Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
April-2022 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2022 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling

  • Authors:
    • Jianwei Cao
    • Meiling Liu
    • Shufang Feng
    • Yingying Li
    • Kaijun Zheng
  • View Affiliations / Copyright

    Affiliations: Pediatrics Department, Zhongshan People's Hospital, Zhongshan, Guangdong 528403, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 313
    |
    Published online on: March 1, 2022
       https://doi.org/10.3892/etm.2022.11242
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glaucocalyxin A (GLA), an ent‑kauranoid diterpene derived from Rabdosia japonica var. glaucocalyx, possesses antibacterial, anti‑oxidative and anti‑neuroinflammatory properties. The present study aimed to investigate the potential mechanisms underlying GLA in the pathogenesis of pneumonia. Human pulmonary microvascular endothelial cells (hPMVECs) treated with lipopolysaccharide (LPS) were treated with GLA, followed by the detection of cell viability, inflammation, apoptosis and cell permeability. Furthermore, the protein expression levels of apoptosis‑ and permeability‑associated proteins were determined using western blot analysis. Following treatment with a signal transducer and activator of transcription 3 (STAT3) activator, the protein expression levels of STAT3 and endoplasmic reticulum stress‑associated proteins were determined, to confirm whether STAT3 signaling was mediated by GLA. Lastly, the mRNA expression level of inflammatory cytokines, apoptosis and permeability injury were also determined following treatment with a STAT3 activator. The results revealed that GLA ameliorated inflammation, apoptosis and permeability injury in LPS‑induced hPMVECs. Following treatment with a STAT3 activator, the therapeutic effects of GLA on LPS‑induced hPMVECs were abrogated. In conclusion, GLA alleviated LPS‑induced inflammation, apoptosis and permeability injury in hPMVECs by inhibiting STAT3 signaling, which highlighted the potential therapeutic value of GLA in the treatment of pneumonia.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Li W, An X, Fu M and Li C: Emergency treatment and nursing of children with severe pneumonia complicated by heart failure and respiratory failure: 10 Case reports. Exp Ther Med. 12:2145–2149. 2016.PubMed/NCBI View Article : Google Scholar

2 

Korppi M: Diagnosis and treatment of community-acquired pneumonia in children. Acta Paediatr. 101:702–704. 2012.PubMed/NCBI View Article : Google Scholar

3 

Simonetti AF, Viasus D, Garcia-Vidal C and Carratalà J: Management of community-acquired pneumonia in older adults. Ther Adv Infect Dis. 2:3–16. 2014.PubMed/NCBI View Article : Google Scholar

4 

Mattila JT, Fine MJ, Limper AH, Murray PR, Chen BB and Lin PL: Pneumonia. Treatment and diagnosis. Ann Am Thorac Soc. 11 (Suppl 4):S189–S192. 2014.PubMed/NCBI View Article : Google Scholar

5 

Dreyfuss D and Ricard JD: Acute lung injury and bacterial infection. Clin Chest Med. 26:105–112. 2005.PubMed/NCBI View Article : Google Scholar

6 

Zhang J, Mao F, Zhao G, Wang H, Yan X and Zhang Q: Long non-coding RNA SNHG16 promotes lipopolysaccharides-induced acute pneumonia in A549 cells via targeting miR-370-3p/IGF2 axis. Int Immunopharmacol. 78(106065)2020.PubMed/NCBI View Article : Google Scholar

7 

Zeng M, Sang W, Chen S, Chen R, Zhang H, Xue F, Li Z, Liu Y, Gong Y, Zhang H and Kong X: 4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models. Toxicol Lett. 271:26–37. 2017.PubMed/NCBI View Article : Google Scholar

8 

Zhang Y, Zhu Y, Gao G and Zhou Z: Knockdown XIST alleviates LPS-induced WI-38 cell apoptosis and inflammation injury via targeting miR-370-3p/TLR4 in acute pneumonia. Cell Biochem Funct. 37:348–358. 2019.PubMed/NCBI View Article : Google Scholar

9 

Zhou Z, Zhu Y, Gao G and Zhang Y: Long noncoding RNA SNHG16 targets miR-146a-5p/CCL5 to regulate LPS-induced WI-38 cell apoptosis and inflammation in acute pneumonia. Life Sci. 228:189–197. 2019.PubMed/NCBI View Article : Google Scholar

10 

Zang L, Song Y, Yu F and Liu X: Emodin relieved lipopolysaccharide-evoked inflammatory damage in WI-38 cells by up-regulating taurine up-regulated gene 1. Biofactors. 46:860–868. 2020.PubMed/NCBI View Article : Google Scholar

11 

Dong Z, Gao Q and Guo H: Glaucocalyxin A attenuates the activation of hepatic stellate cells through the TGF-β1/smad signaling pathway. DNA Cell Biol. 37:227–232. 2018.PubMed/NCBI View Article : Google Scholar

12 

Xiang Z, Wu X, Liu X and Jin Y: Glaucocalyxin A: A review. Nat Prod Res. 28:2221–2236. 2014.PubMed/NCBI View Article : Google Scholar

13 

Hou X, Xu G, Wang Z, Zhan X, Li H, Li R, Shi W, Wang C, Chen Y, Ai Y, et al: Glaucocalyxin A alleviates LPS-mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation. Int Immunopharmacol. 81(106271)2020.PubMed/NCBI View Article : Google Scholar

14 

Liu X, Xu D, Wang Y, Chen T, Wang Q, Zhang J, You T and Zhu L: Glaucocalyxin A ameliorates myocardial ischemia-reperfusion injury in mice by suppression of microvascular thrombosis. Med Sci Monit. 22:3595–3604. 2016.PubMed/NCBI View Article : Google Scholar

15 

Wang M, Zhang T, Li L, Xie Q, Wang Y, Li Y and Chen Z: Protective effects of HY1702 on lipopolysaccharide-induced mild acute respiratory distress syndrome in mice. Eur J Pharmacol. 887(173563)2020.PubMed/NCBI View Article : Google Scholar

16 

Yang F, Cao Y, Zhang J, You T and Zhu L: Glaucocalyxin A improves survival in bleomycin-induced pulmonary fibrosis in mice. Biochem Biophys Res Commun. 482:147–153. 2017.PubMed/NCBI View Article : Google Scholar

17 

Peng Z, Zhang R, Pan L, Pei H, Niu Z, Wang H, Lv J and Dang X: Glaucocalyxin A PRotects H9c2 cells against hypoxia/reoxygenation-induced injury through the activation of Akt/Nrf2/HO-1 pathway. Cell Transplant. 29(963689720967672)2020.PubMed/NCBI View Article : Google Scholar

18 

Zhu S, Zhang J and Lv Y: Glaucocalyxin A inhibits hydrogen peroxide-induced oxidative stress and inflammatory response in coronary artery smooth muscle cells. Clin Exp Pharmacol Physiol. 47:765–770. 2020.PubMed/NCBI View Article : Google Scholar

19 

Mao M, Zhang T, Wang Z, Wang H, Xu J, Yin F, Wang G, Sun M, Wang Z, Hua Y and Cai Z: Glaucocalyxin A-induced oxidative stress inhibits the activation of STAT3 signaling pathway and suppresses osteosarcoma progression in vitro and in vivo. Biochim Biophys Acta Mol Basis Dis. 1865:1214–1225. 2019.PubMed/NCBI View Article : Google Scholar

20 

Zhao J, Yu H, Liu Y, Gibson SA, Yan Z, Xu X, Gaggar A, Li PK, Li C, Wei S, et al: Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol. 311:L868–L880. 2016.PubMed/NCBI View Article : Google Scholar

21 

Wang L, Astone M, Alam SK, Zhu Z, Pei W, Frank DA, Burgess SM and Hoeppner LH: Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability. bioRxiv: doi: 10.1101/2020.10.27.358374.

22 

Meng J, Liu K, Shao Y, Feng X, Ji Z, Chang B, Wang Y, Xu L and Yang G: ID1 confers cancer cell chemoresistance through STAT3/ATF6-mediated induction of autophagy. Cell Death Dis. 11(137)2020.PubMed/NCBI View Article : Google Scholar

23 

Jiang CQ, Ma LL, Lv ZD, Feng F, Chen Z and Liu ZD: Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells. J Nat Med. 74:533–544. 2020.PubMed/NCBI View Article : Google Scholar

24 

Qs L, K C, Ap L, F X, Qw H, Z L, Qh Y, YI W, Zz Z and J Z: Roles of M3 receptor in the effect of penehyclidine hydrochloride upregulated beta-arrestin-1 expression in LPS-stimulated HPMVEC. J Recept Signal. 39:39–44. 2019.PubMed/NCBI View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

26 

Vallverdú J, Martínez García de la Torre RA, Mannaerts I, Verhulst S, Smout A, Coll M, Ariño S, Rubio-Tomás T, Aguilar-Bravo B, Martínez-Sánchez C, et al: Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells. Nat Protoc. 16:2542–2563. 2021.PubMed/NCBI View Article : Google Scholar

27 

Zhou Y, Li P, Goodwin AJ, Cook JA, Halushka PV, Chang E, Zingarelli B and Fan H: Exosomes from endothelial progenitor cells improve outcomes of the lipopolysaccharide-induced acute lung injury. Crit Care. 23(44)2019.PubMed/NCBI View Article : Google Scholar

28 

Fang YY and Zhang JH: MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia. Int J Neurosci. 131:15–24. 2021.PubMed/NCBI View Article : Google Scholar

29 

Mizgerd JP: Inflammation and pneumonia: Why are some more susceptible than others? Clin Chest Med. 39:669–676. 2018.PubMed/NCBI View Article : Google Scholar

30 

Jae SY, Heffernan KS, Kurl S, Kunutsor SK, Kim CH, Johnson BD, Franklin BA and Laukkanen JA: Cardiorespiratory fitness, inflammation, and the incident risk of pneumonia. J Cardiopulm Rehabil Prev. 41:199–201. 2021.PubMed/NCBI View Article : Google Scholar

31 

Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL and Riches DW: Tumor necrosis factor-α accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol. 50:825–837. 2014.PubMed/NCBI View Article : Google Scholar

32 

Jiang Z, Shen J, Ding J, Yuan Y, Gao L, Yang Z and Zhao X: USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4/NF-κB/ROS signaling. Toxicol In Vitro. 75(105181)2021.PubMed/NCBI View Article : Google Scholar

33 

Zhang D, Zhou J, Ye LC, Li J, Wu Z, Li Y and Li C: Autophagy maintains the integrity of endothelial barrier in LPS-induced lung injury. J Cell Physiol. 233:688–698. 2018.PubMed/NCBI View Article : Google Scholar

34 

Wang T, Yegambaram M, Gross C, Sun X, Lu Q, Wang H, Wu X, Kangath A, Tang H, Aggarwal S and Black SM: RAC1 nitration at Y32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury. Redox Biol. 38(101794)2021.PubMed/NCBI View Article : Google Scholar

35 

Lee H, Jeong AJ and Ye SK: Highlighted STAT3 as a potential drug target for cancer therapy. BMB Rep. 52:415–423. 2019.PubMed/NCBI View Article : Google Scholar

36 

Jones MR, Quinton LJ, Simms BT, Lupa MM, Kogan MS and Mizgerd JP: Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J Infect Dis. 193:360–369. 2006.PubMed/NCBI View Article : Google Scholar

37 

Quinton LJ, Jones MR, Robson BE, Simms BT, Whitsett JA and Mizgerd JP: Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 38:699–706. 2008.PubMed/NCBI View Article : Google Scholar

38 

Teng RJ, Jing X, Michalkiewicz T, Afolayan AJ, Wu TJ and Konduri GG: Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 312:L586–L598. 2017.PubMed/NCBI View Article : Google Scholar

39 

Severgnini M, Takahashi S, Rozo LM, Homer RJ, Kuhn C, Jhung JW, Perides G, Steer M, Hassoun PM, Fanburg BL, et al: Activation of the STAT pathway in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 286:L1282–L1292. 2004.PubMed/NCBI View Article : Google Scholar

40 

Meng SS, Guo FM, Zhang XW, Chang W, Peng F, Qiu HB and Yang Y: mTOR/STAT-3 pathway mediates mesenchymal stem cell-secreted hepatocyte growth factor protective effects against lipopolysaccharide-induced vascular endothelial barrier dysfunction and apoptosis. J Cell Biochem. 120:3637–3650. 2019.PubMed/NCBI View Article : Google Scholar

41 

Zhang L, Lu P, Guo X, Liu T, Luo X and Zhu YT: Inhibition of JAK2/STAT3 signaling pathway protects mice from the DDP-induced acute kidney injury in lung cancer. Inflamm Res. 68:751–760. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cao J, Liu M, Feng S, Li Y and Zheng K: Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling. Exp Ther Med 23: 313, 2022.
APA
Cao, J., Liu, M., Feng, S., Li, Y., & Zheng, K. (2022). Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling. Experimental and Therapeutic Medicine, 23, 313. https://doi.org/10.3892/etm.2022.11242
MLA
Cao, J., Liu, M., Feng, S., Li, Y., Zheng, K."Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling". Experimental and Therapeutic Medicine 23.4 (2022): 313.
Chicago
Cao, J., Liu, M., Feng, S., Li, Y., Zheng, K."Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling". Experimental and Therapeutic Medicine 23, no. 4 (2022): 313. https://doi.org/10.3892/etm.2022.11242
Copy and paste a formatted citation
x
Spandidos Publications style
Cao J, Liu M, Feng S, Li Y and Zheng K: Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling. Exp Ther Med 23: 313, 2022.
APA
Cao, J., Liu, M., Feng, S., Li, Y., & Zheng, K. (2022). Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling. Experimental and Therapeutic Medicine, 23, 313. https://doi.org/10.3892/etm.2022.11242
MLA
Cao, J., Liu, M., Feng, S., Li, Y., Zheng, K."Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling". Experimental and Therapeutic Medicine 23.4 (2022): 313.
Chicago
Cao, J., Liu, M., Feng, S., Li, Y., Zheng, K."Glaucocalyxin A alleviates lipopolysaccharide‑induced inflammation and apoptosis in pulmonary microvascular endothelial cells and permeability injury by inhibiting STAT3 signaling". Experimental and Therapeutic Medicine 23, no. 4 (2022): 313. https://doi.org/10.3892/etm.2022.11242
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team