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Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice

  • Authors:
    • Jing Zhu
    • Jiexia Ding
    • Siying Li
    • Jie Jin
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, The Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 308
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    Published online on: February 24, 2022
       https://doi.org/10.3892/etm.2022.11237
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Abstract

Non‑alcoholic steatohepatitis (NASH) is becoming a huge global health problem. Previous studies have revealed that ganoderic acids have hepatoprotective and hypocholesterolemic effects. In the present study, to evaluate the anti‑NASH activity of ganoderic acid A (GAA), male 6‑week‑old C57BL/6J mice were divided into the following four groups, which were administered different diets: Normal diet (ND group), high‑fat high‑cholesterol diet (HFHC group), HFHC diet supplemented with 25 mg/kg/day (GAAL group) or 50 mg/kg/day of GAA (GAAH group). After 12 weeks of GAA treatment, histopathological results revealed that compared with that of the HFHC group, GAA significantly inhibited fat accumulation, steatosis, inflammation and fibrosis in the liver. GAA effectively reduced serum aspartate transaminase and alanine transaminase levels compared with the HFHC model. Furthermore, the endoplasmic reticulum (ER) stress‑responsive proteins, including glucose‑regulated protein 78, phosphorylated (p)‑eukaryotic initiation factor‑2α and p‑JNK, were significantly suppressed by GAA, while ERp57, p‑MAPK and p‑AKT were significantly increased after GAA treatment. Taken together, it was concluded that GAA could resist HFHC diet‑induced NASH. In terms of its underlying mechanism, GAA could improve liver inflammation and fibrosis by inhibiting hepatic oxidative stress and the ER stress response induced by HFHC.
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1 

Kitade H, Chen G, Ni Y and Ota T: Nonalcoholic fatty liver disease and insulin resistance: New insights and potential new treatments. Nutrients. 9(387)2017.PubMed/NCBI View Article : Google Scholar

2 

Milic S, Lulic D and Stimac D: Non-alcoholic fatty liver disease and obesity: Biochemical, metabolic and clinical presentations. World J Gastroenterol. 20:9330–9337. 2014.PubMed/NCBI View Article : Google Scholar

3 

Sheka AC, Adeyi O, Thompson J, Hameed B, Crawford PA and Ikramuddin S: Nonalcoholic steatohepatitis: A review. JAMA. 323:1175–1183. 2020.PubMed/NCBI View Article : Google Scholar

4 

Anstee QM, Reeves HL, Kotsiliti E, Govaere O and Heikenwalder M: From NASH to HCC: Current concepts and future challenges. Nat Rev Gastroenterol Hepatol. 16:411–428. 2019.PubMed/NCBI View Article : Google Scholar

5 

Younossi Z, Anstee QM, Marietti M, Hardy T, Henry L, Eslam M, George J and Bugianesi E: Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol. 15:11–20. 2018.PubMed/NCBI View Article : Google Scholar

6 

Bonora E and Targher G: Increased risk of cardiovascular disease and chronic kidney disease in NAFLD. Nat Rev Gastroenterol Hepatol. 9:372–381. 2012.PubMed/NCBI View Article : Google Scholar

7 

Ferguson D and Finck BN: Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus. Nat Rev Endocrinol. 17:484–495. 2021.PubMed/NCBI View Article : Google Scholar

8 

Buzzetti E, Pinzani M and Tsochatzis EA: The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 65:1038–1048. 2016.PubMed/NCBI View Article : Google Scholar

9 

Horton JD, Goldstein JL and Brown MS: SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 109:1125–1131. 2002.PubMed/NCBI View Article : Google Scholar

10 

Han J and Kaufman RJ: The role of ER stress in lipid metabolism and lipotoxicity. J Lipid Res. 57:1329–1338. 2016.PubMed/NCBI View Article : Google Scholar

11 

Yan J and Horng T: Lipid metabolism in regulation of macrophage functions. Trends Cell Biol. 30:979–989. 2020.PubMed/NCBI View Article : Google Scholar

12 

Wachtel-Galor S, Yuen J, Buswell JA and Benzie IFF: Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom. In: Herbal Medicine: Biomolecular and Clinical Aspects. Benzie IFF and Wachtel-Galor S (eds). 2nd edition. CRC Press/Taylor & Francis, Boca Raton, FL, 2011.

13 

Paterson RR: Ganoderma-a therapeutic fungal biofactory. Phytochemistry. 67:1985–2001. 2006.PubMed/NCBI View Article : Google Scholar

14 

Sliva D: Cellular and physiological effects of Ganoderma lucidum (Reishi). Mini Rev Med Chem. 4:873–879. 2004.PubMed/NCBI View Article : Google Scholar

15 

Tong CC, Choong YK, Mohamed S, Mustapha NM and Umar NA: Nutrition & Food Science. Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet. Nutrition Food Sci. 38:229–238. 2008.

16 

Wasser SP: Reishi or ling zhi (Ganoderma lucidum). Encyclopedia Dietary Suppl. 1:603–622. 2005.

17 

Kabir Y, Kimura S and Tamura T: Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol. 34:433–438. 1988.PubMed/NCBI View Article : Google Scholar

18 

Li C, Li Y and Sun HH: New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum. Nat Prod Res. 20:985–991. 2006.PubMed/NCBI View Article : Google Scholar

19 

Xu JW, Zhao W and Zhong JJ: Biotechnological production and application of ganoderic acids. Appl Microbiol Biotechnol. 87:457–466. 2010.PubMed/NCBI View Article : Google Scholar

20 

Zhu J, Jin J, Ding J, Li S, Cen P, Wang K, Wang H and Xia J: Ganoderic Acid A improves high fat diet-induced obesity, lipid accumulation and insulin sensitivity through regulating SREBP pathway. Chem Biol Interact. 290:77–87. 2018.PubMed/NCBI View Article : Google Scholar

21 

Lang S, Demir M, Martin A, Jiang L, Zhang X, Duan Y, Gao B, Wisplinghoff H, Kasper P, Roderburg C, et al: Intestinal virome signature associated with severity of nonalcoholic fatty liver disease. Gastroenterology. 159:1839–1852. 2020.PubMed/NCBI View Article : Google Scholar

22 

Sun R, Liang H, Guo H, Wang Z and Deng Q: PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis. Mol Med Rep. 23(152)2021.PubMed/NCBI View Article : Google Scholar

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

24 

Ucar F, Sezer S, Erdogan S, Akyol S, Armutcu F and Akyol OJ: The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis. Redox Rep. 18:127–133. 2013.PubMed/NCBI View Article : Google Scholar

25 

Pan K, Jiang Q, Liu G, Miao X and Zhong D: Optimization extraction of Ganoderma lucidum polysaccharides and its immunity and antioxidant activities. Int J Biol Macromol. 55:301–306. 2013.PubMed/NCBI View Article : Google Scholar

26 

Liang C, Tian D, Liu Y, Li H, Zhu J, Li M, Xin M and Xia J: Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. Eur J Med Chem. 174:130–141. 2019.PubMed/NCBI View Article : Google Scholar

27 

Boh B, Berovic M, Zhang J and Zhi-Bin L: Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev. 13:265–301. 2007.PubMed/NCBI View Article : Google Scholar

28 

Liu F, Shi K, Dong J, Jin Z, Wu Y, Cai Y, Lin T, Cai Q, Liu L and Zhang Y: Ganoderic acid A attenuates high-fat-diet-induced liver injury in rats by regulating the lipid oxidation and liver inflammation. Arch Pharm Res. 43:744–754. 2020.PubMed/NCBI View Article : Google Scholar

29 

Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP and Wang YT: Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 83:408–414. 2012.PubMed/NCBI View Article : Google Scholar

30 

Lixin X, Lijun Y and Songping H: Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in mice. J Biochem Mol Toxicol. 33(e22271)2019.PubMed/NCBI View Article : Google Scholar

31 

Bessone F, Razori MV and Roma MG: Molecular pathways of nonalcoholic fatty liver disease development and progression. Cell Mol Life Sci. 76:99–128. 2019.PubMed/NCBI View Article : Google Scholar

32 

Bala S, Ganz M, Babuta M, Zhuang Y, Csak T, Calenda CD and Szabo G: Steatosis, inflammasome upregulation, and fibrosis are attenuated in miR-155 deficient mice in a high fat-cholesterol-sugar diet-induced model of NASH. Lab Invest. 101:1540–1549. 2021.PubMed/NCBI View Article : Google Scholar

33 

Ma JQ, Zhang YJ and Tian ZK: Anti-oxidant, anti-inflammatory and anti-fibrosis effects of ganoderic acid A on carbon tetrachloride induced nephrotoxicity by regulating the Trx/TrxR and JAK/ROCK pathway. Chem Biol Interact. 344(109529)2021.PubMed/NCBI View Article : Google Scholar

34 

Ganz M and Szabo G: Immune and inflammatory pathways in NASH. Hepatol Int. 7 (Suppl 2):S771–S781. 2013.PubMed/NCBI View Article : Google Scholar

35 

Heebøll S, Thomsen KL, Clouston A, Sundelin EI, Radko Y, Christensen LP, Ramezani-Moghadam M, Kreutzfeldt M, Pedersen SB, Jessen N, et al: Effect of resveratrol on experimental non-alcoholic steatohepatitis. Pharmacol Res. 95-96:34–41. 2015.PubMed/NCBI View Article : Google Scholar

36 

Ji G, Wang Y, Deng Y, Li X and Jiang Z: Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy. Lipids Health Dis. 14(134)2015.PubMed/NCBI View Article : Google Scholar

37 

Kessoku T, Imajo K, Honda Y, Kato T, Ogawa Y, Tomeno W, Kato S, Mawatari H, Fujita K, Yoneda M, et al: Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis. Sci Rep. 6(22251)2016.PubMed/NCBI View Article : Google Scholar

38 

Trautwein C, Friedman SL, Schuppan D and Pinzani M: Hepatic fibrosis: Concept to treatment. J Hepatol. 62 (Suppl 1):S15–S24. 2015.PubMed/NCBI View Article : Google Scholar

39 

Arroyave-Ospina JC, Wu Z, Geng Y and Moshage H: Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: Implications for prevention and therapy. Antioxidants (Basel). 10(174)2021.PubMed/NCBI View Article : Google Scholar

40 

Chen Z, Tian R, She Z, Cai J and Li H: Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. Free Radic Biol Med. 152:116–141. 2020.PubMed/NCBI View Article : Google Scholar

41 

Darling NJ and Cook SJ: The role of MAPK signalling pathways in the response to endoplasmic reticulum stress. Biochim Biophys Acta. 1843:2150–2163. 2014.PubMed/NCBI View Article : Google Scholar

42 

Parakh S, Jagaraj CJ, Vidal M, Ragagnin AMG, Perri ER, Konopka A, Toth RP, Galper J, Blair IP, Thomas CJ, et al: ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis. Hum Mol Genet. 27:1311–1331. 2018.PubMed/NCBI View Article : Google Scholar

43 

Koruk M, Taysi S, Savas MC, Yilmaz O, Akcay F and Karakok M: Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis. Ann Clin Lab Sci. 34:57–62. 2004.PubMed/NCBI

44 

Sutti S, Jindal A, Locatelli I, Vacchiano M, Gigliotti L, Bozzola C and Albano E: Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. Hepatology. 59:886–897. 2014.PubMed/NCBI View Article : Google Scholar

45 

Gabbia D, Cannella L and De Martin S: The Role of Oxidative Stress in NAFLD-NASH-HCC Transition-Focus on NADPH Oxidases. Biomedicines. 9(687)2021.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhu J, Ding J, Li S and Jin J: Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice. Exp Ther Med 23: 308, 2022.
APA
Zhu, J., Ding, J., Li, S., & Jin, J. (2022). Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice. Experimental and Therapeutic Medicine, 23, 308. https://doi.org/10.3892/etm.2022.11237
MLA
Zhu, J., Ding, J., Li, S., Jin, J."Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice". Experimental and Therapeutic Medicine 23.4 (2022): 308.
Chicago
Zhu, J., Ding, J., Li, S., Jin, J."Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice". Experimental and Therapeutic Medicine 23, no. 4 (2022): 308. https://doi.org/10.3892/etm.2022.11237
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu J, Ding J, Li S and Jin J: Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice. Exp Ther Med 23: 308, 2022.
APA
Zhu, J., Ding, J., Li, S., & Jin, J. (2022). Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice. Experimental and Therapeutic Medicine, 23, 308. https://doi.org/10.3892/etm.2022.11237
MLA
Zhu, J., Ding, J., Li, S., Jin, J."Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice". Experimental and Therapeutic Medicine 23.4 (2022): 308.
Chicago
Zhu, J., Ding, J., Li, S., Jin, J."Ganoderic acid A ameliorates non‑alcoholic streatohepatitis (NASH) induced by high‑fat high‑cholesterol diet in mice". Experimental and Therapeutic Medicine 23, no. 4 (2022): 308. https://doi.org/10.3892/etm.2022.11237
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