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Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells

  • Authors:
    • Seong Hee Kang
    • Dong-Ho Bak
    • Byung Yeoup Chung
    • Hyoung-Woo Bai
  • View Affiliations / Copyright

    Affiliations: Research Division for Radiation Science, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, Jeollabuk 56212, Republic of Korea
    Copyright: © Kang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 306
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    Published online on: February 23, 2022
       https://doi.org/10.3892/etm.2022.11235
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Abstract

Breast cancer is one of the most challenging diseases to treat in humans worldwide. There are several alternatives in treating this life‑threatening disease; however, chemoresistance is probably the biggest obstacle to the treatment of breast cancer. It may be essential to develop a therapeutic candidate material with less reversible effects and high treatment efficiency to solve this problem. The present study applied an ionizing radiation approach employing nomifensine (NF) to transform its chemical characteristics and investigated its potential to kill human breast cancer cells (MCF‑7). Irradiated (IR‑) NF was analyzed using high‑performance liquid chromatography. The findings showed that NF inhibited the proliferation of breast cancer cells and increased the rate of apoptosis. In addition, IR‑NF induced the accumulation of cytosolic reactive oxygen species and enhanced mitochondrial aggregation. Additionally, mitogen‑activated protein kinases (extracellular signal‑regulated kinase 1/2, p38 and c‑Jun NH 2‑terminal kinase) were involved in damage signaling induced by IR‑NF and IR‑NF suppressed β‑catenin nuclear translocation. It is suggested that irradiation can be an effective method to maximize the efficacy of existing drugs and that IR‑NF has the potential to be a drug candidate for treating patients with breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kang SH, Bak D, Chung BY and Bai H: Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells. Exp Ther Med 23: 306, 2022.
APA
Kang, S.H., Bak, D., Chung, B.Y., & Bai, H. (2022). Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells. Experimental and Therapeutic Medicine, 23, 306. https://doi.org/10.3892/etm.2022.11235
MLA
Kang, S. H., Bak, D., Chung, B. Y., Bai, H."Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells". Experimental and Therapeutic Medicine 23.4 (2022): 306.
Chicago
Kang, S. H., Bak, D., Chung, B. Y., Bai, H."Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells". Experimental and Therapeutic Medicine 23, no. 4 (2022): 306. https://doi.org/10.3892/etm.2022.11235
Copy and paste a formatted citation
x
Spandidos Publications style
Kang SH, Bak D, Chung BY and Bai H: Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells. Exp Ther Med 23: 306, 2022.
APA
Kang, S.H., Bak, D., Chung, B.Y., & Bai, H. (2022). Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells. Experimental and Therapeutic Medicine, 23, 306. https://doi.org/10.3892/etm.2022.11235
MLA
Kang, S. H., Bak, D., Chung, B. Y., Bai, H."Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells". Experimental and Therapeutic Medicine 23.4 (2022): 306.
Chicago
Kang, S. H., Bak, D., Chung, B. Y., Bai, H."Transformation of nomifensine using ionizing radiation and exploration of its anticancer effects in MCF‑7 cells". Experimental and Therapeutic Medicine 23, no. 4 (2022): 306. https://doi.org/10.3892/etm.2022.11235
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