Influence of vitamin D receptor polymorphism rs2228570 on pathological scarring

Ilieș,Roxana Flavia; Aioanei,Casian Simon; Halmagyi,Salomea-Ruth; Cătană,Andreea; Lukacs,Istvan; Tokes,Reka-Eniko; Rotar,Ioana Cristina; Pop,Ioan Victor

doi:10.3892/etm.2022.11264

May-2022 Volume 23 Issue 5

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May-2022 Volume 23 Issue 5

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Article

Influence of vitamin D receptor polymorphism rs2228570 on pathological scarring

Authors:
- Roxana Flavia Ilieș
- Casian Simon Aioanei
- Salomea-Ruth Halmagyi
- Andreea Cătană
- Istvan Lukacs
- Reka-Eniko Tokes
- Ioana Cristina Rotar
- Ioan Victor Pop
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Affiliations: Department of Medical Genetics, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, 1st Department of Obstetrics and Gynecology, ‘Iuliu Hațieganu’ University of Medicine and Pharmacy, 400006 Cluj‑Napoca, Romania
Article Number: 345
|
Published online on: March 22, 2022

https://doi.org/10.3892/etm.2022.11264
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Abstract

The physiological process of scarring is a common denominator of interest in a plethora of medical specialties. The molecular basis whereby this process results in pathological scarring for some individuals is poorly understood at present, with clues pointing towards individual predisposition for pathological scarring. Vitamin D and its subsequent pathway plays a key role in skin metabolism and homeostasis, with alterations in the level of vitamin D receptor (VDR) seen within pathological scars. The present study investigated the role of the rs2228570 polymorphism of VDR with regards to scar formation and evolution in a group of 71 female patients recovering from Caesarian section. Blood samples were taken at the time of surgery, and the follow‑up was collected remotely at 3 and 6 months after surgery. The rs2228570 polymorphism was investigated using an RFLP‑PCR protocol. The results demonstrated that the CC genotype, in combination with the Patient Observer Scar Assessment Scale (POSAS) and SCAR scores are associated with pathological scarring, with more studies being necessary to draw a firm conclusion.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Influence of vitamin D receptor polymorphism rs2228570 on pathological scarring

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