Open Access

Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice

  • Authors:
    • Jing Zhu
    • Jiexia Ding
    • Siying Li
    • Jie Jin
  • View Affiliations

  • Published online on: February 24, 2022     https://doi.org/10.3892/etm.2022.11237
  • Article Number: 308
  • Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑alcoholic steatohepatitis (NASH) is becoming a huge global health problem. Previous studies have revealed that ganoderic acids have hepatoprotective and hypocholesterolemic effects. In the present study, to evaluate the anti‑NASH activity of ganoderic acid A (GAA), male 6‑week‑old C57BL/6J mice were divided into the following four groups, which were administered different diets: Normal diet (ND group), high‑fat high‑cholesterol diet (HFHC group), HFHC diet supplemented with 25 mg/kg/day (GAAL group) or 50 mg/kg/day of GAA (GAAH group). After 12 weeks of GAA treatment, histopathological results revealed that compared with that of the HFHC group, GAA significantly inhibited fat accumulation, steatosis, inflammation and fibrosis in the liver. GAA effectively reduced serum aspartate transaminase and alanine transaminase levels compared with the HFHC model. Furthermore, the endoplasmic reticulum (ER) stress‑responsive proteins, including glucose‑regulated protein 78, phosphorylated (p)‑eukaryotic initiation factor‑2α and p‑JNK, were significantly suppressed by GAA, while ERp57, p‑MAPK and p‑AKT were significantly increased after GAA treatment. Taken together, it was concluded that GAA could resist HFHC diet‑induced NASH. In terms of its underlying mechanism, GAA could improve liver inflammation and fibrosis by inhibiting hepatic oxidative stress and the ER stress response induced by HFHC.
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April-2022
Volume 23 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhu J, Ding J, Li S and Jin J: Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice. Exp Ther Med 23: 308, 2022
APA
Zhu, J., Ding, J., Li, S., & Jin, J. (2022). Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice. Experimental and Therapeutic Medicine, 23, 308. https://doi.org/10.3892/etm.2022.11237
MLA
Zhu, J., Ding, J., Li, S., Jin, J."Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice". Experimental and Therapeutic Medicine 23.4 (2022): 308.
Chicago
Zhu, J., Ding, J., Li, S., Jin, J."Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice". Experimental and Therapeutic Medicine 23, no. 4 (2022): 308. https://doi.org/10.3892/etm.2022.11237