia-reperfusion by inhibiting NF-κB phosphorylation. Front Immunol. 10(2408)2019.PubMed/NCBI View Article : Google Scholar

24 

Meng T, Zhou Y, Li J, Hu M, Li X, Wang P, Jia Z, Li L and Liu D: Azithromycin promotes the osteogenic differentiation of human periodontal ligament stem cells after stimulation with TNF-α. Stem Cells Int. 2018(7961962)2018.PubMed/NCBI View Article : Google Scholar

25 

Yao ZJ, Dong J, Che YJ, Zhu MF, Wen M, Wang NN, Wang S, Lu AP and Cao DS: TargetNet: A web service for predicting potential drug-target interaction profiling via multi-target SAR models. J Comput Aided Mol Des. 30:413–424. 2016.PubMed/NCBI View Article : Google Scholar

26 

Li J, Fu A and Zhang L: An overview of scoring functions used for protein-ligand interactions in molecular docking. Interdiscip Sci. 11:320–328. 2019.PubMed/NCBI View Article : Google Scholar

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

28 

Xia Y, Tang HN, Wu RX, Yu Y, Gao LN and Chen FM: Cell responses to conditioned media produced by patient-matched stem cells derived from healthy and inflamed periodontal ligament tissues. J Periodontol. 87:e53–e63. 2016.PubMed/NCBI View Article : Google Scholar

29 

Chen FM, Sun HH, Lu H and Yu Q: Stem cell-delivery therapeutics for periodontal tissue regeneration. Biomaterials. 33:6320–6344. 2012.PubMed/NCBI View Article : Google Scholar

30 

Pizzicannella J, Gugliandolo A, Orsini T, Fontana A, Ventrella A, Mazzon E, Bramanti P, Diomede F and Trubiani O: Engineered extracellular vesicles from human periodontal-ligament stem cells increase VEGF/VEGFR2 expression during bone regeneration. Front Physiol. 10(512)2019.PubMed/NCBI View Article : Google Scholar

31 

Bright R, Hynes K, Gronthos S and Bartold PM: Periodontal ligament-derived cells for periodontal regeneration in animal models: A systematic review. J Periodontal Res. 50:160–172. 2015.PubMed/NCBI View Article : Google Scholar

32 

Zhang Y, Xing Y, Jia L, Ji Y, Zhao B, Wen Y and Xu X: An in vitro comparative study of multisource derived human mesenchymal stem cells for bone tissue engineering. Stem Cells Dev. 27:1634–1645. 2018.PubMed/NCBI View Article : Google Scholar

33 

Trubiani O, Pizzicannella J, Caputi S, Marchisio M, Mazzon E, Paganelli R, Paganelli A and Diomede F: Periodontal ligament stem cells: Current knowledge and future perspectives. Stem Cells Dev. 28:995–1003. 2019.PubMed/NCBI View Article : Google Scholar

34 

Fang D and Zhu J: Molecular switches for regulating the differentiation of inflammatory and IL-10-producing anti-inflammatory T-helper cells. Cell Mol Life Sci. 77:289–303. 2020.PubMed/NCBI View Article : Google Scholar

35 

Munshi S, Parrilli V and Rosenkranz JA: Peripheral anti-inflammatory cytokine Interleukin-10 treatment mitigates interleukin-1β-induced anxiety and sickness behaviors in adult male rats. Behav Brain Res. 372(112024)2019.PubMed/NCBI View Article : Google Scholar

36 

Ng A, Tam WW, Zhang MW, Ho CS, Husain SF, McIntyre RS and Ho RC: IL-1β, IL-6, TNF-α and CRP in elderly patients with depression or Alzheimer's disease: Systematic review and meta-analysis. Sci Rep. 8(12050)2018.PubMed/NCBI View Article : Google Scholar

37 

Yang H, Hua C, Yang X, Fan X, Song H, Peng L and Ci X: Pterostilbene prevents LPS-induced early pulmonary fibrosis by suppressing oxidative stress, inflammation and apoptosis in vivo. Food Funct. 11:4471–4484. 2020.PubMed/NCBI View Article : Google Scholar

38 

Newton AH and Pask AJ: CHD9 upregulates RUNX2 and has a potential role in skeletal evolution. BMC Mol Cell Biol. 21(27)2020.PubMed/NCBI View Article : Google Scholar

39 

Jin H, Park JY, Choi H and Choung PH: HDAC inhibitor trichostatin A promotes proliferation and odontoblast differentiation of human dental pulp stem cells. Tissue Eng Part A. 19:613–624. 2013.PubMed/NCBI View Article : Google Scholar

40 

Liu Z, Chen T, Han Q, Chen M, You J, Fang F, Peng L and Wu B: HDAC inhibitor LMK-235 promotes the odontoblast differentiation of dental pulp cells. Mol Med Rep. 17:1445–1452. 2018.PubMed/NCBI View Article : Google Scholar

41 

Algate K, Haynes D, Fitzsimmons T, Romeo O, Wagner F, Holson E, Reid R, Fairlie D, Bartold P and Cantley M: Histone deacetylases 1 and 2 inhibition suppresses cytokine production and osteoclast bone resorption in vitro. J Cell Biochem. 121:244–258. 2020.PubMed/NCBI View Article : Google Scholar

42 

Yan GQ, Wang X, Yang F, Yang ML, Zhang GR, Wang GK and Zhou Q: MicroRNA-22 promoted osteogenic differentiation of human periodontal ligament stem cells by targeting HDAC6. J Cell Biochem. 118:1653–1658. 2017.PubMed/NCBI View Article : Google Scholar

43 

Leonova K, Safina A, Nesher E, Sandlesh P, Pratt R, Burkhart C, Lipchick B, Gitlin I, Frangou C, Koman I, et al: TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells. Elife. 7(e30842)2018.PubMed/NCBI View Article : Google Scholar

44 

Elmer JJ, Christensen MD, Barua S, Lehrman J, Haynes KA and Rege K: The histone deacetylase inhibitor entinostat enhances polymer-mediated transgene expression in cancer cell lines. Biotechnol Bioeng. 113:1345–1356. 2016.PubMed/NCBI View Article : Google Scholar

45 

Liao XH, Lu DL, Wang N, Liu LY, Wang Y, Li YQ, Yan TB, Sun XG, Hu P and Zhang TC: Estrogen receptor α mediates proliferation of breast cancer MCF-7 cells via a p21/PCNA/E2F1-dependent pathway. FEBS J. 281:927–942. 2014.PubMed/NCBI View Article : Google Scholar

46 

Zhang Q, Zuo H, Yu S, Lin Y, Chen S, Liu H and Chen Z: RUNX2 co-operates with EGR1 to regulate osteogenic differentiation through Htra1 enhancers. J Cell Physiol. 235:8601–8612. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yi M, Wang G, Niu J, Peng M and Liu Y: Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells. Exp Ther Med 23: 304, 2022.
APA
Yi, M., Wang, G., Niu, J., Peng, M., & Liu, Y. (2022). Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells. Experimental and Therapeutic Medicine, 23, 304. https://doi.org/10.3892/etm.2022.11233
MLA
Yi, M., Wang, G., Niu, J., Peng, M., Liu, Y."Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells". Experimental and Therapeutic Medicine 23.4 (2022): 304.
Chicago
Yi, M., Wang, G., Niu, J., Peng, M., Liu, Y."Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells". Experimental and Therapeutic Medicine 23, no. 4 (2022): 304. https://doi.org/10.3892/etm.2022.11233
Copy and paste a formatted citation
x
Spandidos Publications style
Yi M, Wang G, Niu J, Peng M and Liu Y: Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells. Exp Ther Med 23: 304, 2022.
APA
Yi, M., Wang, G., Niu, J., Peng, M., & Liu, Y. (2022). Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells. Experimental and Therapeutic Medicine, 23, 304. https://doi.org/10.3892/etm.2022.11233
MLA
Yi, M., Wang, G., Niu, J., Peng, M., Liu, Y."Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells". Experimental and Therapeutic Medicine 23.4 (2022): 304.
Chicago
Yi, M., Wang, G., Niu, J., Peng, M., Liu, Y."Pterostilbene attenuates the proliferation and differentiation of TNF‑α‑treated human periodontal ligament stem cells". Experimental and Therapeutic Medicine 23, no. 4 (2022): 304. https://doi.org/10.3892/etm.2022.11233
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